Airway Therapeutics

Question 1

Preventors

Answer 1

Anti-inflammatory

Question 2

Reliveres

Answer 2

Bronchodilators

Question 3

List the 4 stages of the inflammatory cascade in Asthma

Answer 3

1. Genetics + triggers
2. Eosinophilic inflammation
3. CH2 cytokines
4. Hyper-reactivity

Question 4

Name some triggers.

Answer 4

Virus
Allergens
Chemicals
Nutrition

Question 5

What is given for eosinophilic inflammation?

Answer 5

Corticosteroids

Question 6

What is given for CH2 cytokines?

Answer 6

Anti-leukotrience/histamine
Anti-IgE
Anti-IL5

Question 7

What is given for hyper-reactivity?

Answer 7

Bronchodilators e.g
Beta 2 agonist
Muscarinic antagonists

Question 8

Outline the management plan for asthma.

Answer 8

????

Question 9

What might happen after giving a patient with COPD a corticosteroid?

Answer 9

Pneumona

They will have immune suppression from the steroid and impaired mucocillary clearance from COPD

Question 10

What is used for an acute exacerbation of COPD?

Answer 10

Oral steroid e.g Prednisolone

Question 11

What inhaled steroid is used for maintenance mono-therapy in asthma?

Answer 11

Belomethasone

Question 12

Prednisolone has a low therapeutic index?

Answer 12

TRUE

Question 13

Beclomethasone has a low therapeutic index?

Answer 13

FALSE

Question 14

What reduces exacerbations in eosinophilic COPD aka ACOS?

Answer 14

Corticosteroids

Question 15

How can optimum delivery be achieved?

Answer 15

Use a spacer

Question 16

What does a spacer reduce?

Answer 16

Thrush

Particle size and velocity

Question 17

ONLY USE CROMONES IN….

Answer 17

ASTHMA

Question 18

What is the function of a leukotriene receptor agonist?

Answer 18

Anti-inflammatory

Question 19

What condition are LRA’s used in?

Answer 19

Asthma

Question 20

Name an LRA?

Answer 20

Monteleukast

Question 21

Describe monteleukast.

Answer 21

Oral
ONCE daily
High therapeutic ratio

Question 22

What is more potent, an inhaled steroid or LRA?

Answer 22

LRA

Question 23

Name an anti-IgE monoclonal antibody?

Answer 23

Omaluzimab

Question 24

What do anti-IgE drugs do?

Answer 24

Inhibits binding to IgE and inhibits mediator release from basophils and mast cells

Question 25

How often is anti-IgE drugs given?

Answer 25

Injection every 2-4 weeks for asthma only

Question 26

What is given to patients with severe persistent allergic asthma?

Answer 26

Anti-IgE

Question 27

What is IL5 responsible for?

Answer 27

Eosinophilic inflammation in asthma

Question 28

Name an anti-IL5 drug.

Answer 28

Mepolizumab | 'umab'

Question 29

What do muscarinic receptors 1 enhance?

Answer 29

Cholingeric reflex

Question 30

What do m2 receptors inhibit?

Answer 30

ACh release

Question 31

What do m3 receptors do?

Answer 31

Mediate bronchoconstriction and mucous secretion

Question 32

Muscarinic antagonists are?

Answer 32

Anti-cholingeric

Question 33

What do muscarinic antagonists block?

Answer 33

M3

Question 34

Short acting muscarinic antagonist?

Answer 34

Ipratropium

Question 35

Long acting muscarinic antagonist?

Answer 35

Tiotropium

Question 36

What is oral theophylline used for?

Answer 36

Maintenance in asthma Nocturnal dips BRONCHODILATOR AND ANTI-INFLAMMATORY

Question 37

Outline the management of COPD.

Answer 37

1. LAMA 2. LABA 3. LAMA + LABA 4. LABA + ICS 5. LABA + LAMA + ICS