Opioid analgesics

Question 1

Strong opioid agonists

Answer 1

morphine
methadone (dolopine)

Question 2

Moderate opioid agonists

Answer 2

codeine

Question 3

mixed opioid agonist-antagonist

Answer 3

pentazocine (Talwin)

buprenophine (buprenex)

Question 4

opioid antagonists

Answer 4

naloxone (narcan)-works faster

naltrexone (revia) - long lasting

Question 5

morphine duration of action

Answer 5

4-6 hours

Question 6

morphine active metabolite

Answer 6

morphine-6-glucuronide

Question 7

Heroin

Answer 7

(acetylmorphine)- more lipid soluble and fast acting

Question 8

methadone (dolophine)

Answer 8

15-20 hr duration of action

good for detox and controlled withdrawal from heroin or morphine

Question 9

meperidien (demerol)

Answer 9

less potent than morphine, shorter duration of action (2-4 hr) good for OB or post-op analgesia

Question 10

fentanyl (sublimaze)

Answer 10

rapid onset, 80x potency of morphine, short duration of action (15-30 min)

Question 11

codeine

Answer 11

metabolized to morphine for analgesia
used with aspirin or acetaminophen.
cough syrup

Question 12

tramadol (ralivia)

Answer 12

synthetic analog of codeine, moderate u- receptor agonist, treatment of moderate pain. alternative to NSAIDs

Question 13

Pentazocine (talwin)

Answer 13

K-receptor agonist with weak u-receptor antagonist

Question 14

buprenorphine (burenex)

Answer 14

partial agonist at u receptor
antagonist at k-receptor
resistant to naloxone reversal
used to manage cocaine and heroin abuse

Question 15

naloxone

Answer 15

competitive antagonist (t1/2 is 1-2 hrs)

Question 16

naltrexone (revia)

Answer 16

competitive agonist (t1/2 is 10 hrs)