OG Flashcards
1
Q
Who should receive a 2 week wait OGD referral?
A
Dysphagia
Weight loss with reflux/abdo pain/dyspepsia
Upper abdominal mass
2
Q
How many biopsies for suspicious mucosal lesions at OGD?
A
6-8
3
Q
What is the characteristic finding in achalasia
A
Loss of ganglion cells in Auerbachs plexus
4
Q
What is the classification of Peptic Ulcers
A
Modified Johnson
1. body of stomach (not associated with acid hyper secretion) (50%)
2. Body in combination with duodenal ulcers (acid ++) (25%)
3. Pyloric channel within 3cm of pylorus (acid ++) (20%)
4. Proximal GOJ <10%)
5. Chronic NSAID use
5
Q
What are the characteristics of Gastric lymphoma?
A
5% of gastric malignancies - mostly B cell lymphomas
May regress with H Pylori eradication
More commonly are metastatic
6
Q
What is Plummer Vinson syndrome?
A
Oesophageal web with Iron deficiency –> dysphagia
7
Q
What is the most common site of benign gastric ulcer?
A
Lesser curve (50%)
8
Q
Dilation of oesophageal cancer carries what risk of perforation?
A
4-6%
9
Q
What are the characteristic histological findings of Schatzki rings?
A
They are typically found at the OG junction, with oesophageal mucosa above and columns epithelium below
10
Q
What lymph nodes are removed in a D1 gastric resection?
A
Stations 1-7
Lesser/Greater curve + Left gastric
11
Q
What lymph nodes are removed at a D2 gastric resection?
A
D1 stations (1-7) + 8-12
8 - Common hepatic
9 - Coeliac
10 - Splenic hilum
11 - Spenlic artery
12 - Hepatoduodenal ligament
12
Q
What lymph nodes are removed at a D3 gastric resection?
A
D1 (1-7) + D2 (8-12) + 14-15
14 -root of SMA
15 - middle colic
(nb - not 13, posterior to pancreatic head)
13
Q
What comprises a D4 gastric resection?
A
D1 (1-7) + D2 (8-12) + D3 (14-15) + 16
16- Para-aortic nodes
14
Q
How are BMI categories altered in asian patients?
A
reduced by 2.5
15
Q
What are the weight loss service tiers in the NHS?
A
Tier 1 - community based
Tier 2 - Advice from GP and medication (Orlistat, Mysimba [naltrexone/burprenorphine], Saxenda [liraglutide]
Tier 3 - Specialist weight management (MDT)
Tier 4 - Bariatric surgery
16
Q
What are the NICE criteria for bariatric surgery?
A
1) BMI≥40 or 35-40 with significant disease (T2DM/HTN)
2) All appropriate measures undertaken and failed
3) Intensive Tier 3 management available (completed with weight loss ≥5%)
4) Patient generally fit for anaesthesia
5) Person commits for need to follow up
17
Q
How wide is stomach typically left behind after a sleeve gastrectomy?
A
About 4cm
18
Q
How long are the biliarypancreatico and ailmentary limbs typically made in a gastric bypass (for weight loss)?
A
BP 50cm
Ailmentary 100cm
19
Q
Which bariatric surgery procedure has the greatest long term weight loss?
A
Total At 10 years:
Bypass 25%
Sleeve 17%
Band 14%
Excess body weight loss At 5 years:
Bypass 63%
Sleeve 53%
Band 48%
20
Q
What follow up do patients undergoing bariatric surgery require?
A
For all - nutrition and CNS for 1 year
For bands - inflation increments
For sleeves and bypass - micronutrients, with regular monitoring of FBC, U&E, LFT, Folic acid, Ca, PTH, Vitamin D, Lipids, B1, B12, Vitamin A,EK
21
Q
What advice is given re pregnancy after bariatric surgery?
A
Avoid for 12 months due to risk of foetal malnutrition
22
Q
What late complications are typically associated with a gastric band (5)?
A
1) Port / tubing issues-Port replacement or shortening of tube
2) Oesophagitis-OGD +/-deflation or removal
3) Slippage-AXR +/-water soluble contrast- repositioning or removal
4) Gastric pouch-Water soluble contrast swallow/ OGD-Deflation +/-gradual refilling or removal
5) Erosion-Removal
23
Q
What late complications are typically associated with a sleeve gastrectomy?
A
Reflux oesophagitis-OGD- PPI +/- convert to Roux en Y
Stricture- Endoscopic dilatation
Twist/ kink- convert to Roux en Y
24
Q
What late complications are typically associated with a gastric bypass?
A
Marginal ulcer-Smoking cessation, avoid NSAIDS, PPI, consider anastomosis revision
Anastomotic stricture-Endoscopic dilatation
Internal hernia-Laparoscopy and reduction of hernia, closure of spaces
25
In what proportion of cases of mid 1/3 SCC will cervical lymph nodes be positive?
17%
26
Where are lymph node metastases most frequently seen in oesophageal adenocarcinomas?
Left gastric (17) - 24% and paraesophaeal stations (8M/8L) - 18%
27
What is the lymph node metastasis rate for T1a oesophageal cancer?
M1 - epithelial layer 0%
M2 - invasion of lamina propria 0%
M3 SCC - Invasion of muscularis mucosae 0-8%
M3 AC - Invasion of muscularis mucosae 1.8-4.5%
Overall SCC 0-3%
Overall AC 1.3-2%
28
What is the lymph node metastasis rate for T1b Oesophageal cancer?
Through muscularis mucosae:
SCC
SM1 (superficial 1/3) 8-33%
SM2 (middle 1/3) 17-30%
SM3 (Deep 1/3) 36-69%
Overall 26-50%
AC
SM1 (superficial 1/3) 0-22%
SM2 (middle 1/3) 0-35%
SM3 (Deep 1/3) 26-78%
Overall 22-41%
29
What is the most frequently occurring benign oesophageal tumour?
