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Pathology > Oncogenes/Tumor Suppressor Genes > Flashcards

Oncogenes/Tumor Suppressor Genes Flashcards

1
Q

ALK

A 
Receptor Tyrosine Kinase
Lung Adenocarcinoma (lung kinase)
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2
Q

BCR-ABL

A

Tyrosine Kinase

CML, ALL

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3
Q

BCL-2

A

Inhibits apoptosis

Follicular and diffuse B cell lymphomas

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4
Q

BRAF

A

Serine/threonine Kinase

Melanoma, Non-Hodgkin lymphoma, papillary thryoid carcinoma

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5
Q

c-KIT

A

Cytokine receptor

Gastrointestinal stromal tumor

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6
Q

c-MYC

A

Transcription Factor

Burkitt lymphoma

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7
Q

HER2/neu (c-erbB2)

A

Receptor Tyrosine Kinase

Breast and Gastric carincomas

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8
Q

JAK2

A

Tyrosine Kinase

Chronic Myeloproliferative Disorders

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9
Q

KRAS

A

GTPase

Colon, lung, pancreatic cancers

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10
Q

MYCL1

A

Transcription Factor

Lung tumor

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11
Q

N-myc (MYCN)

A

Transcription Factor

Neuroblastoma

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12
Q

RET

A

Receptor Tyrosine Kinase

MEN2A/2B, papillary thyroid carcinoma

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13
Q

APC

A 
Negative Regulator of beta-catenin/WNT pathway
Colorectal cancer (FAP)
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14
Q

BRCA1/2

A

DNA repair protein

Breast, ovarian, pancreatic

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15
Q

CDKN2A

A

p16 (blocks G1 to S)

Melanoma, pancreatic cancer

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16
Q

DCC

A

DCC (deleted in colon cancer)

17
Q

SMAD4 (DPC4)

A

DPC (deleted in pancreatic cancer)

18
Q

MEN1

A

Menin

MEN1

19
Q

NF1

A

Neurofibromin (Ras GTPase activating protien)

Neurofibromatosis 1

20
Q

NF2

A

Merlin (Schwannomin) protein

NF type 2

21
Q

PTEN

A

Negatively Regulates PI3k/AKT pathway

Breast, Endometrial, Prostate cancer

22
Q

Rb

A 
Inhibits E2F (blocks G1 to S)
Retinoblastoma, osteosarcoma
23
Q

TP53

A

p53 (activates p21 (blocks G1 to S))

Most cancers, Li-Fraumeni Syndrome (Sarcoma, Breast, Leukemia, Adrenal Gland (SBLA))

24
Q

TSC1

A

Hamartin

Tuberous Sclerosis

25
Q

TSC2

A

Tuberin

Tuberous Sclerosis

26
Q

VHL

A

Inhibits hypoxia inducible factor 1a

von Hippel-Lindau disease

27
Q

WT1

A 
Transcription factor that regulates urogenital development
Wilms Tumor (nephroblastoma)

Pathology (6 decks)

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