Ondansetron

Question 1

Presentation

Answer 1

Wafer
4mg orally dissolving tablet
IV
8mg in 4mL glass ampoule 
IV AT SLOW PUSH OVER 30 SECONDS

Question 2

Primary emergency indications

Answer 2

1. Undifferentiated nausea and vomiting
2. Prophylaxis for spinally immobilized or eye injured patients
3. Vestibular nausea in patients <21 years of age

Question 3

Contraindications

Answer 3

1. History of hypersensitivity
2. Concurrent Apomorphine use
3. Known Long Q-T syndrome
4. Hypokalaemia or hypomagnesamia

Question 4

Precautions

Answer 4

1. Patients with liver disease should not receive more than 8mg/day
2. Care taken with patients on diuretics who may have an electrolyte imbalance
3. Ondansetron contains aspartame and should not be given to patients with phenylketonuria
4. Concurrent use of Trimadol
5. Pregnancy

Question 5

Onset

Answer 5

Dissolving tablet
Onset: 2 minutes

Peak: 20 minutes

Duration: 120 minutes

IV
Onset: 5 minutes
Peak 10 minutes
Duration: 2.5-6 hours. 
IV at SLOW PUSH 30 SECONDS