Oncology

Question 1

Cancer med dosing is based off of what?

Answer 1

BSA mg/m2

Question 2

Which cancer med doesn’t dose based on BSA?

Answer 2

carboplatin - AUC and CrCl

Question 3

Most common reaction with Mabs

Answer 3

anaphylaxis(injection) or SJS

-pretreat with APAP/antihist, steroid

Question 4

Chemo with least bone marrow suppression?

Answer 4

asparaginase

bleomycin

vincristine

Question 5

What is used for methotrexate toxicity?

Answer 5

leucovorin

Question 6

Mab antibody type

Answer 6

omab = murine/mouse

umab = human

ximab = chimeric (some human, some not)

zumab = mostly human, some not

Question 7

most tyrosine kinase inhibitors (-nib) are what dosage form?

Answer 7

PO oral

Question 8

TKI class SE

Answer 8

diarrhea and rash

QTc prolongation

all CYP3A4

Question 9

Chemo with highest N/V(emetic) risk

Answer 9

carboplatin

cisplatin

ifosfamide

oxaliplatin

Question 10

Emend generics

Answer 10

aprepitant (PO)

fosaprepitant (IV)

Question 11

Cannabinoid anti-emetics

Answer 11

dronabinol (PO) - CIII

nabilone (PO) (Cesamet) - CII

Question 12

List of alternative or add-ons for anti-nausea

Answer 12

dexamethasone

haloperidol

lorazepam

olanzapine (Zyprexa)

prochlorperazine

promethazine

scopolamine

Question 13

GCSFs (stimulate Neutrophils)

Answer 13

leukine (Sargramostim)

neupogen (FIlgrastim)

neulasta (Pegfilgrastim)

usually given 24-72 hrs after chemo

Question 14

ESAs - Stimulate RBCs

Answer 14

epoetin (Procrit)

darbepoetin (Aranesp)

only give if hemoglobin < 10

REMS ended 2017