Oncology Flashcards

1
Q

Leukaemia

A

Cancer of the stem cells in the bone marrow

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2
Q

Name some types of Leukaemia

A

acute lymphoblastic leukemia (ALL) acute myeloid leukemia (AML) chronic lymphocytic leukemia (CLL) chronic myeloid leukaemia (CML)

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3
Q

What type of Leukaemia is the most common in children?

A

ALL

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4
Q

In which age group does ALL have peak incidence?

A

2-3 years

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5
Q

What is the second most common type of Leukaemia in children?

A

AML

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6
Q

In which age group does AML have peak incidence?

A

<2 years

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7
Q

Incidence of CML

A

very rare

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8
Q

Risk Factors for Leukaemia

A
  • Down’s syndrome - Kleinfelters syndrome - Radiation exposure during pregnancy - Noonan syndrome
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9
Q

Symptoms of Leukaemia

A
  • Persistent fatigue - Unexplained fever - Faltering growth - Weight loss - Night sweats - Anaemia - Petechiae and abnormal bruising - Unexplained bleeding - Abdominal pain - Generalised lymphadenopathy - Hepatosplenomegaly
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10
Q

Ix for Leukaemia

A
  • NICE recommend any child with unexplained petechiae or hepatomegaly require specialist assessment. FBC + Blood Film + Bone Marrow Biopsy
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11
Q

When should a FBC be done if you suspect Leukaemia?

A

should be done within 48 hours

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12
Q

What may FBC show for someone with Leukaemia ?

A

anaemia, leukopenia, thrombocytopenia

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13
Q

What may a blood film show for someone with Leukaemia ?

A

can show blast cells

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14
Q

What is the definitive Ix for Leukaemia ?

A

Bone marrow biopsy

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15
Q

Managment of Leukaemia

A
  • Chemotherapy
  • Potential radiotherapy and bone marrow transplant
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16
Q

Brain Tumours - are they likely to be primary or secondary children?

A

These are almost always primary in children

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17
Q

What is the leading cause of childhood cancer deaths in the UK?

A

Brain Tumours

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18
Q

Name some types of Brain Tumours

A

Astrocytoma, Medulloblastoma, Ependyoma, Brainstem glioma, Craniopharyngioma

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19
Q

Brain Tumours : Astrocytoma severity ?

A
  • varies from benign to highly malignant
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20
Q

Brain Tumours : Medulloblastoma - distribution ?

A

arises in the midline of the posterior fossa and may seed through the CNS via the CSF giving spinal metastases

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21
Q

Brain Tumours : Ependymoma - location ?

A
  • mostly in the posterior fossa where it behaves like medulloblastoma
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22
Q

Brain Tumours : Craniopharyngioma - origin?

A

developmental tumour arising from an embryological remnant

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23
Q

Symptoms of Brain Tumours are often related to raised ____

A

ICP

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24
Q

Symptoms of Brain Tumours

A

Headache worse on waking, coughing, straining or bending forward along with papilloedema - Focal neurological signs may be detected - Back pain, Peripheral weakness of arms/legs or Bladder/bowel dysfunction can also be present depending upon the level of the lesion.

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25
Q

Ix for Brain Tumours

A

MRI scan

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26
Q

Managment of Brain Tumours

A

Surgery is usually the first treatment and aimed at treating hydrocephalus
- Chemo and radio depends upon the tumour type and age of the patient.

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27
Q

Wilms Tumour origin

A

Originating from embryonal renal tissue

28
Q

What is the most common renal tumour of children?

A

Wilms Tumour

29
Q

When does Wilms Tumour often present?

A

most often presents before 5 years of age

30
Q

Symptoms of Wilms Tumour

A

Abdominal pain
- Anorexia
- Haematuria

31
Q

Signs of Wilms Tumour

A

Large abdominal mass, often incidentally found in an otherwise well child - HTN

32
Q

Ix for Wilms Tumour

A

CT/MRI are often characteristic and show the intrinsic renal mass

33
Q

Management of Wilms Tumour

A

Initial chemotherapy followed by delayed nephrectomy

34
Q

Neuroblastoma

A

Tumour arising from the neural crest tissue in the adrenal medulla and sympathetic nervous system. - It is a biologically unusual tumour

35
Q

When does Neuroblastoma usually occur ?

