inflammation Flashcards
what molecules attract PMNs
LTB4 c5a IL8
what is the function of the other leukotrienes
LTC4, LTD4, LTE4 - slow reacting substances of anaphylaxis mediate vasoconstriction, bronchospasm, inc vasc perm.
what complement proteins activate mast cells
c3a, c5a
What are the opsonins
c3b and IgG
describe the function of kinin
cleaves high MW kininogen to bradykinin –> vasodilation and inc vasc permeability, pain
what molecules are responsible for pain
PGE2, bradykinin
what molecule is responsible for fever
PGE2
what are the antiinflammatory cytokines
IL10 , TGFB
When do macros come into the picture
peak 2-3 days
susceptibility in CGD
inc suscpetbility to staph aureus, pseudomonas, serratia, nocardia, aspergillus all catalase + organisms
people with MPO deficiency are at inc risk for what
candida infections
what is the second signal for CD4 T cell activation
B7 on APC binds CD28 on CD4 helper T cells
TH1 cells secrete
IFN - activates macros, B cell class switching igM –> igG, inhibits class TH2
TH2 cells secrete
IL4 - b cell class switching to igE IL5 - eosinophil chemotaxis and class switch to IgA IL13
what is the secondary signal for CD8 T cell activation
IL2 from cd4 TH1 cells
what are the signals for activation of a B cells
ag binding IgM or igD cd40 binds to CD40 L on helper T cell
digeorge syndrome
T cell deficiency hypocalemia - lack of parathyroid glands heart abnormalities vessel abnormalities
SCID is caused by many etiologies, but build up of what molecule is one major cause?
adenosine deaminase deficiency leads to inc adenosine and deoxyadenosine
what causes x linked agammaglobulinemia
mutated bruton tyrosine kinase - disordered B cell maturation
what are patients with x linked agammaglobulinemia suscpetible to
bacterial, enteroviruses, giardia need to avoid live vaccines
what is hyper igM syndrome
mutated cd40 L secondary signal for class switching doesnt occur low igA, igG, IgE - recurrent pyogenic infections
wiskott aldrich syndrome
thrombocytopenia, eczema, recurrent infections - defective cellular and humoral immunity bleeding is major cause of death
c1 inhibitor deficiency
hereditary angioedema
what does CREST stand for
calcinosis/ anticentromere antibodies raynauds esophageal dysmotility sclerodactyly telangiectasia
antibodies in mixed CT disease?
u1 ribonucleoprotein
What is a classic example of a “stable” cell type and what does this mean
liver tissue cells that are quiescent but can enter into S phase if needed
when does “repair “ occur
when regenerative stem cells are lost or cells lack regenerative capacity
scar formation consists of what process
type III collagen –> type I collagen - higher tensile strength
