oncogenes Flashcards by Sam Lucrezia

Q

BCR ABL

A

tyrosine kinase

CML, ALL

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Q

BCL2

A

Antiapototic molecule
follicular and undifferentiated lymphomas
T14, 18

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Q

BRAF

A

serine threonine kinase

melanoma, nonhodkins lymphoma

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Q

ckit

A

cytokine receptor

GI stromal tumor

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Q

cmyc

A

TF

burkitts lymphoma T(8,14)

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Q

HER2/ NEU

A

tyrosine kinase

breast, ovarian, gastric carcinomas

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Q

Lmyc

A

transcription factor

lung tumor

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Q

N myc

A

transcription factor

neuroblastoma

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Q

RAS

A

GTPase inhibited - permanent activated state

colon cancer, lung cancer, pancreatic cancer

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Q

RET

A

tyrosine kinase

MEN2A, 2B, medullary thyroid cancer

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Q

PDGFB

A

astrocytoma

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Q

cyclin D1

A

T 11,14 in mantle cell lymphoma

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Q

cdk4

A

amplified in melanoma

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