A

usually occurs before 5 years of age

36
Q

What is the general prognosis of Neuroblastoma ?

A

Generally, prognosis is very good with more than 80% of patients being cured

37
Q

Symptoms of Neuroblastoma

A
  • Abdominal mass - Pallor - Weight loss - Hepatomegaly
  • Bone pain
  • Limp
  • Cervical lymphadenopathy
  • Periorbital bruising
  • Skin nodules
38
Q

Ix for Neuroblastoma

A

Raised urinary catecholamine levels
Biopsy
Bone marrow sampling

39
Q

Management of Neuroblastoma

A
  • Surgery can often be curative when there is no metastatic disease - Metastatic disease will need chemotherapy, surgery and radiotherapy
40
Q

Retinoblastoma

A

Malignant tumour of retinal cells

41
Q

Retinoblastoma accounts for __% of visual impairement in children

42
Q

Retinoblastoma can be either ____ or _____

A

unilateral or bilateral.

43
Q

Causes of bilateral Retinoblastoma

A

Hereditary

44
Q

Which Chromosome is involved with inheritance of Retinoblastoma

A

Retinoblastoma susceptibility is on chromosome 13 with dominant inheritance

45
Q

Most cases of Retinoblastoma present in the first ___ years of life

46
Q

Symptoms of Retinoblastoma

A

White pupillary reflex replaces the red one - Squint

47
Q

Ix for Retinoblastoma

A

MRI and examination under anaesthetic

48
Q

Management of Retinoblastoma

A

Aim is to cure but still preserve vision - Treatment is based around ophthalmological findings - Chemotherapy

49
Q

Why is Chemotherapy used in Retinoblastoma tx?

A

Chemotherapy is used to shrink the tumour, particularly in bilateral disease and then followed by local laser treatment.

50
Q

Prognosis of Retinoblastoma

A

Most patients are cured but many can be visually impaired but there is a significant risk of secondary malignancy

51
Q

What type of Sarcome is seen more often in younger children?

A

Ewing’s sarcoma is seen more often in younger children

52
Q

What type of Sarcoma is more common than Ewings?

A

Osteogenic sarcoma is more common than Ewings.

53
Q

Symptoms of Bone Tumours

A
  • Limbs are the most common site - Persistent, localised bone pain is the most common symptom otherwise patients are generally well.
54
Q

First Line Ix for Bone Tumours

A

Plain X-ray is often first line and then followed by MRI and bone scan

55
Q

Other Ix for Bone Tumours

A

Bone x rays + CT scan

56
Q

What does bone X-ray show in Bone Tumours?

A

Bone x-ray shows destruction and variable periosteal new bone formation

57
Q

What is a characteristic feature of Ewing’s Sarcoma on X ray?

A

there is often a substantial soft tissue mass (onion skin appearance)

58
Q

What is a CT scan used for in Bone Tumours investigation?

A

used to assess for lung metastasis

59
Q

Managment of Bone Tumours

A

Combination chemotherapy is given before surgery

60
Q

Management of Ewing’s Sarcoma

A

Combination chemotherapy is given before surgery - In Ewings, radiotherapy is also used, especially if surgical resection is impossible.

61
Q

Hepatoblastoma

A
  • Primary malignancy liver tumour
62
Q

Symptoms of Hepatoblastoma

A

Usually presents with abdominal distension or with a mass, pain and jaundice is usually rare

63
Q

Ix of Hepatoblastoma

A

Elevated a-fetoprotein is detected in nearly all cases of hepatoblastoma.

64
Q

Managment of Hepatoblastoma

A

Management includes chemotherapy, surgery and in inoperable cases, liver transplantation is needed

65
Q

Prognosis of Hepatoblastoma

A

Prognosis is generally good and children will be cured