Oc Pharm (Peds)

Question 1

Which drug is likely worse to use in Peds pop – NE or NR?

Answer 1

likely NR (not recommended) - animal studies or anecdotal cases have ADRs or hazards to peds pop

NE (not established) - we don’t know yet. lack of research

Question 2

A newborn eye is how big compared to an adult eye? At what age does it reach adult size? Why important?

Answer 2

2/3 adult size; reaches adult levels at 3-4 yrs

-relatively large eye compared to body; at greater risk of SYSTEMIC S/Es

Question 3

physiological differences in KIDS compared to adults (ADME)

Answer 3

A-more permeable tissues, less GI motility, supine position=more absorption
D-less circulating blood = more concentrated, less effective BBB
M-metabolism less effective
E-GFR and secretion immature in first year

Question 4

• Disadvantages to topical DROPS (vs ointment)?
• Disadvantages to topical OINTMENT?
• Three commonly used ORALS in kids [ada - CLASSES of drugs]?

Answer 4

• drop disadv: SYSTEMIC ABSORPTION, minimal contact time, difficult administration
• oint disadv: blurry VA, potential for contact dermatitis
• orals: antihistamines, decongestants, antibiotics

Question 5

MOST COMMON CAUSE of anterior uveitis in kids? What steroids CAN you use to tx?

Answer 5

JIA!!

CAN use FML (approved), or non-approved if severe (pred forte, durezol, rimexolone)

Question 6

How to tx pediatric glaucoma

Answer 6

REFER. Cosopt, Alphagan, Combigan all approved for >2yrs, but just send it out.

Question 7

Major conclusion from the VIP HIP study?

Answer 7

LEARNING AND VISION ARE RELATED