adrenal and thyroid diseases

Question 1

zona glomerulosa steroids

Answer 1

Mineralocorticoids

Question 2

zonae fasciculata/reticularis steroids

Answer 2

glucocorticoids

adrenal androgens

Question 3

glucocorticoids

Answer 3

adrenal cortical steroid
carbohydrate metabolism
major type: hydrocortisone/cortisol

Question 4

Mineralocorticoids

Answer 4

adrenal cortical steroid
Electrolyte-water homeostasis
major type: aldosterone

Question 5

Endogenous corticosteroid

Answer 5

aldosterone and hydrocortisone/ cortisol

Question 6

synthetic corticosteroid

Answer 6

prednisone, prednisolone, dexamethasone, betamethasone, fludrocortisone

Question 7

mech of action

Answer 7

transcriptional regulation- changes of protein level

Question 8

Glucocorticoid receptor

Answer 8

widespread expression and broad effects

low affinity for aldosterone

Question 9

mineralocorticoid receptor

Answer 9

restricted expression: abundant in renal distal tubules and collecting ducts
equal sensitivity to both cortisol and aldosterone

Question 10

Corticosteroid binding globulin (CBG)

Answer 10

binds >80% of circulating cortisol, 20% is available and loosely bound to albumin

adoosterone does not bind to CBG, short half life
dexamethasone doesnt bind to CBG, 100% active

Question 11

cortisol and cortisone

Answer 11

• short acting

- considerable salt-retaining activity

Question 12

Prednisone, prednisolone, mehtylprednisolone

Answer 12

intermediate acting

intermediate anti-inflammatory and salt retaining activity

Question 13

dexamethasone, betamethasone

Answer 13

long acting

maximal anti inflamamatory, minimal salt retaining