Occupational And Environmental Lung Disease Flashcards
Which particles (coarse-mode, fine-mode and ultrafine) make up the largest number of particles, tend to remain in the airstream, and deposit in the lung on a random basis?
Ultrafine
What are the major effects from exposure to asbestos?
Pleural and pulmonary fibrosis, cancers of the respiratory tract, pleural and peritoneal mesothelioma
Chest radiographic hallmark of asbestosis?
Irregular or linear opacities first noted in the lower lung fields
True or False. Mesotheliomas are associated with smoking.
False. Think asbestos exposure..>80% of mesotheliomas may be associated with asbestos exposure.
PFT-Respiratory pattern found in Asbestosis.
Restrictive Pattern with decrease in both lung volumes and diffusing capacities.
Characteristic HRCT pattern “crazy paving”
Silicosis
Small rounded opacities in the upper lobes may appear on chest radiograph after 15-20 years of exposure usually without associated impairment of lung function
Simple silicosis
Progressive nodular fibrosis in the absence of further exposure with coalescence and formation of nonsegmental conglomerates of irregular masses> 1cm
Complicated silicosis
What connective tissue disorder are potential clinical complications of Silicosis?
Rheumatoid arthritis and scleroderma
Exposure to coal can lead to the ff condtions 3Cs
CWP- Coal worker’s pneumoconiosis Chronic bronchitis COPD
First described in coal miners, coal miners but subsequently in patients with silicosis. Pneumoconiotic nodules + Seropositive Rheumatoid Arthritis
Caplan syndrome
What metal is a lightweight metal with tensile strength, good electrical activity and value in the control of nuclear reactions through its ability to quench neutrons?
Beryllium
How will you measure cell mediated immune response to beryllium?
Beryllium lymphocyte proliferation test
Diagnostic test for Chronic Beryllium Disease
Fiberoptic bronchoscopy with transbronchial lung biopsy
