Oncology Nursing Flashcards
About how many women will develop cancer?
1/3
About how may men will develop cancer?
1/2
Cancer contributes to _/4 deaths.
1
Cancer ____ to heart disease as the most common cause of death.
2nd
Cancer will grow as long as it has ____ and _____.
nutrients and space
What is a cancer cell?
uncontrollable growth of irregular cells
Disorganized growth
dysplasia
increased cellularity
hyperplasia
abnormal appearing of cells
does not mean malignant
metaplasia
variance of size and shape of cell
pleomorphism
Good: has appearance of cell they originated from
Bad: Cannot tell where it came from (progressed cancers)
Differentiation
Cancer Cells:
- poor cell differentiation
- Invades other tissues
- Grow at new sites
- Avoid immune system
- Autonomy
Study of cancer
idiology
stops cells from proliferating
tumor suppressor genes
How do cancer cells get started?
- Exposure to carcinogens
- initiation
- promotion
- progression
- metastasis
Exposure to Carcinogens:
- incomplete-?
- complete-?
Incomplete- requires same cell to be exposed again after initiation.
Complete- directly causes the cancer
3 Stage Theory:
- initiation-?
- promotion-?
- progression-?
- Initiation- start with altered cell
- Promotion- enhances, alters, and lets it change
- Progression- neoplasm (new cell)
oncogene
controls for cancer cell
proto oncogene
controls proliferation of a normal cell
the grade of the cell = ?
the level of differentiation
How do cancers grow?
- Reproducing cells
2. Doubling time
Doubling time:
30 doublings = ?
1 cm
What is the earliest a cancer can be detected on an x-ray?
30 doublings (1 cm)
How many doublings lead to death?
40
Cancer can also be detected by:
A change in blood counts
Cancer cells have to complete the cell cycle.
Do they have a restriction?
no
What is doubling time?
The time it takes for the cell to double in size
Is a tumor cell just one type of cell?
What is it called?
no
Tumor Heterogeneity
How do cancers metastasize?
5 ways
- Invasion of adjacent tissues
- Enter blood and lymph vessels ***
- Invasion/ evasion of immune system
- Reentrance into distant tissue
- Implantation of malignant cells in new tissue AKA seeding
when cancer cells break away from original tumor and are in blood cells
intravasation
certain tumor cells go to a certain distant site
homing
tumor creates its own blood supply
angiogenesis
Common Metastatic Sites of Primary Tumors:most to least
lung
liver, adrenal glands, bone, brain
Common Metastatic Sites of Primary Tumors:most to least
breast
lymph, bone, lung, liver
Common Metastatic Sites of Primary Tumors:most to least
stomach
liver
Common Metastatic Sites of Primary Tumors:most to least
anus
liver, lungs
Common Metastatic Sites of Primary Tumors:most to least
bladder
lungs, bone, liver
Common Metastatic Sites of Primary Tumors:most to least
prostate
bone, liver, lungs
Common Metastatic Sites of Primary Tumors:most to least
Uterine cervix
lungs, bone, liver
Common Metastatic Sites of Primary Tumors:most to least
colon
liver (direct hepatic drainage)
What are the three patterns of cancer occurrence?
- Sporadic ***
- Inherited
- Familial cancer
certain cancers happen in families- not genetic
prone to that type of disease
familial cancer
a faulty repair gene
5% of breast cancer
inherited