octreotide (octreoscan) Flashcards

1
Q

what is octreotide

A

-aka pentetreotide
-somatostatin-peptide-14-amino acid

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2
Q

peptide is…

A

portion of amino acid that naturally binds to recpetors on cell surface

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3
Q

somatostatin is…

A

a growth hormone release inhibiting factor that is concentrated in the hypothalamus, cerebral cortex, brain stem, gi tract, and pancreas

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4
Q

what is octreotide used for

A

peptide not a MoAb
-scan + treatment
reduces diarreha in therapy pt sometimes

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5
Q

functions

A

prevents release of GH from pituitary gland and releases several other hormones affecting GI system

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6
Q

how do somatostatins help sympotms

A

treat symptoms when tumors oversecretes hormones- tumors have incr # of somatostatin receptors so octreotide binds to receptors

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7
Q

what receptor sites does octeotride have

A

somatostatin sites

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8
Q

what can octreotide localzie

A

primary and mets originating for neuroendocrine tumorsar

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9
Q

carcinoid

A

hormone producing cell

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10
Q

neuroblastomas

A

tumor on heme tissue

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11
Q

pheochromocytomas

A

adrenal glands (heart rate BP)

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12
Q

how to make

A

6 mCi In-111 chloride solution to penetreotide vial
-kit
-30 min incubate

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13
Q

when do inject and make kit

A

make kit upon pt arrival bc expensive, scan following day
-inject IV

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14
Q

what does kit come in and why

A

kit comes in glass and syringe in plastic
-x-rays attenuated by glass vial but not syringe so calibrator measurement high in syringe vs glass vial

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15
Q

pt prep

A

laxatives to clear GI tracts and off octeotride therpay for 24 hours bc those cells bound to nonradioactive substance already

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16
Q

at how many hours do we scan

A

at 24 hours

17
Q

what cam do we use for WB

A

670

18
Q

how long is WB

A

10 min mid thigh-> top of head

19
Q

do we SPECT and how long if so

A

SPECT 40 sec/frame. 1,2, or 3 FOV depening on ROI

20
Q

what collimator

A

medium

21
Q

energies used

A

173 keV and 247 keV

22
Q

total time pt is on camera

A

2-3 hours

23
Q

biodistribution/ excretion

A

rapidly leaves blood after injection
-excretion by kidneys exclusively

24
Q

normal places itll show up on scan

A

pituitary, thyroid gland, liver, spleen, kidneys, bladder, and gallbladder

25
Q

what line should never be injected

A

TPN line