Ophthalmology Flashcards
Difficulty in reading text and recognising faces, and problems with vision in dim light are typical features of which condition
Dry AMD
“Old people like to read the newpaper and thus they notice if they cant anymore (age related)”
Difficulty driving at night is a typical feature of which condition
Cataracts
Patients often complain of knocking over objects is a typical feature of which condition
Chronic open angle glaucoma
In chronic OAG the peripheral visual fields is affected first so patients often complain of knocking over objects.
Likely Dx
Painful ear, purulent discharge and keen swimmer
Otitis externa
Potential complication of otitis externa
Malignant otitis externa
Likely Dx
Otalgia (ear pain) worse at night
Otorrhoea (ear discharge)
Granulation tissue seen in the external auditory canal on otoscopy
+/- facial palsy
Malignant otitis externa
Likely Dx
Acute-onset otalgia +/- fever which often precedes an upper respiratory tract infection
Acute otitis media
What is the otoscopic features of an acute otitis media
Hyperaemic, bulging and featureless tympanic membrane
Acute mastoiditis is a complication of what condition
Acute otitis media
Likely Dx
Retro-auricular pain
Conductive hearing loss
Fever
On examination, the tympanic membrane is protruding forwards
Recent Hx of acute otitis media
Acute mastoiditis
What are the two most common organisms that causes otitis externa?
Pseudomonas spp
Staphylococcus aureus
What is the best treatment for blepharitis
Hot compress and mechanical removal of the debris +/- artificial tears if patients report dry eyes
Hot compresses to soft the eyelid margin
Removal of debris with cotton buds dipped in cooled boiled water
Dendritic ulcers seen under slit lamp with fluorescein applied is pathognomonic for which condition?
Herpes simplex keratitis
What causes Herpes Simplex Keratitis
Caused by reactivation of the herpes simplex virus type 1 (HSV1) which lies dormant in the trigeminal ganglion
How is Herpes Simplex Keratitis managed
Topical acyclovir
Likely Dx:
Eye pain out of proportion to the findings
Eye redness
Decreased visual acuity
Contact lens wearer
Acanthamoeba keratitis
In contact lens wearers, the causative organism in Acanthamoeba keratitis
Pseudomonas
A painful red eye with photophobia, foreign body sensation and blurring of vision is highly suspicious for what?
Keratitis (inflammation of the cornea)
Dendritic ulcer with a shingles rash in the ophthalmic dermatome is pathognomonic of which condition?
Herpes Zoster Ophthalmicus
Management of bacterial keratitis
Immediate ophthalmologist referral as it is an emergency
Management involves stopping the use of contact lenses, intensive topical (and sometimes oral) antibiotics – in severe infections, patients need to be admitted
Feature of mild non-proliferative diabetic retinopathy
Microaneurysms only on fundus
Features of moderate non-proliferative diabetic retinopathy
One of the following features:
Retinal haemorrhages
Hard exudates
Cotton wool spots
Venous changes (beading/looping)
Features of severe non-productive diabetic retinopathy
4-2-1 rule
4 quadrants with haemorrhage
OR
2 quadrants with venous beading
OR
1 quadrant with IRMA (intra-retinal microvascular abnormality - an abnormal new vessel between a venule and arteriole that is weak and prone to haemorrhage)
What are the features of proliferative diabetic retinopathy seen on fundoscopy
New vessels at the retina or optic disc
Exudates seen on fundoscopy is pathognomonic for what condition
Diabetic retinopathy
What are the two treatment options for proliferative retinopathy
Panretinal laser photocoagulation ( intentional scarring of peripheral retinal tissue)
AND/OR
Intravitreal VEGF inhibitors
If severe or vitreous haemorrhage: vitreoretinal surgery
Likely Dx:
Severe unilateral eye pain, redness and reduced vision.
Pain worsen on eye movement and at night
Photophobia
Background Hx of rheumatological conditions
Scleritis
What is the distinguishing feature between episcleritis and scleritis
Episcleritis:
No pain
No photophobia
No unilateral reduction in vision
Scleritis causes severe unilateral eye pain that is worse at what time?
