Oncogenes Flashcards
ERBB1 Oncogene
Affected Protein, Mechanism and Associated Tumor
Epidermal Growth Factor Receptor
Mutation
Lung Adenocarcinoma
ERBB2 Oncogene
Affected Protein, Mechanism and Associated Tumor
HER2 protein
Amplification
Breast carcinoma
ALK Oncogene Affected Proteins (2), Mechanisms (2) and Associated Tumors (2)
ALKR-EML4 fusion
Translocation
Lung Adenocarcinoma
ALKR
Mutation
Neuroblastoma
Non-Receptor Tyrosine Kinase Oncogene
Affected Protein, Mechanisms (2) and Associated Tumor
ABL
Translocation/Mutation
Chronic/Acute Leukemia
BRAF Oncogene
Affected Protein, Mechanism and Associated Tumors (3)
RAS
Translocation/Mutation
Leukemia, Melanoma, Colon carcinoma
SHH/WNT Mutation
Associated Tumor
Basal cell carcinoma
RAS Pathway
Mutation and Associated Cancers (2)
NF1 mutation
Familial neurofibromatosis Type 1, neuroblastoma
Myc Oncogene
Defect and Associated Cancer
Translocation
Burkitt Lymphoma
TP53 Oncogene
Defect and Associated Cancer
Li-Fraumeni Syndrome
Associated with most cancers
RB Gene Mutation
Familial Syndrome and Associated Tumors (5)
Familial Retinoblastoma Syndrome
Retinoblastoma
Lung/Breast/Colon Carcinomas
Osteosarcoma
APC Gene Mutation
Familial Syndrome and Cancers (4)
Familial colonic polyps
Stomach, colon, pancreas carcinomas
Melanoma
PTCH Gene Mutation
Familial Syndrome and Cancers (2)
Gorlin syndrome
Basal cell carcinoma and medulloblastoma
VHL Gene Mutation
Familial Syndrome and Cancer
Von Hippel Lindau syndrome
(Cerebellar, retinal and renal tumors)
Renal cell carcinoma
CDH1 Gene Mutation
Familial Syndrome and Cancers (2)
Familial gastric cancer
Gastric and Breast carcinoma
MSH Gene Mutation
Familial Syndrome and Cancers (2)
Hereditary nonpolyposis colon carcinoma
Colon and Endometrial Carcinoma
WT1 Gene Mutation
Familial Syndrome and Cancer
Familial Wilms Tumor
Leukemia
