Oncogenes/Tumor Suppressor Genes Flashcards
ALK
Receptor Tyrosine Kinase Lung Adenocarcinoma (lung kinase)
BCR-ABL
Tyrosine Kinase
CML, ALL
BCL-2
Inhibits apoptosis
Follicular and diffuse B cell lymphomas
BRAF
Serine/threonine Kinase
Melanoma, Non-Hodgkin lymphoma, papillary thryoid carcinoma
c-KIT
Cytokine receptor
Gastrointestinal stromal tumor
c-MYC
Transcription Factor
Burkitt lymphoma
HER2/neu (c-erbB2)
Receptor Tyrosine Kinase
Breast and Gastric carincomas
JAK2
Tyrosine Kinase
Chronic Myeloproliferative Disorders
KRAS
GTPase
Colon, lung, pancreatic cancers
MYCL1
Transcription Factor
Lung tumor
N-myc (MYCN)
Transcription Factor
Neuroblastoma
RET
Receptor Tyrosine Kinase
MEN2A/2B, papillary thyroid carcinoma
APC
Negative Regulator of beta-catenin/WNT pathway Colorectal cancer (FAP)
BRCA1/2
DNA repair protein
Breast, ovarian, pancreatic
CDKN2A
p16 (blocks G1 to S)
Melanoma, pancreatic cancer
DCC
DCC (deleted in colon cancer)
SMAD4 (DPC4)
DPC (deleted in pancreatic cancer)
MEN1
Menin
MEN1
NF1
Neurofibromin (Ras GTPase activating protien)
Neurofibromatosis 1
NF2
Merlin (Schwannomin) protein
NF type 2
PTEN
Negatively Regulates PI3k/AKT pathway
Breast, Endometrial, Prostate cancer
Rb
Inhibits E2F (blocks G1 to S) Retinoblastoma, osteosarcoma
TP53
p53 (activates p21 (blocks G1 to S))
Most cancers, Li-Fraumeni Syndrome (Sarcoma, Breast, Leukemia, Adrenal Gland (SBLA))
TSC1
Hamartin
Tuberous Sclerosis
TSC2
Tuberin
Tuberous Sclerosis
VHL
Inhibits hypoxia inducible factor 1a
von Hippel-Lindau disease
WT1
Transcription factor that regulates urogenital development Wilms Tumor (nephroblastoma)
