Old Age Psychiatry Flashcards

1
Q

Define Delirium

A

Acute transient global organic disorder of CNS resulting in impaired consciousness and attention

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2
Q

There are three types of delirium. Describe Hypoactive Delirium

A

Lethargy
Reduced motor activity
Apathy
Sleepiness

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3
Q

There are three types of delirium. Describe Hyperactive Delirium

A

Agitated
Aggressive
Hallucinations and Delusions

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4
Q

What is the third type of Delirium?

A

Mixed - signs of both

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5
Q

There are many different causes of Delirium. Using the mnemonic THINk DELIRIUM, describe them

A

Trauma, Hypoxia, Increased age, NOF fracture, smoKer, Drugs, Environment, Lack of sleep, Imbalanced electrolytes, Retention, Infection, Uncontrolled Pain, Medical Conditions

hypoxia, hypoglycaemia, hyperglycaemia, infection, constipation, urinary retention, intoxication, withdrawl

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6
Q

Delirium is Acute in onset and fluctuating in course. Using the mnemonic DELIRIUM describe the classical presenting features

A

Disordered thinking, Euphoric, Language Impaired, Illusions (+/ - delusions or hallucinations), Reversal of sleep wake pattern, Inattention, Unaware (Disorientated), Memory Deficits

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7
Q

State the five ICD10 requirements for Delirium diagnosis

A
  • Impairment of consciousness and attention
  • Global disturbance in cognition
  • Psychomotor disturbance
  • Disturbance of sleep wake cycle
  • Emotional disturbance
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8
Q

Name five immediate investigations you would do for a Delirious patient

A
  • Nutritional and Hydration Status
  • Systems Examination
  • Urinalysis
  • Bloods - FBC, U&Es, LFTs, calcium, glucose, B12 folate ferritin
  • ECG
  • CXR
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9
Q

Describe the (10) features of an AMT (Abbreviated Mental Test)

A

Age, Time, (Recall 42 West Street at end), Year, Current Location, Identify two people, DOB, Date of WW1, Current Monarch, Count backwards from 20

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10
Q

Describe the features of CAM (Confusion Assessment Method)

A

Diagnosis involves the presence of 1 and 2 and 3/4

1) Acute Onset and Fluctuating Course
2) Inattention (demonstrated by serial 7s test)
3) Disorganised thinking (incoherent speech)
4) Altered consciousness

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11
Q

The mainstay of Delirium treatment is treating the underlying cause and providing reassurance. How can the patients environment be optimised?

A
  • Quiet
  • Well lit
  • Consistent staff
  • Encouraging visitation
  • Photos and familiar items
  • Orientate to time and place
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12
Q

How should the behaviour of Delirious patients be managed?

A

Medication should be a last resort

Oral low dose Haloperidol or Olanzepine
Avoid Benzodiazepines

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13
Q

Define Dementia

A

Generalised decline of memory, intellect and personality without impairment in consciousness leading to functional impairment

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14
Q

Name 4 irreversible causes of Dementia

A
  • Neurodegenerative
  • Infections (HIV, CJD)
  • Toxins
  • Vascular
  • Traumatic Head Injury
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15
Q

Name 4 reversible causes of Dementia

A

Visual/Hearing impairment,
Nutritional Deficiencies
Normal pressure hydrocephalus
Hypothyroidism

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16
Q

What is Vascular Dementia?

A

Occurs as a result of Cerebrovascular Disease (stroke, multiple infarcts, or chronic changes such as Atherosclerosis in the small vessels

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17
Q

What is Lewy Body Dementia?

A

Abnormal deposition of Lewy Body proteins throughout the neurones in the brainstem, substantia nigra and neocortex

If outside brainstem - more profound cholinergic loss
If within brainstem - more profound dopaminergic loss and Parkinsonian sx

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18
Q

What is Frontotemporal Dementia?

A

Atrophy of Frontotemporal Lobes

One type is Picks disease - where proteins tangle and are seen histologically (characterised histologically by Picks Proteins)

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19
Q

Dementia can be Cortical (such as Alzheimer’s and Frontotemporal). Give four clinical features.

A
  • Severe Memory Loss
  • Normal mood
  • Early Aphasia
  • Apraxia
  • Normal Coordination and motor speed
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20
Q

Dementia can be Sub-Cortical (such as DLB). Give four clinical features.

A
  • Moderate Memory Loss
  • Low mood
  • Impaired Coordination
  • Slow Motor Speed
  • May have Dysarthria
21
Q

Give an example of mixed Cortical and Subcortical Dementia

A

Vascular

22
Q

Describe the genetic risks for developing Alzheimer’s

A

Early Onset - Presenilin 1 and 2, Amyloid Precursor Protein
Late Onset - ApoE 4

23
Q

what are some risk factors for alzheimer’s disease?

