Oncology

Question 1

What are MRI findings associated with methotrexate related leukoencephalopathy?

Answer 1

• White matter changes particularly in the centrum semiovale.
• Usually reversible.

Question 2

What is the effect of a germline mutation in p53?

Answer 2

• p53 is a tumour suppressor gene.
• Increased risk of soft tissue sarcoma, carcinoma of the breast, adrenal cortical carcinoma, brain tumours, leukaemia and other malignancies.
• If there is familial clustering classified as Li-Fraumeni syndrome.

Question 3

What is Hutchinsons syndrome?

Answer 3

• Limping and irritability in a young child associated with bone and bone marrow metastases and neuroblastoma.