At night
First line management for mild scleritis
Oral NSAIDs
First line management for severe or necrotising scleritis
Corticosteroids
Either daily oral prednisolone or pulsed IV methylprednisolone
Likely Dx:
PMH of diabetic retinopathy
Fundoscopy of the eye shows a red opacity lying in front of it
Vitreous haemorrhage
Proliferative diabetic retinopathy is one of the causes of vitreous haemorrhage as the new blood vessels are weak and prone to damage and haemorrhage, which then accumulates in the vitreous
Fundoscopy shows serrated area of grey retina.
Diagnosis?
Retinal detachment
Detached retina. It is possible to have a concomitant vitreous haemorrhage and retinal detachment and of course, the obscured fundal view because of the haemorrhage makes the detachment difficult to diagnose clinically. As a result, B-scan ultrasound is indicated to check the retina is not detached
16%
Define myopia
Short-sightedness
Define hyperopia
Far-sightedness
Curtain or shadow progressing to the centre of the visual field from the periphery is pathognomonic of what condition
Retinal detachment
What kind of the pupillary defect may be detected in retinal detachment
Relative afferent pupillary defect if the optic nerve is involved
Fundoscopy showing drusen (poorly defined, heterogenous, cloudy-yellow deposits) within the macula is pathognomonic of what condition
Dry Age-related macular degeneration (dry-ARMD)
Pilocarpine 4% eye drops function
Reduces the intraocular pressure
Useful in acute angle closure glaucoma to prevent further damage to the optic nerve and preserve vision.
Other drugs that can be used to reduce the IOP include: oral Acetazolamide, Timolol 0.25% eye drops and Brimonidine 0.1% eye drops
Likely Dx:
Severe eye pain
Blurred vision
Haloes around lights
Fixed-dilated pupil
Acute angle closure glaucoma
What is the definitive treatment for acute angle closure glaucoma
Laser peripheral iridotomy
Prednisolone (1%) eye drops is used to treat what eye condition
Acute anterior uveitis
What is the immediate management of acute angle closure glaucoma
Reducing the intraocular pressure most commonly with eye drops that can reduce the IOP e.g. Pilocarpine 4% eye drops, oral Acetazolamide, Timolol 0.25% eye drops and Brimonidine 0.1% eye drops
The intraocular pressure must be reduced as soon as possible to prevent further damage to the optic nerve and preserve vision.
Patients with acute angle closure glaucoma is started on a triad of medications.
What is that triad
Beta blockers eye drops e.g. Timolol (to reduce aqueous production)
Pilocarpine eye drops (to increase uveoscleral outflow)
IV acetazolamide (to reduce aqueous production)
Pale retina with a cherry red spot at the macula on ophthalmoscopy is a characteristic feature of what condition
Central retinal artery occlusion (CRAO)
Pale retina as it no longer receives blood from the retinal artery
Cherry red spot as the retina now receives blood from the choroidal circulation, which lies behind the macula. This relative hyperaemia of the macula compared to the rest of the retina gives CRAO the characteristic ‘cherry red spot’ appearance
Drusen at the macular on ophthalmoscopy is a characteristic feature of what condition
Dry age related macular degeneration (Age AMD)
Optic disc cupping on ophthalmoscopy is a characteristic feature of what condition
Chronic open angle glaucoma
Likely Dx:
Sudden, painless unilateral visual loss
‘Cherry red’ spot on a pale retina
Central retinal artery occlusion
Drusen in the macula on fundoscopy is a hallmark of what condition?
