ANS Basics Flashcards
alpha 1: location
Postsynaptic effectors: vascular smooth muscle of skin and splanchnic regions (alpha 1-> think baseline)
alpha 1: mechanism of action
Gq protein, stimulation of phospholipase C, increase IP3/DAG, increase intracellular Ca
alpha 1: effects
contraction/constriction of vasculature
alpha 2: location
think inhibitory!
sympathetic postganglionic nerve terminals (autoreceptors), platelets, lipocytes, and heteroreceptors in GI tract
(rember: autoreceptors are inhibitory)
alpha 2: mechanism of action
Gi protein inhibition of adenylate cyclase and decrease in cAMP
alpha 2: effect
inhibition: (relaxation or dilation)
beta 1: location
Beta 1 -> heart!
Postsynaptic effector; SA, AV, ventricular muscle of heart, lipocytes, brain, presynapse terminals, JGA kidney, ciliary body epithelium
beta 1: mechanism of action
Increase adenylyl cyclase, increase cAMP
beta 1: effect
Excitation: increase HR, conduction velocity, contractility
contraction of radial muscle, iris (mydriasis) - receptor?
alpha 1
iris: contraction of sphincter muscle (miosis)
M2, M3
Relaxation of ciliary muscle
B2 - far vision
Contraction of ciliary muscle
M3 (M2)
Lacrimal gland secretion
alpha a little, really M3 (M2)
PANS heart: receptor and effects
M2 (M3 a little)
-counter acts all of SANS stuff, but less effect in perkinjee system
SANS heart: receptor and effects
B1 (little B2)
- SA - increase HR
- atria - increase contractility, conduction
- AV - automaticity, conduction
- Perkinjee - automaticity, conduction
- ventricle - conduction, contractility, automaticity, pacemaker
beta 2: location
Beta 2 - everything but heart
vascular smooth muscle of skeletal muscle, bronchial smooth muscle, walls of the GI tract and bladder
beta 2: effect
relaxation (inhibition) - dilation of vascular smooth muscle, dilation of bronchioles, relaxation of the bladder wall
beta 2: mech of action
Gs; increase adenylyl cyclase, increase cAMP
Nn location
Adrenal medulla, chain ganglia, CNS
Nm location
neuromuscular junction
Nn, Nm mech of action
opening of Na, K channels (depolarization)
M2 location
heart, some smooth muscle, CNS, presynapse
M2 action
inhibitory in heart
M3 location
smooth muscle and glands
M3 action
excitatory in smooth muscle/glands (increase motility, increase secretion)
M3 - think secretion and contraction
M1,3,5 mech of action
increase IP3/DAG -> increase Ca
M2/M4 mech of action
inhibit adenylyl cyclase, decrease cAMP, also open K+ channels
beta 3 location and mech
increase adenylyl cyclase in lipocytes
