Oncogenes Flashcards
From USMLE First Aid Page 221 in High-Yield Pathology Section
1
Q
Oncogenes
A
- Gain of Function leads to increased cancer risk.
- Need damage to only 1 allele.
2
Q
abl
A
- Associated with CML
- Gene Product: Tyrosine Kinase
3
Q
c-myc
A
- Associated with Burkitt’s Lymphoma
- Gene Product: Transcription Factor
4
Q
bcl-2
A
- Associated with Follicular and undifferentiated lymphomas - BCell Lymphomas (inhibits apoptosis)
- Gene Product: Anti-apoptotic Molecule
5
Q
HER2/neu (c-erbB2)
A
- Associated with Breast, Ovarian, and Gastric Carcinomas
- Gene Product: Tyrosine Kinase
6
Q
ras
A
- Associated with Colon Carcinoma
- Gene Product: GTPase that when activated, activates the MAP kinase pathway, leading to increased cell proliferation.
7
Q
L-myc
A
- Lung tumor
- Gene Product: Transcription Factor
8
Q
N-myc
A
- Neuroblastoma
- Gene Product: Transcription Factor
9
Q
ret
A
- Associated with Multiple Endocrine Neoplasia (MEN) types 2A and 2B
- Gene Product: Tyrosine Kinase
10
Q
c-kit
A
- Associated with Gastrointestinal Stromal Tumor (GIST)
- Gene Product: Cytokine Receptor