Dry age-related macular degeneration (ARMD)
DRusen = DRy
‘stormy sunset’ on fundoscopy is pathognomonic of what condition
Central retinal vein occlusion (CRVO)
Stormy sunset is caused by retinal hyperaemia & haemorrhages
flame haemorrhages are characteristics of what condition
Central retinal vein occlusion (CRVO)
What are the two complications of diabetic retinopathy that can develop if not managed
Vitreous haemorrhage
Retinal detachment
Toxoplasma retinitis is a parasite that is transmitted via the faecal-oral route from faeces from what animal
Cat
Chorioretinitis (a single, hazy white/yellow lesion) seen on fundoscopy with an adjacent area of hyper-pigmentation of the retina is characteristic of what condition
Toxoplasma retinitis
‘pizza pie fundus’ on fundoscopy is characteristic of what condition
Cytomegalovirus (CMV) retinitis
Typically presents in immunocompromised patients with a CD4 count < 50
What is the mainstay of management of wet AMD
Intravitreal injection with vascular endothelial growth factor inhibitors (anti-VEGF)
Vascular disease leads to oedema beneath the macula. To stop the oedema progressing, neovascularisation needs to be blocked through the use of anti-vascular endothelial growth factor injections. A laser cannot be used on the macula as it may damage the photoreceptors which are responsible for most of our functional vision
What is the the biggest risk factor for developing age related macular degeneration
Age
Drusen, macular thinning (geographic atrophy) is features of what kind of age related macular degeneration
Dry AMD
Neovascularisation, bleeding, leakage of fluid is features of what kind of age related macular degeneration
Wet AMD
What is an important lifestyle change for patients with age related macular degeneration
Smoking cessation
Red eye post-eye surgery should prompt the diagnosis of what?
Endophthalmitis (infection inside the patient’s eye)
Hypopyon, described in the stem as a ‘white fluid level’, which is a collection of pus in the anterior chamber is indicative of what?
Intraocular inflammation
How is endophthalmitis managed
It is treated with intravitreal vancomycin as the most common causative bugs are gram positive
How is endophthalmitis managed
Intravitreal vancomycin as the most common causative organisms are gram positive
Pts with Bells palsy are advised to tape their affected eye at night and apply artificial tears daily until the palsy has resolved.
What condition are these measures preventing?
Exposure keratopathy i.e. damage to the corneal epithelium which may become infected leading to sight-threatening keratitis
How are suspected orbital fractures are best assessed
Computed tomography (CT) orbits, brain, sinus
Blunt force trauma to the face with subsequent eye pain can be caused a fracture to what bone most commonly
Fracture of the ethmoid bone - the pressure from the force causes fracture of the orbital floor. The ethmoid bone forms the medial wall of the orbit, which is commonly fractured as it is very thin.
Another feature is enophthalmos (sunken in affected eye)
What is a common side effect of prostaglandin analogue eye drops e.g. latanoprost
Eyelash thickening/lengthening
Fundoscopic/slit-lamp features of chronic open angle glaucoma
Pale optic disc – indicates optic nerve atrophy
Optic disc cupping – a cup:disc ratio of >0.7 suggests cupping
What is the aim of management in chronic open angle glaucoma
The aim of management is to prevent progression of glaucoma and preserve visual fields and acuity.
This is done by reducing the intraocular pressure by either reducing aqueous production or increasing uveoscleral outflow.
What is the first line management option of chronic open angle glaucoma
Surgery with selective laser trabeculoplasty (SLT)
Latanoprost is an example of what kind of eye drop drug class
Prostaglandin analogues
Latanoprost eye drop is an example of prostaglandin analogues.
What effect does prostaglandin analogues have in the eye
Increases uveoscleral outflow
Timolol is an example of what kind of eye drop drug class
Beta blocker
Timolol eye drop is an example of a beta blocker eye drop.
What effect does beta blockers have in the eye
Reduces aqueous production
Beta BLOCKer = BLOCK the production
What two patient groups are Beta blocker eye drops contraindicated in
Asthma
Heart block
What is the second line management option for chronic open angle glaucoma
(used when selective laser trabeculoplasty (first line) is not possible and for patients who have chosen not to have SLT or who has progression of glaucoma despite first line treatment)
Medical management with eye drops to reduce the intraocular pressure
First line: Prostaglandin analogues e.g. Latanoprost
Second line: Topical beta blockers e.g. Timolol
Likely Dx:
Young patient
‘Tunnel vision’
Reduced visual acuity in dim light.
Retinitis pigmentosa
What features would be noticed in the cerebrospinal fluid (CSF) in multiple sclerosis
Oligoclonal bands - which are IgG clones produced in the CSF as a result of the T-cell mediated inflammation
There are 4 diagnoses requiring urgent referral that must be ruled out for any patient presenting with ocular pain.
What are these four conditions?
Acute angle closure glaucoma
Anterior uveitis
Scleritis
Corneal ulcer