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Pharmacotherapy IV > Oncology Clinical > Flashcards

Oncology Clinical Flashcards

1
Q

Which chemo for breast cancer non-metastatic?

A

Doxorubicin & Cyclophosphamide (AC)
add Paclitaxel if LN+
add trastuzumab if HER2+

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2
Q

Which chemo for metastatic breast cancer?

A

Single agent chemo - many options (doxorubicin, paclitaxel, etc)

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3
Q

Which chemo for metastatic HER2+ breast cancer?

A

Trastuzumab
Pertuzumab
Docetaxel

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4
Q

What chemo for colorectal cancer?

A

FOLFOX
CapeOx
FOLFIRI

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5
Q

What chemo for SCLC? (limited)

A

cisplatin + etoposide

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6
Q

What chemo for NSCLC? non-metastatic

A

Carboplatin + Paclitaxel
Cisplatin + Etoposide
Cisplatin + gemcitabine or taxanes (advanced)

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7
Q

What chemo for ovarian cancer?

A

paclitaxel & carboplatin

paclitaxel & cisplatin if IP

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8
Q

What chemo for cervical cancer?

A

carboplatin doublets (paclitaxel, vinorelbine, gemcitabine, topotecan) + bevacizumab + pembrolizumab

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9
Q

What chemo for melanoma?

A

NONE

but dacarbazine or TMZ if you really want to

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10
Q

What chemo for prostate?

A

Docetaxel (+ prednisone if MCRPC)

Cabazitaxel - second line

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11
Q

What chemo for Hodgkin lymphoma?

A

ABVD

Doxorubicin, bleomycin, vinblastine, dacarbazine

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12
Q

What chemo for Hodgkin lymphoma?

A

ABVD

Doxorubicin, bleomycin, vinblastine, dacarbazine

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13
Q

What chemo for follicular NHL in elderly patients?

A

Rituximab

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14
Q

What chemo for DLBCL?

A

R-CHOP

Rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone

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15
Q

What chemo for Burkitt Lymphoma?

A

The weird ones - HyperCVAD, etc

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16
Q

What chemo for Richter’s syndrome with follicular NHL?

A

Doxorubicin-based

17
Q

What chemo for CML?

A

None - use TKIs

AML/ALL if it progresses to blast/accelerated

18
Q

What chemo for MM?

A

Induction: 3-drug therapy - bortezomib/dexamethosome + lenalidomide/cyclophosphamide/doxorubicin
Consolidation: High-dose chemotherapy/stem cell transplant

19
Q

What chemo for CLL?

A

Elderly/frail/comorbidities: Chlorambucil + obinumuzumab or ibrutinib
Mutation 17p: ibrutinib
Normal: Fludaribine, cyclophosphamide, rituximab

20
Q

What chemo for MDS?

A

Deletion 5q: Lealidomide
Low-risk: ESA/IST (Antithymocyte or cyclosporine), hypomethylating agent
High-risk: AML chemo + Stem cell transplant/hypomethylating agent

21
Q

What chemo for AML?

A

Induction: Cytarabine + Anthracycline (7+3)
Consolidation: High-dose cytarabine (with eye drop)
Transplant

22
Q

What chemo for ALL?

A

Induction: 4-drug regimen containing steroid, anthracycline, vincristine, maybe pegasus
Consolidation:
Maintenance: Methotrexate, 6-MP, prednisone, vincristine

23
Q

What chemo for ALL?

A

Induction: 4-drug regimen containing steroid, anthracycline, vincristine, maybe pegasus
Consolidation: same
Maintenance: Methotrexate, 6-MP, prednisone, vincristine

24
Q

What chemo for APL?

A

Tretinoic acid + arsenic

25
Q

R/R ALL?

A

Blinatumomab (or some other stuff)

26
Q

Treatment ALL mutation FTL3?

A

Midostaurin

27
Q

What’s different with ALL + Philadelphia chromosome?

A

Add TKI (and prognosis is worse)

28
Q

Relapsed HL?

A

High dose chemo and stem cell transport

29
Q

Relapsed DLBCL?

A

CAR T therapy

30
Q

AIDS-related lymphoma?

A

CHOP or DA-EPOCH

31
Q

R/R MM?

A

Same 6 drug categories as before (proteasome inhibitors, Imim, steroids, mabs, etc)
Mabs are elotuzumab and daratumumab

32
Q

What chemo in SCLC (extensive)?

A

Cisplatin/carboplatin + etoposide

33
Q

Recurrent SCLC?

A

No platinum if relapse within 6 months of initial treatment

Otherwise repeat regimen

34
Q

Mutation negative non-squamous NSCLC metastatic chemo?

A

Carboplatin + pemetrexed + pembrolizumab + bevacizumab

Pharmacotherapy IV (5 decks)

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