A

advancing age

family hx

genetics

down’s syndrome

low IQ

cerebrovascular disease

vascular risk factors

24
Q

Describe the ICD10 criteria A-D for Dementia

A

A - evidence of decline in memory and other cognitive abilities
B - Preserved awareness for long enough to demonstrate A
C - Decline in emotional control/motivation/behaviour (emotional lability, irritability, apathy, coarsening social behaviour)
D - A must be present for 6 months

25
Q

What are the parameters for Presenile and Senile Dementia?

A

Presenile is <65
Senile is >65

26
Q

Describe the features of early Alzheimer’s

A

Memory lapses
Difficulty finding words
Forgetting names of people/places

27
Q

Describe the late stages of Alzheimer’s

A

Disorientation to time and place
Apathy
Incontinence
Agitation

28
Q

Describe the ICD10 criteria for early onset Alzheimer’s

A

A - General criteria for Alzheimer’s met and age <65
B - Atleast one of: relatively rapid onset and progression, aphasia/agraphia/apraxia/alexia

29
Q

Describe the ICD10 criteria for late onset Alzheimer’s

A

A - General Alzheimer’s criteria met and age >65
B - Atleast one of: Slow gradual onset and progression, predominance of memory impairment over intellectual ability

30
Q

How does Vascular Dementia typically present?

A
  • Late sixties/early seventies
  • Stepwise deterioration
  • Confusion
  • Memory loss
  • Early personality changes and Emotional
  • May have signs of cardiovascular disease
  • may have UMN signs
31
Q

What is Mixed Dementia?

A

Features of both Alzheimer’s and Vascular

32
Q

Name four features of DLB

A
  • Day to day fluctuations in cognitive performance
  • Recurrent visual hallucinations
  • Motor signs of Parkinsonism
  • Recurrent falls, syncope, depression
  • Severe sensitivity to Neuroleptic drugs
33
Q

Describe four clinical features of Frontotemporal Dementia

A
  • Usually 50-60 y/o
  • Worsening of social behaviour
  • Early personality changes such as disinhibition/apathy/restlessness
  • Memory is preserved in early stages
34
Q

How does Huntington’s Disease present?

A
  • Abnormal Choreiform Movements of face hands and shoulders and gait abnormalities
  • Dementia Symptoms presenting later on

Autosomal dominant so strong FH

35
Q

What is the triad of Normal Pressure Hydrocephalus

A

Dementia with frontal lobe disturbance
Urinary Incontinence
Gait disturbance (wide)

average age of onset after 70

36
Q

Describe three features of Creutzfield Jakob Disease

A
  • Onset usually <65
  • Rapid progression and death within 2y
  • Disintegration of all higher cerebral functions
  • Dementia associated with neurological signs
37
Q

How is suspected dementia investigated?

A

Initially referred to memory clinic
Routine panels of bloods- FBC, CRP, U&Es, calcium, LFTs, glucose, vit B12, folate, TFTs

38
Q

what other non-routine investigations may be done if clinically indicated for dementia?

A
  • urine dip to rule out UTI
  • CXR
  • syphilis serology and HIV testing
  • brain imaging - CT, MRI, SPECT
  • ECG
  • EEG
  • LP
  • genetic tests
  • cognitive assessment
39
Q

What imaging is used to differentiate Alzheimer’s, Vascular and Frontotemporal?

A

SPECT - Single Photon Emission Computed Tomography

40
Q

what is always important to assess in dementia patients?

A

functional status - dressing, continence, self-care, shopping/housework, ability to mange financial affairs, social contacts, safety in the home, ability to cook, nutrition

41
Q

Name four features of the MMSE

A

Orientation
Concentration (Serial 7s)
Memory - short term, long term, recent
Grasp - name of monarch

Normal is 25-30, severe is less than 10

42
Q

Name three frontal lobe tests

A

Verbal fluency and initiation
Clock drawing tests
Similarities (why are two objects similar?)

43
Q

State two general managements of Dementia

A
  • Inform DVLA
  • Advanced planning
  • later stages - Mental Capacity Act 2005 needs to be adhered to
44
Q

Describe the non pharmacological management of Dementia

A
  • Social Support
  • Community dementia teams
  • Information and education
  • Aromatherapy, massage, animal-assisted therapy
  • Assistance in day to day activities
45
Q

One of the pharmacological options to treat Dementia is acetylcholinesterase inhibitors. Given an example, 2 contraindications and 2 side effects

A

Donepazil, Galantamine and Rivastigmine

CI - Renal impairment, Hepatic impairment

SE - GI disturbance, Bradycardia, muscle spasms

46
Q

What is the action of Memantine?

A

NMDA receptor antagonist

used for AD when moderate when intolerant/contraindicated to use AChEi or in severe AD

47
Q

How could you manage challenging behaviour of Dementia patients?

A

Short course of antipsychotics

antidepressants for low mood

Caution in DLB - Neuroleptic Malignant Syndrome

48
Q

principals of dementia management

A
49
Q

dementia v delirium

A