Leiomyoma (75%)
Others such as fibromas, neuromuscular tumour and NETS are very rare
30
How do oesophageal leiomyomas tend to present?
Incidental finding on OGD. Tend to have more symptoms >5cm, dysphagia and reflux
31
Where do oesophageal leiomyomas most frequently occur?
Distal 2/3 of oesophagus, 5% multiple
32
What is the most useful investigation for Leiomyoma of the oeosophagus?
EUS - typical appearance with no invasion of muscularis layer. Biopsies are often non-diagnostic and can disrupt tissue planes prior to resection
33
What is the histological findings of a leiomyoma?
Bundles of interlacing smooth muscle cells,
well-demarcated by adjacent tissue or by a definitive capsule
Tumour cells have blunt ended elongated nuclei with minimal atypic and few mitotic figures
34
What is the optimum treatment of oesophageal leiomyomas?
<5cm surveillance
>5cm or symptomatic - can be approach left or right thorax, muscle layer split and lesion enucleated
35
What is Menetriers disease?
Rare form of acquired gastropathy
Characteristic - foveolar hyperplasia + absent oxyntic glands
Giant rugal folds >1cm persisting after insufflation
Antral sparing
Diagnosed on deep biopsies (pit to gland ratios)
Risk of malignancy of 10% at 1 year
36
What is the most common origin cell of a gastric lymphoma?
Metastatic non gastric primary
37
For primary gastric lymphoma, which is the most common cell type?
B cell lymphomas
38
How frequent is reflux disease in Western populations?
20%
39
What are the characteristics of a normal lower oesophageal sphincter?
3-4cm with pressure of 10-25mmHg
40
What drug characteristically enhances contraction of the LOS?
Metoclopramide vagally mediated
41
What factors may relax the LOS
Alcohol, smoking and caffeine
42
In early GORD, which is the most common pathological mechanism of reflux?
Increased transient post prandial LOS relaxations (rather than fall in LOS pressure).
In late GORD, the LOS pressure reduces (?repeated acid exposure), exacerbated by decreased intra-abdominal sphincter length (obesity) and crural weakness and HH
43
How is a reflux episode defined during pH monitoring?
When pH<4
44
What factors are measured in pH monitoring (6)?
Number of reflux episodes (pH<4) - Normal <50
%total time<4 (<5%)
%upright time<4 (<8%)
%supine time<4 (<3%)
Number episodes >5 minutes (<3)
Longest reflux time
Demeester score >14.7 considered pathological
Most useful is total reflux time and symptom correlation
45
What types of wrap are used with a fundoplication?
Nissen - posterior 360
Toupet - posterior 270
Dor - anterior 180
Watson - anterior 120
46
What are the grades of varices?
Grade 1 - varices the collapse to air insufflation
Grade 2 - varices between 1 and 3
Grade 3 - varices large enough to occlude lumen
47
What primary prophylaxis for bleeding is required for Grade 2 varices
Non-selective beta blocker - e.g. Propranolol or nadolol.
Band ligation only for rebreeding. Repeat 7-14days until gone
48
What are the types of gastritis (5)?
Type A - autoimmune (antral sparing, parietal cell antibodies, hypochlorhydria, loss of IF and B12, elevated gastrin levels)
Type B - antral (H.pylori)
Reflux - bile reflux (chronic inflammation, foveolar hyperplasia --> Prokinetics)
Erosive - NSAIDS(/etoh, COX1)
Stress - diffuse ulceration following hypotension (most sensitive GIT)
(Menetriers disease - gross hypertrophy, premalignant)
49
In what percentage of patients with gastric ulceration is H.pylori implicated?
60%
50
What are the characteristics of H.pylori organism?
Gram negative helical rod
Microaerophillic
Produces urease enzyme (hydrolyses urea --> NH3)
NH3 affects astral G cells --> release of gastrin
Cannot colonise native duodenal mucosa, but can induce metaplasia then colonise and inflame.
51
What is the risk of peptic ulcer in patient with H.pylori?
10-20% (1-2% risk of gastric cancer , <1% MALT lymphoma)
Decreased risk of Oesophageal adenocarcinoma
52
What are the testing strategies for H.pylori (5)?
1) C13/C14 breath tests - diagnosis/confirmation of eradication (cannot be used if Abx <4 weeks)
2) Blood IgG - initial diagnosis only
3) Rapid urease testing (Clo) diagnosis and confirm eradication - 80-95% sens, 90-100% spec
4) Histology (gold standard, resource intensive)
5) Culture (gold standard, resource intensive, difficult)
6) Stool antigen test
53
What is the characteristic change seen with Barrett's oesophagus?
Metaplastic change from stratified squamous to columnar gastric epithelium.
Three types - intestinal (high risk), cardiac and fundal
54
How can Barrett's be subdivided?
Long >3cm and short segment <3cm
55
What is the recommended initial treatment of oeosophagitis (if severe)?
Full dose (e.g. 40mg oemp/esomep) for 8 weeks - if fails switch or go high dose
56
How long after PPIs will a h.pylori stool or breath test be accurate?
2 weeks
57
What is the upper oesophageal sphincter comprised of?
Cricopharyngeus and proximal oesophageal musculature
58
What are the 4 types of hiatus hernia?
1 sliding (95%)
2 paraoesophageal
3 mixed
4 giant
59
What is the evidence for LARS?
LOTUS trial 2011 JAMA - less reflux symptoms but more dysphagia, bloating flatulence
REFLUX trial 2013 BMJ - Better QoL, less anti reflux meds,
Rickenbacker Meta-analysis - less symptoms, better QoL, but significant still on antacids
Watsons group
- 20 year follow up - no benefit to short gastric division
- Nissen probably has less reflux but more side effects than anterior wraps
- No benefit to prophylactic mesh
60
What are the characteristic physiological findings of Achalasia?
1) Absence of swallow-induced relaxation of the LOS
2) Absence of peristalsis along oesophageal body
61
What is the investigation of choice for Achalsia?
