Oncology

Question 1

Gene and chromosome number for retinoblastoma

Answer 1

Rb chromosome 13

Question 2

Cancers associated with down syndrome x3

Answer 2

Leukemia
Glioma
Neurofibromatosis

Question 3

Infection related childhood cancers

Answer 3

Burkitts lymphoma- EBV
Hodgkins lymphoma- EBV
Nasopharyngeal carcinoma - EBV
Kaposi Sarcoma- HIV
Liver carcinoma - Hepatitis B

Question 4

Define neutropenic sepsis and management

Answer 4

A complication of anticancer treatment resulting in low neutrophil count
Granulocyte colony stimulating factor

Question 5

Drugs used in pre-phase (2) and why

Answer 5

Allopurinol- prevents formation of crystals from uric acid formed from cell destruction hence protecting the kidneys
Prednisolone- to destroy as many leukemia cells as possible

Question 6

Effect of chemo of the GIT system x3

Answer 6

Mouth sores
Vomiting, nausea
Chemo induced gut mucosal damage > predisposition to gram neg infections

Question 7

Side effects of: doxorubicin, cisplatin (2), cyclophosphamide, vincristine

Answer 7

D- cardiotoxicity
V- neuropathy
Cisplatin- renal failure and deafness
Cyclophoshamide- hemorrhagic cystitis