Ocular Side Effects of Systemic Drugs

Question 1

Amiodarone

Answer 1

for cardiac arrhythmia
optic neuropathy
mild decreased VAs, VF defect, optic disc swelling
whorl shaped pigment deposits in corneal epithelium

Question 2

Bisphosphonates

Answer 2

for osteoporosis -dronate

red eye, photophobia, decreased vision, boring eye pain

Question 3

Chlorpromazine

Answer 3

for schizophrenia

punctate opacities in corneal epithelium after long term use

Question 4

Corticosteroids

Answer 4

posterior subcapsular cataracts

increased IOP

Question 5

Diphenylhydantoin

Answer 5

for seizures

horizontal and vertical nystagmus, diplopia, ataxia

Question 6

Tamoxifen

Answer 6

for breast cancer
whorl opacities in cornea
retinal crystalline deposits, macular edema, cataracts, optic neuritis

Question 7

Sildenafil, Vardenafil, Tadalafil

Answer 7

for ED
impaired color vision- blue tint to vision
nonarthritic ischemic optic neuropathy

Question 8

HMG-CoA Reductase Inhibitors

Statins

Answer 8

for lowering cholesterol

cataracts

Question 9

Tetracyclines

Answer 9

for Rocky Mountain Spotted Fever, cholera, Lyme disease
pseudotumor cerebri- increased ICP
photosensitivity
discolors teeth if under age 8

Question 10

Thioridazine

Answer 10

for schizophrenia

pigmentary retinopathy with doses +1000mg

Question 11

Topiramate

Answer 11

for seizures
acute bilateral angle closure glaucoma- ciliary body swelling
acute eye pain, redness, blurred vision, halos

Question 12

Ethambutol

Answer 12

for TB
optic neuropathy
permanent vision loss

Question 13

Digitalis

Answer 13

blood thinner

blurred vision or abnormal color vision- see yellow

Question 14

Chloroquine

Answer 14

for malaria, RA, lupus

corneal deposits and retinopathy, bulls eye macular lesion

Question 15

Hydroxychloroquine

Answer 15

for RA, lupus, malaria
vision loss
keep dosing under 5mg/kg; around 300mg