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Pharmacotherapy IV > Oncology side effects > Flashcards

Oncology side effects Flashcards

1
Q

Erlotinib/Gefitinib

A

Fatigue, rash(good), diarrhea

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2
Q

Lapatinib

A

CHF, N/V/D

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3
Q

Imatinib

A

N/V, edema, neutropenia/thrombocytopenia

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4
Q

Vemurafenib

A

arthralgias, skin lesions

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5
Q

Trametinib

A

rash, diarrhea, lymphedema

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6
Q

CDK4/6

A

fatigue, N/V, neutropenia

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7
Q

Antimetabolites (in general)

A

myelosuppression

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8
Q

Anthracyclines

A

Cardiotoxicity

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9
Q

Which anthracycline has the worst cardiotoxicity?

A

Daunorubicin

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10
Q

Bleomycin

A

Pulmonary toxicity

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11
Q

Vinca alkaloids

A

Peripheral neuropathy and myelosuppression

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12
Q

Which vinka alkaloid has dose-limiting neurotoxicity?

A

Vincristine

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13
Q

Erubulin

A

Low neurotoxicity (compared to vinka alkyloids)

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14
Q

Taxanes

A

Myelosuppression & neurotoxicity

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15
Q

Epothilones

A

Neurotoxicty

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16
Q

Alkylating agents (in general)

A

Second malignancies; N/V, myelosuppression

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17
Q

Cyclophosphamide

A

Hemorrhagic cystitis

Less bone marrow toxicity

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18
Q

Ifosfamide

A

Hemorrhagic cystitis

CNS toxicity

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19
Q

Nitrosoureas

A

Delayed myelosuppression

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20
Q

Busulfan

A

Pulmonary fibrosis

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21
Q

Dacarbazine

A

Mild bone marrow toxicity

Severe N/V

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22
Q

Cisplatin

A 
Nephrotoxicitiy (dose-limiting)
ototoxicity
Neuropathy
N/V
Minimal myelosuppression
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23
Q

Carboplatin

A

Bone marrow suppression

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24
Q

Oxaliplatin

A

Sensory neuropathy

25
Trastuzumab
Flu-like symptoms CHF Hypersensitivity
26
Cetuximab
Severe infusion reaction Rash (good) asthenias Fever
27
Panitumumab
Rash, diarrhhea | NO infusion reaction
28
Rituximab
Flu-like symptoms Mucocutaneous reactions Lymphopenia Hypersensitivity reactions
29
Bevacizumab
Hemorrhages DVT GI perforations Wound healing
30
TDMI
Thrombocytopenia Hepatotoxicity Herceptin ADEs
31
Ipilimumab
Inflammation (GI, dermatitis, neuropathy)
32
Sipuleucel T
Flu-like symptoms, stroke (maybe)
33
Interleukin
Fever, malaise, anorexia, fatigue
34
Interferon - alpha
Flu-like symptoms, weight loss, fatigue
35
Romidepsin
Infections
36
Belinostat
N/V, fatigue, anemia
37
Azacytidine
Myelosuppression
38
Thalidomide
Teratogen Neuropahty Fatigue DVT
39
Lenalidomide
TLS Tumor flare Hepatotxicity SPM
40
Bortezomib
Neuropathy
41
Omacetaxine
Myelosuppression N/v/d fatigue
42
Asparaginase
Hypersensitivity | NO bone marrow suppression!
43
Exemastane
Hot flashes edema/fluid retention Increased cholesterol
44
Letrozole/anastrozole
Hot flashes Bone resorption (Fracutres) Asthenia bone/join/muscle pain
45
SERM
Blood clots Bone saving hot flashes Endometrial cancer
46
SERD
Hot flashes
47
Leuprolide/Geneserolide (F)
Hot flashes Sexual dysfunction Tumor flare
48
Leuprolide/geneserolide (M)
Gynecomastia Sexual dysfunction Tumor flare
49
Abarerlix/degarelix
Gynecomastia | Sexual dysfunction
50
Tamoxifen metabolism
CYP2D6 (activating)
51
Panitmumab/cetuximab gene
KRAS - must be negative for mutations
52
5-FU metabolism
DPD
53
6-MP metabolism
TPMT
54
6-TG metabolism
TPMT
55
Osimertinib mutation
T790M
56
Sorafenib mutation
BRAF
57
Vemurafenib/dabrafenib mutation
BRAF V600M
58
Irinotecan metabolism
UGT1A1
59
Ponatinib mutation
T315I

Pharmacotherapy IV (5 decks)

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