High resolution manometry (>normal resolution)
Intraluminal circumferential pressures at 1cm over 26cm
62
What is the most diagnostic measurement for Achalasia?
HRM - Supine integrated relaxation pressure (IRP) >15mmHg
SIRP - mean of 4s of maximal relaxation at beginning of UES relaxation, referenced to gastric pressure
63
What Types of achalsia are there?
Chicago Classification
Type 1 - Abnormal median IRP, 100% failed peristalsis
Type 2 - Abnormal median IRP, 100% failed peristalsis, ≥20% swallows with pan oesophageal peristalsis
Type 3 - Abnormal median IRP ≥20% swallows with presmature/spastic contraction + no evidence of peristalsis
Type 1 Classic
Type 2 Achalasia with oesophageal compression
Type 3 Spastic
64
Which type of achalsia has the most favourable prognosis?
Type 2 >Type 1 >Type 3
65
What scoring system is used for Achalasia symptoms?
Eckardt score
Good outcome if ≤3, poor ≥3.
Composite of dysphagia, regurgitation, chest pain and weight loss
66
What is the 5 year success rate of Pneumatic Dilatation for achalasia?
90% 1 year, 86% 2 years, 82% 5 years, 50% 10 years
25-33% need repeat within 5 years
Graded PD using 30-->35-->40 balloons
Risk of perforation of about 5%
67
What evidence for POEM vs Heller vs PD
Ponds 2019 JAMA - 2 year treatment success 92% POEM 54% PD
Werner 2019 NEJM - 2 year treatment success equivalent POEM/Heller+Dor
Higher reflux POEM, Higher complications Heller
68
What is the treatment failure rate of LHM in different types of Achalasia?
Type 1 14.6%
Type 2 4.7%
Type 3 30.4%
69
What length of myotomy should be performed for a LHM
8cm - 6cm proximal to GOJ and 2-3cm distal
70
What is the risk of SCC in patients with Achalsia?
Increased 10-50 times
71
What are the differences between Idiopathic achalasia and Chagas disease?
In Chagas disease both excitatory and inhibitory neurones are lost (cf IA - inhibitory only) and the LES pressure is variable
72
What is the Los Angeles Classification for oesophagitis? (4)
A - one fold <5mm
B - one fold >5mm
C - multiple folds <75% circumference
D - multiple folds >75% circumference
73
What is the Prague Criteria for Barrett's oesophagus?
C/M extent + Islands
74
What is the Paris Criteria for oesophageal lesions?
Descriptive of anatomical appearance I-III
I raised
2 flat
3 excavated
75
What is the increased risk of OAC in patients with Barretts?
OR of 11.3, 0.33% annual incidence in non-dysplastic
76
What surveillance should patients with Barrett's oesophagus undergo?
BSG guidelines
Non-dysplastic
<3cm - 3-5 years
≥3cm 2-3years
Quadrantic biopsies every 2cm (Seattle protocol every 1cm is no better)
Dysplastic (2 GI Pathologists)
Indefinite - repeat 6 months with maximal acid suppression
LGD - repeat 6 months, if confirmed probably should have RFA (42% HGD at 4 years)
HGD - ESD>EMR/RFA (40% risk of adenocarcinoma)
EUS often unhelpful
77
What medical treatment should patients with Barrett's oesophagus receive?
High dose PPI (80mg esomeprazole)
?Aspirin
ASPECT trial 2018 says better for high dose PPI than low dose in preventing composite of HGD, OAC and death.
?Aspirin
78
What is are the points of FB impaction in the oesophagus
1) Hypopharynx (cricopharynxgeus)
2) Upper thoracic oesophagus (Aortic arch, low pressure zone at transition between striated and smooth muscle fibres)
3) LOS
79
In what proportion of patients with impacted oesophageal foreign bodies it there an underlying structural abnormality?
25% - stricture, HH, web, Schatzki ring, eosinophilic oesophagitis, achalasia, tumours
80
What is the characteristic finding seen after ingestion of Ammonia?
Superficial haemorrhagic gastritis evolving over 24-48 hours
NB airway burns from vapour
81
What is the best diagnostic test for transmural necrosis after caustic ingestion?
Contrast CT at 3-6 hours > OGD - WSES guidelines
Looking for absence of post-contrast wall enhancement
82
What classification systems for caustic ingestion exist?
CT
Grade 1 - homogenous enhancement of wall without oedema/fat stranding
Grade 2a - enhancement of oesophageal mucosa with oedema and enhancement of outer wall --> target
Grade 2b - no enhancement of mucosa (necrotic)
Grade 3 - no post contrast wall enhancement
Zargar's Endoscopic
Grade 0 - normal
Grade 1 - superficial mucosal oedema and erythema
Grade 2 - mucosal ulceration (2a superficial, 2b deep)
Grade 3 - transmural ulceration with necrosis (3a Focal, 3b Extensive)
Grade 4 - perforation
83
What is the optimum management of Caustic ingestion?
Type 1 -2 (CT) --> NOM
If deterioration, repeat CT
Grade 1 - discharge 24-48 hours no follow up
Grade 2a - <20% risk of strictures
Grade 2b - >80% risk of strictures
84
What is the lifetime risk of oesophageal Adenocarcinoma after caustic ingestion?
7%
85
What is the most common cause of oesophageal perforation?
Iatrogenic - diltation, VBL, sclerotherapy - mostly in hypopharynx (60%)
Boerhaave (15%) lower 1/3 usually on Left border, large defect
Rare - trauma, malignancy, FB, caustics
10-20% mortality
86
What scoring systems can be used to help predict success of NOM in oesophageal perforation
Altorjay criteria
Early, well, contained, no esophageal disease, close observation possible
Pittsburgh classification
Well, young patients, with contained leak, early presentation and no cancer
87
When is surgery ideally performed for oesophageal perforation (if necessary)
within 24 hours - mortality 10% vs 30% after
88
How is a thoracic oesophageal perforation repaired?
