Hematology Flashcards
Bacterial infection causing lymphocytosis
Pertussis
Kostmann’s syndrome
Congenital neutropenia
Fungal infections causing lymphadenopathy
Histoplasmosis
Coccidiodomycosis
Fungal causes of splenomegaly
Histoplasmosis
Causes of basophilia
Myeloproliferative diseases - polycythemia, CML
Inflammation - acute hypersensitivity, IBD
Iron deficiency
Causes of relative(low volume) erythrocytosis
Smoking
Alcohol excess
Obesity
Diuretics
Gaisbock’s syndrome
Drugs that induce neutropenia
Anti HTN - captopril, enalapril,
nifedipine
Antibiotics - penicillins, cephalosporins,
sulphonamides
Antithyroids - carbimazole, propylthiouracil
Anti inflammatory - gold, penicillamine
Anti convulsants - phenytoin, carbamazepine
sodium valproate
Non thrombocytopenic purpura
Senile
Factitious
Vasculitis
HSP
Paraproteinemias
Purpura fulminans - in DIC secondary to sepsis
Microangiopathic hemolytic anemia
TTP -
Hemolytic anemia Thrombocytopenia Renal failure Fever Neurological features
HUS - Prominent renal impairment, NO CNS features
Hematological manifestation of chronic arsenic poisoning
Aplastic anemia
Reactive thrombocytosis - Causes
- Chronic inflammatory disorders
- Malignancy
- Tissue damage
- Hemolytic anemias
- Post splenectomy
- Post haemorrhage
Non immune causes of acquired hemolysis
Mechanical
- Prosthetic valves
- March Hb uria
- Microangiopathic - DIC, HUS, TTP
Infection
- Intracellular organisms : Malaria
- Toxins : C.perfringens
Physical & Chemical
- Burns, Drowning
- Oxidative drugs : Dapsone
- Copper (Wilson’s disease)
Acquired abnormal membrane
- PNH
Conditions associated with secondary anti-phospholipid syndrome
RA
SLE
Systemic sclerosis
Behçet’s syndrome
Temporal arteritis
Sjögren’s syndrome
Causes of TTP
Drugs - Ticlopidine, Ciclosporin
HIV
Shiga toxins
Malignancy
Drugs causing aplastic anemia
Cytotoxic drugs
Immunosuppressants - Azathioprine
Antibiotics - Chloramphenicol, Sulfonamides
Anti-rheumatic : Pencillamine, gold, Phenylbutazone, Indometacin
Anti thyroids
Anti convulsants
