one-eyed sheep Flashcards
1
Q
what is gorlins syndrom
A
constant growth of basal cell carcinomas
2
Q
why did sheep have 1 eye
A
- they weren’t mutated
- pregnant sheep were eating plants that blocked developmental neural pathways that split brain into two lobes
3
Q
what does over activation of sonic hedgehog pathway cause
A
- basal cell carcinomas
4
Q
what is sonic hedgehog pathway?
A
- required in development of embryo
- if it stays switched on it causes cancer in humans
5
Q
how do the sheeps relate to cancer
A
- could they use the cabbage to switch off the sonic hedgehog pathway to switch off cancer?
6
Q
what happened with the clinical trial
A
- the drug worked
- they didnt have enough participants
- those that could participate wouldnt because when drug was approved they wouldnt be able to afford it anymore