Thoracotomy
Two layer repair with suturing of mucosa and muscularis (25-50% failure rate)
Buttress if possible +/- T-tube
Need to extend muscular incision as mucosal injury will be greater
Feeding jejunostomy + gastric decompression
89
What percentage of GOJ cancer have peritoneal metastases?
Up to 15%
90
In what circumstances can a T1b AC of the esophagus be managed by ESD?
ESMO guidelines 2016
SM1 - <500um invasion, L0,V0, G1/2, <20mm diameter)
91
Which trials are investigating the treatment of presurgery complete responders to CRT in AC oesophagus?
ESOstrate and SANO
92
What is the Siewert staging system for GOJ tumours?
Siewert 1 - Tumour epicentre 1-5cm above anatomic GOJ
Siewert 2 - Tumour epicentre 1cm above to 2cm below anatomic GOJ
Siewert 3 - Tumour epicentre 2-5cm below GOJ - treat as gastric
93
What is the RCT evidence for a minimally invasive approach to oesophagectomy?
TIME Trial (2012 Lancet) – open vs MIO (56 vs 59) – Pulmonary infection RR 0.30
MIRO Trial (2019 NEJM) – open vs hybrid (104 vs 103) – major complications OR 0.31, pulmonary 18 vs 30%. Survival not different QOL better up to 2 years post-surgery (when most patients die)
ROMIO trial awaited
94
What is the most common type of gastric polyp?
Fundic gastric polyps
Usually <0.5cm, commonly associated with HP
Small malignancy risk, polypectomy if >1cm
Can be associated with polyposis syndromes if multiple
95
What is the risk of malignancy in 1 2cm gastric adenomatous polyp?
50%
Often associated with chronic gastric metaplasia
96
What are the BSG guidelines for gastric polyps?
• Sample all types
• Biopsy of intervening mucosa
• Eradicate H.Pylori
• Remove if dysplastic, adenomatous or symptomatic
• Repeat gastroscopy at 1 year if dysplastic and not removed or high risk
97
What is the probability of stricture formation when EMR >50% circumference
2/3
98
How frequently is Barretts seen on OGD for reflux symptoms?
15-20%
99
Which radioactive material is typically used for brachytherapy of the oesophagus?
Iridium -192
100
Where are pulsion diverticulae most common in the oesophagus?
distal oesophagus, right posterolateral wall
101
What is chronic afferent loop syndrome?
Abdominal pain after eating where an afferent (BP) loop is compressed for mechanical reasons and progressively enlarges causing pain.
Relieved by vomiting, which will be bile
102
What interventional procedure at OGD has the highest risk of perforation?
Stent placement 5-25%
103
What proportion of patients with systemic sclerosis have oesophageal involvement?
Systemic sclerosis - skin thickening, skin oedema, with 80% oesophageal involvement
Smooth muscle atrophy at LOS
104
What are the manometric findings of Nutcracker Oesophagus?
High amplitude contractions with normal peristalsis
105
What tests should be sent if a chylothorax is suspected?
Presence of chylomicrons
TG>110mg/dL
Cholesterol<200mg/dL
Fluid to serum cholesterol ratio <1 and TG ratio>1
106
When might an endoscopic approach be appropriate for gastric cancers?
JGCA
- T1a non ulcerated, differentiated <2cm - EMR/ESD
- T1a with ulceration <3cm - ESD
107
Where is the pH electrode placed?
5cm above manometrically determined upper border of LOS
108
What is the most common soft tissue sarcoma?
A GIST
109
What are the most common mutations associated with GISTs?
KIT or PDGFRA,
More rarely NF1 and BRAF
NB
Carney Triad syndrome (gastric GIST, paraganlgioma, pulmonary chondroma)
Carney-Stratakis syndrome
Type 1 NF
Familial GIST
110
What is the standard management of GISTs <2cm
Serial imaging - without biopsy
For larger tumours an EUS guided biopsy for diagnosis is helpful, small risk of seeding
111
What diagnostic stains are useful for GISTs?
only 1% are immunonegative for CD117 and DOG1
If doubt, molecular analysis for KIT1/PDGFRA
112
What are proven prognostic factors for GISTs?
Mitotic rate
Tumour size
Tumour site (Gastric>Rectal/SB)
Presence/absence of rupture
Combined in modified NIH classification - v.low, low, intermediate, high risk
113
For localised GIST, when should Imatinib be given?
Neoadjuvant If immediate primary resection is difficult or morbid
Adjuvant for 3 years if high risk
114
What is the treatment of metastatic/recurrent GIST?
Imatinib --> Sunitinib --> Regorafenib
Exon 11 normal
Exon 9 - double dose imatinib
Exon 17 - regorafenib
115
What is the risk of lymph node positivity according to T stage in oesophageal cancer?
T1a - 0-3%
T1b - 25%
T2 - 50%
T3 - 80%
T4 - 100%
116
What are the Lauren types of gastric adenocarcinoma and which has the best prognosis?
Intestinal and Diffuse - Intestinal better prognosis (20% vs 10% at 5 years)
Intestinal has M:F of 2:1 (Diffuse equal) and higher age of detection (55 vs 45)
117
In which Lauren type of Gastric Adenocarcinoma are signet cells seen?
Diffuse type
Due to prominent mucin production within storm and outside glands.
118
In which cells are the problem in Pernicious anaemia?
The parietal cells failing to produce sufficient IF (gastric antrum)
119
What is the lymph node metastasis rate for T1b oesophageal tumours?
sm1 = 6% AC 27% SCC
sm2 = 23% AC 36% SCC
sm3 = 58% AC 55% SCC
120
What is the normal stomach pH?
About 2
121
Where is gastric acid produced?
Oxyntic glands of Parietal cells of stomach, maintained by H/K ATPase
122
In which phase is most gastric acid secreted?
Cephalic phase (smell/taste) --> vagal stimulation of gastrin and acid (30%)
Gastric phase (distension) --> low H+/peptides and gastrin release (60%)
Intestinal phase (food in duodenum) --> high acid/distension/hypertonic in duodenum inhibits gastric acid secretion (10%)
123
What factors increase gastric acid secretion (3)?
