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RESPIRATORY > Airway Therapeutics > Flashcards

Airway Therapeutics Flashcards

1
Q

Preventors

A

Anti-inflammatory

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2
Q

Reliveres

A

Bronchodilators

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3
Q

List the 4 stages of the inflammatory cascade in Asthma

A
  1. Genetics + triggers
  2. Eosinophilic inflammation
  3. CH2 cytokines
  4. Hyper-reactivity
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4
Q

Name some triggers.

A

Virus
Allergens
Chemicals
Nutrition

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5
Q

What is given for eosinophilic inflammation?

A

Corticosteroids

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6
Q

What is given for CH2 cytokines?

A

Anti-leukotrience/histamine
Anti-IgE
Anti-IL5

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7
Q

What is given for hyper-reactivity?

A

Bronchodilators e.g
Beta 2 agonist
Muscarinic antagonists

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8
Q

Outline the management plan for asthma.

A

????

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9
Q

What might happen after giving a patient with COPD a corticosteroid?

A

Pneumona

They will have immune suppression from the steroid and impaired mucocillary clearance from COPD

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10
Q

What is used for an acute exacerbation of COPD?

A

Oral steroid e.g Prednisolone

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11
Q

What inhaled steroid is used for maintenance mono-therapy in asthma?

A

Belomethasone

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12
Q

Prednisolone has a low therapeutic index?

A

TRUE

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13
Q

Beclomethasone has a low therapeutic index?

A

FALSE

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14
Q

What reduces exacerbations in eosinophilic COPD aka ACOS?

A

Corticosteroids

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15
Q

How can optimum delivery be achieved?

A

Use a spacer

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16
Q

What does a spacer reduce?

A

Thrush

Particle size and velocity

17
Q

ONLY USE CROMONES IN….

A

ASTHMA

18
Q

What is the function of a leukotriene receptor agonist?

A

Anti-inflammatory

19
Q

What condition are LRA’s used in?

A

Asthma

20
Q

Name an LRA?

A

Monteleukast

21
Q

Describe monteleukast.

A

Oral
ONCE daily
High therapeutic ratio

22
Q

What is more potent, an inhaled steroid or LRA?

A

LRA

23
Q

Name an anti-IgE monoclonal antibody?

A

Omaluzimab

24
Q

What do anti-IgE drugs do?

A

Inhibits binding to IgE and inhibits mediator release from basophils and mast cells

25
Q

How often is anti-IgE drugs given?

A

Injection every 2-4 weeks for asthma only

26
Q

What is given to patients with severe persistent allergic asthma?

A

Anti-IgE

27
Q

What is IL5 responsible for?

A

Eosinophilic inflammation in asthma

28
Q

Name an anti-IL5 drug.

A

Mepolizumab

‘umab’

29
Q

What do muscarinic receptors 1 enhance?

A

Cholingeric reflex

30
Q

What do m2 receptors inhibit?

A

ACh release

31
Q

What do m3 receptors do?

A

Mediate bronchoconstriction and mucous secretion

32
Q

Muscarinic antagonists are?

A

Anti-cholingeric

33
Q

What do muscarinic antagonists block?

A

M3

34
Q

Short acting muscarinic antagonist?

A

Ipratropium

35
Q

Long acting muscarinic antagonist?

A

Tiotropium

36
Q

What is oral theophylline used for?

A

Maintenance in asthma
Nocturnal dips
BRONCHODILATOR AND ANTI-INFLAMMATORY

37
Q

Outline the management of COPD.

A
  1. LAMA
  2. LABA
  3. LAMA + LABA
  4. LABA + ICS
  5. LABA + LAMA + ICS

RESPIRATORY (14 decks)

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