Oncologic emergencies Flashcards
Types of body systems effected by oncologic emergencies
– Metabolic, neurologic, cardiovascular, respiratory, genitourinary,
gastrointestinal, hematological
Causes of oncologic emergencies
– Increased tumor size
– Tumors may secrete substances that mimic substances in the body
How do oncologic emergencies usually present
May be first s/s of cancer
May be sign cancer has advanced
What are the treatment goals in an oncologic emergency
• Immediate intervention to prevent loss of life or quality of life
• STAT aggressive supportive measures followed by definitive treatment
of the underlying malignancy
3 types of metabolic emergencies
Tumor lysis syndrome
SIADH
Hypercalcemia
Risk factors of tumor lysis syndrome
acute leukemias most common Testicle cancer Small cell lung CA Breast CA aggressive lymphoma
What happens in tumor lysis syndrome
Either as a result or treatment or as a result of worsening tumor, cells lyse and release contents which exceeds capacity for kidneys elimination
How does tumor lysis syndrome present
labs and manifestations
Increased K, cramps, N/D paralysis, paresthesias, ECG changes
Hyperphosphatemia: Oliguria/anuria/azotemia
Hypocalcemia: Tinnitus, twitching, seizures, parathesias and hypotension
Hyperuremia: N/V, AMS, edmea
Interventions for tumor lysis syndrome
Aggressive IV hydration, to regulate electrolyte levels and perfuse kidney
Allapurinol 300 mg PO: prevent uric acid synthesis
Rasburicase: 30 min infusion for TLS
Hemodialysis for acute episodes
SIADH
Too much antidieuretic hormone the prevalence of 1-2% of persons with cancer
Risk factors of SIADH and medications that can cause this
Small-cell lung cancer (60%), pancreatic, prostate, brain cancers
• Is adverse effect of cyclophosphamide (Cytoxan), vincristine, cisplatin
What happens in the body during SIADH
Water intoxication
ADH is secreted without response to usual feedback mechanism
Kidneys continue to retrun water to the body which dilutes the Na levels
SIADH symptoms when it is slow onset
• Subtle mental and cognitive changes, i.e. memory loss, apathy, impaired abstract thinking • Fatigue, myalgia • Headache • Thirst
SIADH symptoms when it is rapid/severe onset
Asterixis (flap/tremor of hand when wrist extended)
Confusion
Seizures, coma
Diagnostic findings of SIADH
Serum Na <130 mmoL/L
Urine Na >20 mmoL/L
Urine osmolality exceeds that of plasma
SIADH Interventions
Treat the tumor—combination chemotherapy; RT
Fluid Restriction (<1000mL or <500 mL if there is a poor response
Declomycin in divided doses is given for refractory low Na
3%hypertonic Na by slow infusion to treat Neurosymptoms (seizure/coma)
Furosemide (Lasix) w/ normal saline infusion
how common is Hypercalcemia and what is the survival rate
• Is most common metabolic emergency; experienced by 25% of persons
with cancer
• 50% of patients diagnosed will die within one month of onset
• Mean survival 1-6 months
What is the cause of hypercalcemia
& special consideration
Altered calcium metabolism in bones kindeys, intestines esp in the presence of metastatic disease
Parathyroid hromone like substance screted by cancer cells (paraneoplastic syndrome)
Renal func/dehydration/physical activity
What are the diagnostic criteria fo hypercalcemia
Calcium levels of >11
K, Na, PO4 decreased
BUN/Creatinine Increased
What are the clinical manifestations of hypercalcemia
Loss of appetite Nausea and vomiting Constipation and abdominal pain Increased thirst and frequent urination Fatigue, weakness, and muscle pain Confusion, disorientation, and difficulty thinking Headaches Depression
Systems issues with hypercalcemia
Kidney stones Irregular heartbeat Myocardial Infarction Loss of consciousness Coma
What do you assess in hypercalcemia
Assess levels of dehydration, renal function and CV status