Oncology

Question 1

MC metabolic disorder in patients with cancer

Answer 1

Hypercalcemia

Due to overproduction of PTHrP

Mostly seen in

• Myeloma
• Breast Ca

Intermediate in
- Non small cell lung Ca

Question 2

Finger clubbing is mostly seen in which type of lung Ca

Answer 2

Non small cell lung Ca

Question 3

Erythropoietin secreting tumours

Polycythemia

Answer 3

Kidney
Hepatoma
Cerebellar hemangioblastoma
Uterine fibroids

Question 4

Hormones secreted by SCLC

Answer 4

ADH - Hypo Na

ACTH - Cushing’s syndrome

Question 5

Hormone secreted by NSCLC

Answer 5

PTHrP

Question 6

Neurological paraneoplastic sydromes - Clinical presentations

Answer 6

Peripheral neuropathy 
Encephalomyelitis 
Cerebellar degeneration - Ataxia
Retinopathy 
Lambert Eaton syndrome 
Dermatomyositis & Polymyositis

Question 7

Most common primary tumours that metastasise to brain

Answer 7

Lung
Breast
Melanoma
Colon

Question 8

Malignant pleural effusions

Answer 8

Causes

• Lung Ca
• Breast Ca

C/F

• Dyspnoea
• Cough
• Chest discomfort - dull or pleuritic

Question 9

Investigations in case of malignant pleural effusion

Answer 9

Pleural aspirate - malignant cells

Malignant effusions

• blood stained
• exudate

Question 10

Cutaneous manifestations of cancer

Answer 10

Pruritus

• Lymphoma, Leukemia
• CNS tumours

Acanthosis nigricans
- Gastric Ca

Vitiligo
- Malignant melanoma

Pemphigus

• Lymphoma
• Kaposi’s sarcoma
• Thymic tumours

Dermatitis herpatiformis
- GI lymphoma