Obstructive Airway Disease Flashcards
Airways
Obstructive
Lungs
Restrictive
Name the 3 most common OBSTRUCTIVE airway conditions.
Asthma
Chronic bronchitis
Emphysema
What is ACOS? What type of condition is it?
Asthma and COPD overlap syndrome
Obstructive
If mucosa becomes larger, the ….. becomes smaller
Lumen
Name the 3 points of the Asthma Triad.
- Airway inflammation
- Airway hyperresponsiveness
- Reversible airflow obstruction
Describe airway hyper-responsiveness.
Easily triggered bronchospasm
What are the 3 stages in the evolution of Asthma.
- Bronchoconstriction
- Chronic airway inflammation
- Airway remodelling
Fixed airway obstruction is known as what stage?
Stage 3 - airway remodelling
Bronchoconstriction causes ….. symptoms
BRIEF
What are the 3 hallmarks of airway remodelling in asthma? State which layer they arise in.
- Thickening - basement membrane
- Collagen deposition - submucosa
- Hypertrophy - smooth muscle
What drug is given in eosinophilic inflammation?
Anti-inflammatory
e.g Corticosteroid
What drug is given to mediate TH2 cytokines?
Anti-leukotrience/histamine
Anti-IgE
Anti-IL5
What drug is given for twitchy smooth muscle (hyper-reactivity)?
Bronchodilatory
e.g beta2-agonist, muscarinic antagonist
Name some potential allergens (triggers) in asthma.
Animal dander
Dust mites
Pollens
Fungi
The signs and symptoms of asthma are ……..
EPISODIC
Asthma patients usually have a productive cough
FALSE
non-productive
Why do people get a wheeze?
Turbulent airflow
People with asthma usually have associated …….
Atopy
Name 3 conditions which are closely associated with asthma (esp atopy related)
Rhinitis
Conjunctivitis
Eczema
Describe the day time variation in asthma.
DIURINAL
Describe the forced expiratory ratio in asthma. Explain this.
<75% - REDUCED
FEV1 is reduced
FVC is normal