Vagal nerve stimulation
Gastrin release
Histamine release from enterochromaffin like cells
124
What hormones decrease gastric acid production? (3)
Somatostatin (via decreased histamine)
Cholecystokinin
Secretin
125
Where is gastrin produced?
G cells in antrum of stomach
126
What are the effects of gastrin release?
Increase HCl, pepsinogen and IF secretion
Increases gastric motility
127
Where is CCK produced?
I cells in upper SI, released in response to partially digested proteins and TGs
128
What are the effects of CCK?
Promotes digestion
-Pancreatic enzyme release (exocrine/endocrine)
-Contraction of GB and SOD relaxation
-DECREASED gastric emptying
129
Where is secretin released?
S cells in SI
in response to acidic chyme and FAs
130
What are the effects of secretin?
Counteracts acidity
-Increases exocrine pancreatic secretion
-inhibits acid/pepsinogen secretion
131
What are the effects of VIP?
Digestion
-Stimulates secretion by pancreas/intestines
-inhibits acid/pepsinogen
132
Where is Somatostatin produced?
D cells in pancreas and stomach
133
What are the effects of somatostatin?
Decreases acid/pepsin/gastrin
Decreases pancreatic enzyme secretion
Decreases insulin and glucagon
Inhibits trophic effects of gastrin
STIMULATES gastric mucous production
134
Where is gastric inhibitory peptide secreted?
K cells of duodenum an jejunum
in response to FAs and glucose
135
What are the effects of GIP?
Mostly increased insulin release
Small decrease in gastric acid release
136
What effect dose vagal stimulation have on gastric emptying?
Increases it (nb vagotomy --> pyloroplasty)
137
Which hormones increase (1) and decrease (3) gastric emptying?
Increase - gastrin
Decrase - GIP, CCK, Enteroglucagon
138
Which type of gastrojejunostomy empties most effectively?
Posterior retrocolic
139
What is Hereditary Diffuse gastric cancer?
CDH 1 mutation
Average age diagnosis of 38
Associated with lobular Brest cancers and cleft lip
60-70% risk of cancer
140
What bacteria are involved in cholecystitis?
Primarily chemical, but secondary infections from gut
-E.Coli, Kelbsiella and Step Faecalis (aerobic)
-Bacteroides fragilis, clostridia (anaerobic)
Often mixed
141
What is the muscular composition of the oesophagus?
Overall - external longitudinal, inner circular
For external
Top 1/3 - voluntary striated
Middle 1/3 - striated and smooth
Bottom 1/3 - smooth muscle
142
How many sequential oesophageal dilatation should be attempted in 1 sitting?
No more than 3
143
When should fluoroscopic guidance be used for oesophageal stricture dilatation?
High risk
- post radiation/caustic
- impassable endoscopically
- long, angulated or multiple
144
When should contrast studies be performed after oesophageal dilatation?
Not routinely, only if chest pain, fever, breathlessness or tachycardia
145
How frequently should dilatation be performed for stricture?
Weekly or bi-weekly until ≥15mm dilator placed
146
What size of pneumatic balloon should be used in achalasia?
30mm, with build up to 35 and 40mm
147
What are typical indications for oesophageal dilatation?
Achalsia
Post-radiation
Caustic ingestion
Post-operative/post-endoscopic
Eosinophilic oesophagitis
Schatzki's ring (if symptomatic)
Peptic strictures
148
Where do Dieulafoy's lesions most commonly occur?
In the stomach submucosa - large tortuous arteriole
149
When should the urea 13c breath test and helicobacter stools antigen tests not be performed?
Within 2 weeks of PPI
Within 4 weeks of antibacterial treatment
150
What is the triple therapy for H.Pylori?
No allergy:
1st line PPI + Amox + Clari or metronidazole (7/7)
2nd linePPI + Amox + metronidazole or Clari (other choice) (7/7)
3rd line - PPI + Bismuth subsalicylate + 2 x antibiotics or rifabutin
Pen allergy:
1st PPI + Clari + Metro (7/7)
2nd PPI + Metro + levo
151
In which patients should an open approach to repair of peptic ulcer be adopted?
Unstable, severe CV comorbidity, especially if old
152
What factors contribute to the prevention of GORD (6)?
1) Crura
2) Oblique Angle of GOJ
3) Apposition of mucosal folds
4) Phreno-oesophageal ligament
5) Intra-abdominal pressure compressing intra-abdominal oesophagus
6) High pressure zone of LOS
153
Where is gastric cancer most common in the West?
Proximally (distally in East)
154
Which blood group has an increased incidence of gastric cancer?
A
155
What influence do KIT and DOG positivity have on prognosis for GIST?
None
156
When is a PET CT not useful for OG cancers?
-Obvious metastatic disease
-T1a Oesophageal cancer
-Gastric cancer unless suspecting occult metastatic disease
157
When should patients with a BMI of 30-35 be referred for consideration for bariatric surgery?
Recent diagnosis of T2DM
158
What length of Roux Limbs should be used for a cancer reconstruction?
50cm BP
50cm Alimentary
159
What conditions produce foveolar hyperplasia?
Reflux gastritis (resection or cholecystectomy)
NSAIDS
Alcohol
160
What is Gurvits syndrome?
Acute oesophageal necrosis.
M:F in 6th decade, DKA
161
What is the most common type of gastric polyp?
Fundic (75%) - may be more common in patients on acid suppression
162
What are some risk factors for gastric cancer?
STK11 (Peutz Jaegers)
Helicobacter
EBV
Smoking
Low fibre diet
CDH-1 (1-3% of cancers, 60-70% risk)
163
What is Jackhammer oesophagus?
A specific type of Nutcracker oesophagus (hyper contractile) - with a distal contractile interval of >8000
164
What conditions are associated with eosinophilic oesophagitis?
