Oncogenes

Question 1

What happens if you have a mutated oncogene?

Answer 1

Gain of function -> increased risk of cancer; need damage to only 1 allele

Question 2

ALK

Answer 2

GP: Receptor tyrosine kinase; associated with lung adenocarcinoma

Question 3

BCR-ABL

Answer 3

GP: Tyrosine kinase; associated with CML and ALL

Question 4

BCL-2

Answer 4

GP: Antiapoptotic molecule- inhibits apoptosis; assoicated with follicular and diffuse large B cell lymphoma

Question 5

BRAF

Answer 5

GP: serine/threonine kinase; associated with melanoma and non-hodgkin lymphoma

Question 6

c-KIT

Answer 6

GP: Cytokine receptor; associated with gastrointestinal stromal tumor (GIST)

Question 7

c-MYC

Answer 7

GP: Transcription factor; associated with Burkitt lymphoma

Question 8

HER2/neu (c-erbB2)

Answer 8

GP: Tyrosine kinase; associated with breast and gastric carcinoma

Question 9

JAK2

Answer 9

Tyrosine kinase; associated with chronic myeloproliferative disorders

Question 10

KRAS

Answer 10

GTPase; associated with colon cancer, lung cancer, pancreatic cancer

Question 11

MYCL1 (L-MYC)

Answer 11

Transcription factor; associated with lung tumor

Question 12

MYCN (N-MYC)

Answer 12

Transcription factor; neuroblastoma

Question 13

RET

Answer 13

Tyrosine kinase; MEN 2A and 2B, medullary thyroid cancer