Oncology Clinical Flashcards by Blade Joneson

Which chemo for breast cancer non-metastatic?

Doxorubicin & Cyclophosphamide (AC)
add Paclitaxel if LN+
add trastuzumab if HER2+

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Which chemo for metastatic breast cancer?

Single agent chemo - many options (doxorubicin, paclitaxel, etc)

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Which chemo for metastatic HER2+ breast cancer?

Trastuzumab
Pertuzumab
Docetaxel

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What chemo for colorectal cancer?

FOLFOX
CapeOx
FOLFIRI

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What chemo for SCLC? (limited)

cisplatin + etoposide

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What chemo for NSCLC? non-metastatic

Carboplatin + Paclitaxel
Cisplatin + Etoposide
Cisplatin + gemcitabine or taxanes (advanced)

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What chemo for ovarian cancer?

paclitaxel & carboplatin

paclitaxel & cisplatin if IP

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What chemo for cervical cancer?

carboplatin doublets (paclitaxel, vinorelbine, gemcitabine, topotecan) + bevacizumab + pembrolizumab

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What chemo for melanoma?

NONE

but dacarbazine or TMZ if you really want to

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What chemo for prostate?

Docetaxel (+ prednisone if MCRPC)

Cabazitaxel - second line

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What chemo for Hodgkin lymphoma?

ABVD

Doxorubicin, bleomycin, vinblastine, dacarbazine

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What chemo for Hodgkin lymphoma?

ABVD

Doxorubicin, bleomycin, vinblastine, dacarbazine

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What chemo for follicular NHL in elderly patients?

Rituximab

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What chemo for DLBCL?

R-CHOP

Rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone

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What chemo for Burkitt Lymphoma?

The weird ones - HyperCVAD, etc

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What chemo for Richter’s syndrome with follicular NHL?

Doxorubicin-based

What chemo for CML?

None - use TKIs

AML/ALL if it progresses to blast/accelerated

What chemo for MM?

Induction: 3-drug therapy - bortezomib/dexamethosome + lenalidomide/cyclophosphamide/doxorubicin
Consolidation: High-dose chemotherapy/stem cell transplant

What chemo for CLL?

Elderly/frail/comorbidities: Chlorambucil + obinumuzumab or ibrutinib
Mutation 17p: ibrutinib
Normal: Fludaribine, cyclophosphamide, rituximab

What chemo for MDS?

Deletion 5q: Lealidomide
Low-risk: ESA/IST (Antithymocyte or cyclosporine), hypomethylating agent
High-risk: AML chemo + Stem cell transplant/hypomethylating agent

What chemo for AML?

Induction: Cytarabine + Anthracycline (7+3)
Consolidation: High-dose cytarabine (with eye drop)
Transplant

What chemo for ALL?

Induction: 4-drug regimen containing steroid, anthracycline, vincristine, maybe pegasus
Consolidation:
Maintenance: Methotrexate, 6-MP, prednisone, vincristine

What chemo for ALL?

Induction: 4-drug regimen containing steroid, anthracycline, vincristine, maybe pegasus
Consolidation: same
Maintenance: Methotrexate, 6-MP, prednisone, vincristine

What chemo for APL?

Tretinoic acid + arsenic

R/R ALL?

Blinatumomab (or some other stuff)

Treatment ALL mutation FTL3?

Midostaurin

What's different with ALL + Philadelphia chromosome?

Add TKI (and prognosis is worse)

Relapsed HL?

High dose chemo and stem cell transport

Relapsed DLBCL?

CAR T therapy

AIDS-related lymphoma?

CHOP or **DA-EPOCH**

R/R MM?

Same 6 drug categories as before (proteasome inhibitors, Imim, steroids, mabs, etc) Mabs are elotuzumab and daratumumab

What chemo in SCLC (extensive)?

Cisplatin/carboplatin + etoposide

Recurrent SCLC?

No platinum if relapse within 6 months of initial treatment | Otherwise repeat regimen

Mutation negative non-squamous NSCLC metastatic chemo?

Carboplatin + pemetrexed + pembrolizumab + bevacizumab