β-Blockers Flashcards

1
Q

Action of Bisoprolol

A

β1

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2
Q

Action of Atenolol

A

β1

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3
Q

Action of Metoprolol

A

β1

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4
Q

Action of Labetalol

A

β + α

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5
Q

Action of Carvedilol

A

β + α1

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6
Q

Action of Propranolol

A

β (+ weak 5-HT antagonist)

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7
Q

Action of Sotalol

A

β (+ K+ channel blocker)

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8
Q

PPB of Carvedilol (%)

A

98

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9
Q

PPB of Propranolol (%)

A

90

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10
Q

PPB of Labetalol (%)

A

50

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11
Q

PPB of Bisoprolol (%)

A

30

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12
Q

PPB of Atenolol (%)

A

16%

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13
Q

PPB of Metoprolol (%)

A

12%

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14
Q

PPB of Sotalol (%)

A

0%

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15
Q

Metabolism of Bisoprolol

A

50% Liver

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16
Q

Metabolism of Carvedilol

A

Liver

17
Q

Metabolism of Propranolol

A

Liver

18
Q

Metabolism of Metoprolol

A

Liver

19
Q

Metabolism of Sotalol

A

Renal excretion

20
Q

Metabolism of Atenolol

A

Renal excretion

21
Q

Metabolism of Labetalol

A

Liver

22
Q

PO Bioavailability of Bisoprolol

A

90%

23
Q

PO Bioavailability of Sotalol

A

100%

24
Q

PO Bioavailability of Metoprolol

A

50%

25
Q

PO Bioavailability of Propranolol

A

25%

26
Q

PO Bioavailability of Labetalol

A

25%

27
Q

PO Bioavailability of Atenolol

A

50%

28
Q

PO Bioavailability of Carvedilol

A

35%

29
Q

T1/2 of Bisoprolol

A

12h

30
Q

T1/2 of Sotalol

A

12h

31
Q

T1/2 of Carvedilol

A

10h

32
Q

T1/2 of Atenolol

A

7h

33
Q

T1/2 of Metoprolol

A

7h

34
Q

T1/2 of Labetalol

A

4h

35
Q

T1/2 of Propranolol

A

5h