Asthma, coeliac disease
Get trachealisation or concentric rings with white plaques in oesophagus
165
How should post ERCP bleeding be treated?
Re-ERCP and treatment
166
What is the most common site of a peptic ulcer?
Duodenum 2 -3x more than stomach
167
Where is the primary site of intestinal sodium reabsorption?
Jejunum
168
What are the regions of the mediastinum?
Superior
Inferior - posterior/anterior/middle
169
What are the contents of the superior mediastinum?
Arteries (4)
-Arch of aorta
-right brachiochephalic
-left subclavian
-left common carotid arteries
Veins (3)
-SVC
-right brachiocephalic
-left braciocephalic
Organs (3)
-Oesophagus
-Trachea
-Thymus
Nerves (3)
-Left recurrent laryngeal
-Phrenic
-Vagus
Other
-Thoracic duct
170
What are the contents of the anterior mediastinum?
Fat + LN + thymus
171
What are the contents of the middle mediastinum?
-Pericardium
-Heart
-Aortic root
-Arch of azygos vein
-Main bronchi
172
What are the contents of the posterior mediastinum
Oesophagus
Aorta
Azygos vein
Thoracic duct
Vagus nerve
Sympathetic nerve trunks
Splanchnic nerves
173
How is the thoracic duct related to the oeosphagus?
Mostly posterior - passes to left at T5
174
What is a specific contraindication for sleeve gastrectomy?
Barretts
175
What vitamin deficiencies can be seen post bypass?
Vitamin B3/12/1
Vitamin D
176
What is Wernickes triad?
Thiamine
Ophthalmoplegia, cerebellar dysfunction, confusion
177
What is the most important vitamin deficiency post bariatric surgery?
Thiamine - short half life of body stores 9-18 days
178
Which nerves are divided in a highly selective vagotomy?
Nerves of Laterjet
179
How many segments does each lung contain?
10
180
How many lobes are in each lung?
Right - 3 (oblique/transverse fissures)
Left - 2 (lingual)
181
How should patients with small GISTS be treated?
If <2cm, surveillance with annual EUS (BSG 2017)
182
How should patients with NSAID associated ulcers and H.pylori be treated?
2 months of PPI, stop NSAID, then first line eradication regime
183
How long after decontamination should gastroscopes be used?
Within 3 hours
184
What factor would suggest that GISTS are completely insensitive to TKIs?
c-KIT wild type
185
What treatment is given for KIT exon 17 GISTS?
Regorafenib
186
What treatment is given for KIT exon 9 GISTS?
Imatinib - may benefit given dose escalation as well
187
What is the minimum examination time for Barretts screening?
7 minutes
188
How long should patients be observed post dilatation?
2 hours
189
What medication can reduce the risk of stricturing after large EMRs?
Oral prednisone
190
What is the incidence of H.Pylori in perforated duodenal ulcer?
90-95% so treat empirically
191
What histo stain would be more consistent with carcinoma than lymphoma?
Pancytokeratin
192
from where does the right gastric artery arise?
Proper hepatic (53%)
Common hepatic (20%)
193
What is the size of the gastric pouch in bariatric procedures?
Band/Bypass - 20ml
Sleeve 150-200ml
194
What are the diagnostic criteria for chylothorax?
Triglyceride >110mg/dl
Cholesterol <200mg/dL
Presence of chylomicrons
Use medium chain fatty acids
195
Why should surgery be offered for the treatment of morbid obesity?
- Global epidemic with cost to NHS of >£5billion/year
- Reduced life expectancy of patients due to CVD, DM, NASH, Malignancy and others
- Bariatric surgery has been shown to be the only effective treatment for weight loss/maintenance
- Also has profound metabolic effects including reversal of T2DM - Stampede trial
196
What is the rate of progression of non-dysplastic Barrett's to cancer?
0.22-0.38% per year
197
Who should patients with Barrett's with gastric metaplasia be managed?
Repeat biopsies, if short segment and confirmed Gastric --> discharge
198
How should patients with Barretts with LGD be managed?
Repeat OGD in 6 months, if confirmed --> Ablation
If absent, repeat at further 6 month interval
199
What is the anatomy of the thoracic duct?
- Drains lymph from the lower half of the body and abdomen at the cisterna-chyli (L1/L2)
- Runs superiorly along the right side of the vertebral column
- Runs in posterior mediastinum and crosses to left at about T4/T5
- Behind the left brachiocephalic vein and drains into the left subclavian
Transports about 2-4L of Chyle per day
Cons mx of chyle leak unlikely to be successful if >1L/day
Diet of Medium chain triglycerides (absorbed directly into portal venous system)
200
How does H.Pylori damage the stomach?
-Production of urease, ammonia, acetaldehyde and mucolytics
-Attract inflammatory cells and produce free radicals
-Cause acute and chronic gastritis
-Chronic superficial gastritis progresses to atrophic gastritis, intestinal metaplasia, dysplasia and cancer
201
What are the common complications of gastrectomy?
Immediate - Leak, duodenal stump blow out, haemorrhage
Late - dumping syndrome (early/late), vitamin deficiencies esp Vit B12 and Fe
Early dumping - fluid shifts from glucose in intestines
Late dumping - rebound hypoglycaemia
202
How should acid suppression be managed prior to pH monitoring?
Stop-
PPI 7 days
H2 3 days
antacids 1 day
203
How is a POEM performed?
GA
2cm longitudinal mucosal incision
Submucosal tunnel created similar to an ESD passing over OGJ to 3cm of stomach
Myotomy of circular layer of muscle performed keeping longitudinal layer intact
204
What is the normal Phi Angle?
4-58 degrees
205
Where might Internal Herniae occur after bypass surgery?
1) Peterson's space - between transverse colon mesentery and gastrojejunostomy
2) Small bowel mesenteric defect at JJ
3) If retrocolic --> through mesocolic defect
206
What follow up should patients endoscopically treated for HGD receive?
