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MOD > Oncogenes > Flashcards

Oncogenes Flashcards

1
Q

Category: TGF-α
Proto-oncogene
Mode of Activation
Associated Human Tumor

A

Category: TGF-α
Proto-oncogene: TGFA
Mode of Activation: Overexpression
Associated Human Tumor: Astrocytomas

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2
Q

Category: EGF-receptor Family–ERBB1
Proto-oncogene
Mode of Activation
Associated Human Tumor

A

Category: EGF-receptor Family–ERBB1
Proto-oncogene:ERBB1 (EGFR)
Mode of Activation: Mutation
Associated Human Tumor: Adenocarcinoma of lung

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3
Q

Category: EGF-receptor Family–ERRB2
Proto-oncogene
Mode of Activation
Associated Human Tumor

A

Category: EGF-receptor Family–ERRB2
Proto-oncogene: ERRB2 (HER)
Mode of Activation: Amplification
Associated Human Tumor: Breast Carcinoma

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4
Q

Category: Receptor for neurotrophic factors
Proto-oncogene
Mode of Activation
Associated Human Tumor

A

Category: Receptor for neurotrophic factors
Proto-oncogene: RET
Mode of Activation: Point Mutation
Associated Human Tumor: Multiple endocrine neoplasia 2A and B, familial medullary thyroid carcinomas

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5
Q

Category: Receptor for stem cell (steel) factor
Proto-oncogene
Mode of Activation
Associated Human Tumor

A

Category: Receptor for stem cell (steel) factor
Proto-oncogene: KIT
Mode of Activation: Point mutation
Associated Human Tumor: Gastrointestinal stromal tumors, seminomas, leukemias

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6
Q

Category: ALK receptor
Proto-oncogene
Mode of Activation
Associated Human Tumor

A

Category: ALK receptor
Proto-oncogene: ALK
Mode of Activation: Translocation, fusion gene formation, point mutation
Associated Human Tumor: Adenocarcinoma of lung, lymphomas, Neuroblastoma

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7
Q

Category: GTP-binding (G) proteins
Proto-oncogene
Mode of Activation
Associated Human Tumor

A

Category: GTP-binding (G) proteins
Proto-oncogene: RAS
Mode of Activation: Point Mutation
Associated Human Tumor: Colon, lung, and pancreatic tumors (KRAS),

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8
Q

Category: Nonreceptor tyrosine kinase
Proto-oncogene
Mode of Activation
Associated Human Tumor

A

Category: Nonreceptor tyrosine kinase
Proto-oncogene: ABL
Mode of Activation: Translocation t (9,22) defines CML
Associated Human Tumor: CML, ALL (adults)

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9
Q

Category: RAS Signal transduction
Proto-oncogene
Mode of Activation
Associated Human Tumor

A

Category: RAS Signal transduction
Proto-oncogene: BRAF
Mode of Activation: Point Mutation
Associated Human Tumor: Melanomas, leukemias, colon carcinoma, others

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10
Q

Category: JAK/STAT signal transduction
Proto-oncogene
Mode of Activation
Associated Human Tumor

A

Category: JAK/STAT signal transduction
Proto-oncogene: JAK2
Mode of Activation: Translocation
Associated Human Tumor: Myeloproliferative disorders, ALL

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11
Q

Category: Transcriptional activators–c-MYC
Proto-oncogene
Mode of Activation
Associated Human Tumor

A

Category: Transcriptional activators
Proto-oncogene: c-MYC
Mode of Activation: Translocation
Associated Human Tumor: Myeloproliferative

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12
Q

Category: Transcriptional activators–N-MYC
Proto-oncogene
Mode of Activation
Associated Human Tumor

A

Category: Transcriptional activators–N-MYC
Proto-oncogene: N-MYC
Mode of Activation: Amplication
Associated Human Tumor: Neuroblastoma

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13
Q

Category: Cylcins
Proto-oncogene
Mode of Activation
Associated Human Tumor

A

Category: Cyclins
Proto-oncogene: Cyclin D1 (CCND1)
Mode of Activation: Translocation t(11,14)
Associated Human Tumor: Mantle cell lymphoma

Mode of Activation: Amplification
Associated Human Tumor: Breast and esophageal cancer

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14
Q

Category: Cyclin-dependent
Proto-oncogene
Mode of Activation
Associated Human Tumor

A

Category: Cyclin-dependent
Proto-oncogene: CDK4
Mode of Activation: Amplification or or point mutation
Associated Human Tumor: Glioblastoma, melanoma, sarcoma

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15
Q

Tumor Nomenclature: Smooth Muscle

Benign and Malignant

A

Benign: Leiomyoma
Malignant: Leiomyosarcoma

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16
Q

Tumor Nomenclature: Striated Muscle

Benign and Malignant

A

Benign: Rhabdomyoma
Malignant: Rhadomyosarcoma

17
Q

Tumor Nomenclature: Placental Epithelium

Benign and Malignant

A

Benign: Hydatidiform mole
Malignant: Choiocarcinoma

18
Q

Tumor Nomenclature: Testicular Epithelium

Benign and Malignant

A

Malignant: Seminoma
Malignant: Embryonal carcinoma

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