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MOD > ANS Basics > Flashcards

ANS Basics Flashcards

1
Q

alpha 1: location

A

Postsynaptic effectors: vascular smooth muscle of skin and splanchnic regions (alpha 1-> think baseline)

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2
Q

alpha 1: mechanism of action

A

Gq protein, stimulation of phospholipase C, increase IP3/DAG, increase intracellular Ca

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3
Q

alpha 1: effects

A

contraction/constriction of vasculature

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4
Q

alpha 2: location

A

think inhibitory!
sympathetic postganglionic nerve terminals (autoreceptors), platelets, lipocytes, and heteroreceptors in GI tract
(rember: autoreceptors are inhibitory)

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5
Q

alpha 2: mechanism of action

A

Gi protein inhibition of adenylate cyclase and decrease in cAMP

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6
Q

alpha 2: effect

A

inhibition: (relaxation or dilation)

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7
Q

beta 1: location

A

Beta 1 -> heart!
Postsynaptic effector; SA, AV, ventricular muscle of heart, lipocytes, brain, presynapse terminals, JGA kidney, ciliary body epithelium

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8
Q

beta 1: mechanism of action

A

Increase adenylyl cyclase, increase cAMP

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9
Q

beta 1: effect

A

Excitation: increase HR, conduction velocity, contractility

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10
Q

contraction of radial muscle, iris (mydriasis) - receptor?

A

alpha 1

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11
Q

iris: contraction of sphincter muscle (miosis)

A

M2, M3

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12
Q

Relaxation of ciliary muscle

A

B2 - far vision

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13
Q

Contraction of ciliary muscle

A

M3 (M2)

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14
Q

Lacrimal gland secretion

A

alpha a little, really M3 (M2)

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15
Q

PANS heart: receptor and effects

A

M2 (M3 a little)

-counter acts all of SANS stuff, but less effect in perkinjee system

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16
Q

SANS heart: receptor and effects

A

B1 (little B2)

  • SA - increase HR
  • atria - increase contractility, conduction
  • AV - automaticity, conduction
  • Perkinjee - automaticity, conduction
  • ventricle - conduction, contractility, automaticity, pacemaker
17
Q

beta 2: location

A

Beta 2 - everything but heart

vascular smooth muscle of skeletal muscle, bronchial smooth muscle, walls of the GI tract and bladder

18
Q

beta 2: effect

A

relaxation (inhibition) - dilation of vascular smooth muscle, dilation of bronchioles, relaxation of the bladder wall

19
Q

beta 2: mech of action

A

Gs; increase adenylyl cyclase, increase cAMP

20
Q

Nn location

A

Adrenal medulla, chain ganglia, CNS

21
Q

Nm location

A

neuromuscular junction

22
Q

Nn, Nm mech of action

A

opening of Na, K channels (depolarization)

23
Q

M2 location

A

heart, some smooth muscle, CNS, presynapse

24
Q

M2 action

A

inhibitory in heart

25
Q

M3 location

A

smooth muscle and glands

26
Q

M3 action

A

excitatory in smooth muscle/glands (increase motility, increase secretion)

M3 - think secretion and contraction

27
Q

M1,3,5 mech of action

A

increase IP3/DAG -> increase Ca

28
Q

M2/M4 mech of action

A

inhibit adenylyl cyclase, decrease cAMP, also open K+ channels

29
Q

beta 3 location and mech

A

increase adenylyl cyclase in lipocytes

MOD (5 decks)

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