3 monthly for 1 year and yearly thereafter
207
How is EMR performed?
Sedation/GA
Excision margins marked with APC
Injected with mixture of adrenaline/gelofusine - if lifts, amenable to EMR
Mucosectomy device applies a rubber band to create a pseudo polyp and then excised
208
How would you perform a subtotal gastrectomy?
- Laparoscopic approach with 4 ports and liver retractor
- Dissection of greater omentum from transverse colon running from 1st short gastric to right gastroepiploic pedicle which is ligated with clips
- Division of posterior gastric adhesions including splenic artery nodes (11p)
- Division of gastrohepatic ligament and isolation/ligation of right gastric artery
- Mobilisation of 1st part of duodenum and division with a linear stapler
- Dissection of lymphatic tissue from CHA, coeliac axis and hepatoduodenal ligament (8/9/12)
- Left gastric artery then ligated at its origin (7)
- Dissection along lesser curve including pericardiac nodes
- Division of specimen 5cm proximal to tumour
- Reconstruction with roux-en-y technique
---- Division of jejunum at 50cm (BP Limb)
----50cm further jejunum taken and anastomosis of BP limb to jejunum at this level with linear stapler and closure of enteroenterostomy
----Antecolic, ante gastric Gastrojejunostomy created with linear stapler and closure of gastroenterostomy
----Closure of mesenteric defects with permanent suture
----Drain to duodenal stump
209
What is a MALT lymphoma?
Low grade lymphoma from gastric mucosa-associated lymphoid tissue
Form of B cell non-Hodgkin's lymphoma
210
From which cell type do GISTS arise?
Interstitial cells of Cajal
211
How should patients with an excised GIST be followed up?
High risk - 3 monthly for 2 years then 6 monthly for 2 years then annually
Intermediate risk - 3months post op, then 6 monthly for 2 years then annually
Low risk - 3 months post op then clinical
212
What is impedance monitoring?
Change of resistance to electric current when a bolus passes between two sensors
Liquids - high conductance (ions)
Gas - low conductance
213
How is the oesophagus approached in the neck?
- Left side of neck with head extends and turned to right
- Incision on anterior border lower 1/2 of SCM
- SCM dissected free from sternohyoid to identify internal jugular vein
- Anterior Omohyoid belly identified and divided
- Middle thyroid vein ligated and deep cervical fascia opened
- Carotid sheath retracted laterally
- Blunt dissection onto oesophagus via NGT.
214
What size circular stapler is used for Oesophageal anastomosis?
25mm (strictures if less than this)
215
What is Ghrelin?
Orexigenic hormone produced by fungus
Reduced by sleeve --> reduced hunger
216
How would you perform an Ivor-Lewis Oesophagectomy?
Minimally invasive approach
---- Abdominal phase - 4 ports, liver retractor
- Mobilisation of greater omentum with careful preservation of gastroepiploic arcade and division of short gastrics above this to hiatus
- Partial Kocherisation of duodenum to mobilise pylorus to hiatus
- Dissection of lymphatic tissue and ligation of LGA at origin
- Mobilisation of lesser curve of stomach including lymph nodes and wide dissection hiatus
- Sling oesophagus with Jaques catheter and dissect up into mediastinum as far as possible including pleural strip
- Divide stomach 5cm distal to tumour creating tubularised conduit
- Suture divided specimen to conduit
- Feeding jejunostomy and close
----Thoracic phase - 4 ports, single-lung ventilation, semi-prone right chest
- Continue pleural strip superiorly to azygos vein and divide between hemoloks
- Dissection of oesophagus including paraoesophagheal and carinal lymph nodes until free
- Ligate thoracic duct if identified
- Divide oesophagus proximally with linear stapler
- Open chest, extract specimen, prepare conduit
- Circular stapled anastomosis using Orville 25mm
- Passage of NGT past anastomosis and fixation at nose
- Gastrostomy excised with linear stapler and removed
- 2 x chest drain close
217
How is anaemia defined and initially investigated
Hb <12 Female, <13 Male
Microcytic, normocytic, macrocytic
OGD + Colonoscopy + D2 biopsies x 4 for coeliac + Urinalysis/micro
218
If initial investigations for IDA are negative how should you proceed?
BSG guidelines 2021 - trial of iron therapy
If recurrent or refractory --> Capsule endoscopy
Consider dummy capsule to exclude strictures (dissolvable material) with RFID
219
In patients undergoing investigation for IDA, when can a colonoscopy be safely omitted?
OG cancer diagnosed at OGD
220
What are the expected outcomes after LARS?
REFLUX 30% taking PPIs at 5 years
LOTUS 5 year symptom remission of 90%
Watson 20 year follow up - 90% satisfaction, 10% revision
-Satisfaction 90%
-Revision 10%
221
How is high resolution manometry conducted?
- Dedicated physiologist
- 32 sensor catheter
- Positioned at LES for 5 minutes
- 10 wet swallows of 10ml water
- Chicago V4 - 10 solid bolus swallows
- Measurement of oesophageal peristalsis and LES function
222
What is measured at high resolution manometry?
Identify basal LES pressure and PIP/Hiatus hernia
Measure IRP >15 abnormal
Assess peristaltic waves and short/long peristaltic defects
Contractile deceleration point (point when speed of waveform decreases)
Important measurements
IRP <15
DCI 450-5000
CVF <9cm/s
223
How are SEMS inserted?
- Either in CEPOD or IR with fluoroscopy available, usually under GA
- Visualisation of lesion
- Passage of guidewire beyond lesions and confirmation of position with fluoroscopy. May need to balloon up if not big enough
- Target landing zone identified on fluoroscopy and marked on surface
- Scope withdrawn and stent inserted
- Position confirmed and guidewire removed
- Stent deployed and visualised endoscopically
Cook stents
- Length of 8-14cm and diameter of 20mm
- Colon up to 35mm diameter
224
How should perforated oesophageal cancer be managed?
