Ophthalmology Flashcards
Name the condition:
- small, irregular pupils
- Accommodation reflex present (ARP)
- Pupillary reflex absent (PRA) (no response to light)
Causes (2)
Argyll-Robertson pupil
Causes
- Syphillis
- Diabetes
- Dilated pupil
- Unilateral
- Slowly reactive to accommodation
- Minimal if at all response to light
- Once pupil constricted it remains small for an abnormally long time
Holmes-Adie pupil
Benign condition common in women
What is Holmes-Adie syndrome?
Association of Holmes-Adie pupil with absent ankle/knee reflexes
Glaucoma types (3) Caused by?
- Closed angle/ angle closure glaucoma
- Opened angle glaucoma
- Normal-tension
Caused by raised intraocular pressure secondary to impairment of aqueous flow
Closed angle/ angle closure glaucoma (8)
Insidious vs sudden Pain or no pain Red or not red Sight Dilated or restricted Other features (2) Worse with restricted or dilated pupils
Raised IOP due to narrow angle between iris and cornea, passage for outflow of aq. humour is too narrow. Due to lens being pushed against iris.
Features
- Sudden onset eye/ head pain
- Hard, red eye
- Haloes
- Decreased visual acuity
- Semi-dilated non reacting pupil
- Worse with mydriaisis
- Systemic upset e.g N&V, AP
- Corneal oedema, dull/ hazy cornea
What does hypermetropia mean?
What does mydriasis mean?
What does myopia mean?
To be long sighted
Dilated pupils
Short/near sighted
Closed angle/ angle closure
Predisposing factors
- Hypermetropia
- Pupillary dilatation
- Lens growth associated with age
Closed angle/ angle closure
Mx
Emergency - refer to ophthalmologist
- Pilocarpine (increased outflow of the aqueous humour))
- BB (e.g. timolol, decreases aqueous humour production)
- alpha-2 agonist (e.g. apraclonidine, dual mechanism, decreasing aqueous humour production and increasing uveoscleral outflow)
- intravenous acetazolamide (reduces aqueous secretions)
Post acute attack
1. Laser peripheral iridotomy
Creates a tiny hole in the peripheral iris → aqueous humour flowing to the angle
Primary open angle glaucoma
RFs (6)
- HTN
- DM
- Steroids
- FH
- Black
- Myopia
Primary open angle glaucoma
Features (3)
- Insidious onset
- Peripheral visual field loss/ tunnel vision/ scotomas
- Optic disc cupping
Fundoscopy signs of primary open-angle glaucoma (5)
- Optic disc cupping
- Optic disc pallor
- Bayonetting of vessels
- Cup notching (usually inferior where vessels enter disc)
- Disc haemorrhages
Primary open angle glaucoma
Mx
First line
1. prostaglandin analogue (PGA) eyedrops
Second line
2. BB, carbonic anhydrase inhibitor, or sympathomimetic eye drops
If more advanced
3. surgery or laser treatment can be tried
What is transient monocular visual loss (TVML)
Name four causes:
Visual loss lasting less than 24 hours Causes 1. ischaemic/vascular (e.g. thrombosis, embolism, temporal arteritis etc). e.g. occlusion of central retinal vein/artery 2. vitreous haemorrhage 3. retinal detachment 4. retinal migraine
Dense shadow that starts peripherally progresses towards the central vision
A veil or curtain over the field of vision
Straight lines appear curved
Central visual loss
Retinal tear
Retinal detachment
features include afferent pupillary defect, ‘cherry red’ spot on a pale retina
Due to thromboembolism
Central retinal artery occlusion
severe retinal haemorrhages are usually seen on fundoscopy
causes: glaucoma, polycythaemia, hypertension
=
Central retinal vein occlusion
causes: diabetes, bleeding disorders, anticoagulants
features may include sudden visual loss, dark spots
=
Vitreous haemorrhage
Flashes of light (photopsia) - in the peripheral field of vision
Floaters, often on the temporal side of the central vision
=
Posterior vitreous detachment
Herpes zoster ophthalmicus
Mx
- PO antivirals for 7-10 to be started within 72 hours of rash - IV if immunocompromised or very severe
- Topical steroids in any inflammation of the eye
If eye involvement –> ophth review
Features of herpes zoster opthalmicus
- vesicular rash around the eye, which may or may not involve the actual eye itself
- Hutchinson’s sign
What is Hutchinson’s sign?
rash on the tip or side of the nose. Indicates nasociliary involvement and is a strong risk factor for ocular involvement
Seen in herpes zoster opthalmicus
RA ocular manifestations (5)
Iatrogenic ocular manifestations (2)
- keratoconjunctivitis sicca (most common)
- episcleritis (erythema)
- scleritis (erythema and pain)
- corneal ulceration
- keratitis
Iatrogenic
steroid-induced cataracts
chloroquine retinopathy
Scleritis
Features (4)
- red, watery eye
- classically painful (in comparison to episcleritis)
- photophobia
- gradual decrease in vision
How to differentiate between scleritis and episcleritis
Mx episcleritis
Sclertitis painful, episcleritis isn’t
phenylephrine drops can be used to differentiate between the two. If eye redness improves after phenylephrine –> episcleritis
Mx artificial tears
What is keratitis?
Common bacteria (2)
Inflammation of the cornea
Microbial keratitis is potentially sight threatening and should therefore be urgently evaluated and treated
- Staph A
- Pseudomonas aeruginosa is seen in contact lens wearers
Keratitis
Features (4)
- red eye: pain and erythema
- photophobia
- foreign body, gritty sensation
- hypopyon may be seen
Painful red eye in a contact lens wearer
Diagnostic test
Mx
Keratitis Slit lamp Mx 1. Topical quinolone 2. Cycloplegic for pain relief
Age Related Macular Degeneration (ARMD)
Features (5)
Speed of visual loss What type of sight is lost first? (2) Other features (2)
- Subacute visual loss
- Near field loss
- Deterioration at night
- Photopsia, (a perception of flickering or flashing lights),
- Crooked or wavy appearance to straight lines
ARMD
Ix including fundoscopy findings (5)
Fundoscopy findings in wet ARMD
- Amsler grid testing - distortion of line perception
- Fundoscopy: drusen + central scotoma
- slit-lamp microscopy + colour fundus photography
- fluorescein angiography (wet ARMD)
- ocular coherence tomography (wet ARMD)
Fundoscopy- wet ARMD well demarcated red patches may be seen which represent intra-retinal or sub-retinal fluid leakage or haemorrhage
ARMD types
Dry 90% of cases
Wet 10% of cases
- worse prognosis
What is the role of vascular endothelial growth factor (VEGF) in ARMD?
VEGF stimulates new vessel growth in wet ARMD which leads to oedema and more rapid loss of acuity.
ARMD
Mx
Dry
Wet
- Dry ARMD zinc with anti-oxidant vitamins A,C and E
2. Wet ARMD anti-VEGF agents, e.g ranibizumab, bevacizumab and pegaptanib - 4 weekly injection.
Define: Blepharitis Stye Chalazion Entropion Ectropion
blepharitis: inflammation of the eyelid margins typically leading to a red eye, grittiness and discomfort
stye: infection of the glands of the eyelids
chalazion = Meibomian cyst
entropion: in-turning of the eyelids
ectropion: out-turning of the eyelids
What is a chalazion?
Mx
Retention cyst of the Meibomian gland. It presents as a firm painless lump in the eyelid. Resolve spontaneously some require surgical drainage