If not resectable --> SEMS
If resectable best served by resection
Could exclude and bypass
Outcomes poor
225
How should perforated gastric cancer be managed?
With an R0 resection
If R0 not achievable then median survival a few months
226
What is the COMMANDO operation?
Combined mandibulectomy and neck dissection operation
(Tongue malignancy)
Glossessctomy, hemimandibulectomy, block dissection of cervical nodes
227
How should patients with symptoms after LARS be managed?
--Distinguish between Failure (never worked), dysfunction (better then worse) or complication (new symptoms)
Technical causes
-- intrathoracic migration - OGD/Barium -- revision
-- torsion -- Barium -- revision
-- Crural stenosis - OGD/Barium -- revision
-- oesophageal pathology (eosinophilic oesophagitis/motor disorders)
-- HH recurrence/failed wrap
Horgan classification for failed Fundoplication
Type 1 - GEJ herniated through hiatus +/- fundoplication
Type 2 - Paraoesophageal hernia component from redundant fundoplication
Type 3 - malformation of fundoplication
Treatment
Ix -- OGD + biopsies, Barium, Manometry/pH
If failed or new symptoms, consider re-do surgery
If dysphagia and no anatomical abnormalities consider prokinetics or dilatation
228
What are the risks of complications after oesophagectomy?
ESOdata 3000 patients
30d mortality - 2.5%
Any comp - 60%
Major comp(3b-5) 16.8%
Anastomotic Leak 11%
Chyle leak 5%
RLN injury 4.2%
Respiratory 27.8%
Cardiac 16.8%
229
What are the risks of complications after gastrectomy?
DUCA 2019 1600
30d mortality 4.4%
Any complication 43%
Major complication 20%
Anastomotic Leak 9%
Respiratory 17%
Cardiac 5%
Chyle leak 2%
230
What are the risk of RLN after oesophagectomy?
McKeown (14%) or Transhiatal (2%)
Thermal injury, stretching, compression
Significant increase in risk of pulmonary complications, tracheostomy
>50% present after aspiration
may require medialisation
231
What is sucralfate?
Aluminium salt
Binds to positively charged proteins in exudates locally forming a thick viscus coating for ulcers, also reduces pepsin and increases bicarb
FDA approved for DU healing
Can be used for dyspepsia, radiation proctitis, diversion colitis, stress ulcer prophylaxis
Negligible side effects - constipation (avoid in ESRF)
232
What is the course of the vagus nerve?
Exits cranium via jugular foramen (with IX and XI), passing in carotid sheath.
R+L deviate at base of neck
--Right passes anterior to SCA and posterior to SCJ entering the thorax. RRLN hooks underneath RSCA
---Posterior vagal trunk in chest
--Left passes inferiorly between L CCA/SCA into thorax. LRLN hooks underneath arch of aorta
---Anterior vagal trunk in chest (branches from both form oesophageal plexus)
233
How should a perforation at LARS be managed?
If intra-operative - primary repair and drain and confirm healing with WSCS
If post-op - oesophagus --> drain +/- primary repair +/- T-Tube +/- SEMS
stomach --> primary repair or resection
234
What is the cause of diarrhoea post LARS?
Vagotomy
Small bowel bacterial overgrowth
Bile salt malabsorption
235
What is the differential diagnosis of dysphagia?
Intrinsic
- Stricture (benign peptic, malignant, leiomyoma)
- Eosinophilic oesophageal ring or Plummer Vinson syndrome
Food bolus
- Zenkers diverticulum
Neurological/motility
- Stroke, dementia, MS
- Achalasia, DES, Scleroderma
Extrinsic
- Mediastinal mass
- LAH
- Dysphagia lusoria
236
What is the arterial and venous supply of the stomach?
Venous
-- LGE and Short gastrics --> Splenic vein (nb is joined by IMV)
-- RGE --> SMV
-- LG and RG --> Portal vein
237
After dCRT, where is a salvage Esophagectomy useful?
dCRT uses 50Gy (vs 30-41.4 NA)
Failure rate of 38% local, 13% regional and 16% distal
NACRT vs dCRT two trials in 2005/2007 - improved local control but no difference in overall survival (but very high operative mortality of 9-10%)
If loco regional recurrence then may be useful
Avoid anastomosis in irradiated fields, consider 3 phase.
Risk of airway injury/anastomotic break down. May need to consider a colonic interposition.
NEEDS trial recruiting CRT + Surgery vs CRT + salvage if needed
238
What is Tylosis?
Palmoplantar keratosis associated with leukoplakia and Oesophageal SCC
AD inheritance, Howel-Evans Syndrome
RHBDF2 gene --> EGFR
239
What is Bloom syndrome?
Abnormality of BLM gene, DNA repair
Leukaemia, Lymphoma, Oesophageal SCC
Short, T2DM
240
What is Fanconi Anaemia?
AR inheritance, more common in Ashkenazi Jews
AML, physical abnormalities
mucosal SCCs including Oesophageal not cured by BMT
241
What is hereditary diffuse gastric cancer?
CDH 1 gene, AD inheritance
Diffuse Gastric cancer + Lobular breast cancer
242
What is the pathophysiology seen in dumping syndrome?
Early - hyperosmolar nutrients in small bowel --> fluid shifts
--> reduction in plasma volume, tachycardia, syncope, along with distension of bowel, pain, diarrhoea
Late - Rapid glucose absorption --> Exaggerated GLP1 and insulin --> autonomic and neurogylcopenic symptoms
243
What is the Mandard tumour regression grade?
1 - fibrosis only
2- isolated tumour cells
3 - fibrosis outgrowing tumour
4 - tumour outgrowing fibrosis
5 - no regression
244
What is the key molecular marker seen in SCC oesophagus?
p53 mutation 80%
over expression cyclin D1 20-40%
245
What are the different zones of the oesophagus?
Cervical - lower border of cricoid to thoracic inlet (to 18cm)
Upper 1/3 - 18-24cm
Middle 1/3 - 24-32cm
Lower 1/3 - 32-40cm
