Obstetrics Flashcards
What is an ectopic pregnancy?
embryo implanted outside the uterus
What is the most common site for ectopic pregnancy?
fallopian tube
What are possible locations for an ectopic pregnancy?
- MC tubal (ampulla)
- most danger of rupture in isthmus
- ovary, cervix, peritoneum
What are the risk factors for ectopic pregnancy?
- previous ectopic
- previous pelvic inflammatory
- tubal damage
- IVF
- IUD/IUS/POP
- older age
- smoking
What is the presentation of an ectopic pregnancy?
- vaginal bleeding
- missed period
- lower abdominal pain (L/RIF)
- lower abdo/pelvic tenderness
- cervical motion tenderness - chandelier sign
- shoulder tip pain (bleeding irritates diaphragm)
- dizziness
What investigations are done for an ectopic pregnancy?
- transvaginal ultrasound scan
- gestational sac containing a yolk sac or fetal pole
What is seen on USS for an ectopic?
- non-specific mass containing empty gestational sac
- blob/bagel/tubal ring sign
- mass moves separately to ovary (corpus lutem would move with ovary)
- empty/fluid filled uterus
What are the criteria for conservative management of an ectopic?
- for minimal/no symptoms
- repeat β-hCG testing
- unruptured ectopic
- adnexal mass <35mm
- no visible heartbeat
- no significant pain
- hCG < 1500 IU/l
What does medical management of an ectopic pregnancy involve and what are the criteria?
- hCG <1500IU/L
- confirmed absence of IU pregnancy on USS
- IM methotrexate in buttock
- teratogenic - spontaneous termination
What are the side effects of methotrexate?
- vaginal bleeding
- n+v
- abdo pain
- stomatitis
- advised not to get pregnant for 3 months
What are the criteria for surgical management of ectopic pregnancy?
- ruptured
- pain
- adnexal mass >35mm
- visible heartbeat
- hCG >5000 IU/l
What is a salpingectomy?
removal of the fallopian tube (containing the ectopic pregnancy)
What is a salpingotomy?
- used in women with inc risk of infertility due to other damaged tube
- cut made in tube, ectopic removed and tube closed
What is pregnancy of unknown location?
- positive pregnancy test but no intra/extrauterine evidence of pregnancy on transvaginal USS
How is pregnancy of unknown location monitored?
- serum hCG tracked and repeated over 48hrs
- monitor clinical signs or symptoms
What rises in hCG indicate which types of pregnancy?
- rise of > 63% intrauterine pregnancy
- <63% indicates ectopic
- fall of >50% indicates miscarriage
What is a missed miscarriage?
- fetus no longer alive
- no symptoms occurred
What is a complete miscarriage?
- full miscarriage
- no products of conceptions left in the uterus
What is an incomplete miscarriage?
- products of conception retained in the uterus
What is a threatened miscarriage?
- vaginal bleeding
- closed cervix
- fetus is alive
- little/no pain
What are the symptoms of an inevitable miscarriage?
- heavy vaginal bleeding
- pain
- open cervix
How is miscarriage diagnosed?
- transvaginal ultrasound
- mean gestational sac diameter
- fetal pole and crown-rump length
- fetal heartbeat
How does fetal heartbeat affect crown-rump length?
- heartbeat expected when length is 7mm or more
- if less than 7mm, scan is repeated after 1 week to ensure heartbeat develops
- 7mm+ and no heartbeat = non-viable pregnancy
What is an anembryonic pregnancy?
- gestational sac is present
- no embryo
When is a fetal pole seen?
- expected when mean gestational sac diameter is >25mm
- if this is present without a fetal pole:
- repeat scan after 1 week then confirm anembryonic pregnancy
How is a miscarriage of <6 weeks gestation managed?
- expectant management
- awaiting without investigations and treatment
- repeat urine pregnancy test after 3 weeks
- if negative a miscarriage can be confirmed
How is a miscarriage of >6 weeks gestation managed?
- early pregnancy assessment service referral (EPAU)
- arrange USS to confirm location and viability
- consider and exclude ectopic
What is expectant management of a miscarriage?
- 1st line without risk factors for heavy bleeding and pregnancy
- 1-2 weeks to allow it to occur spontaneously
- repeat urine pregnancy after 3 weeks to confirm complete
- persistent/worsening bleeding requires further assessment and repeat USS in case of incomplete miscarriage
What is medical management of a miscarriage?
- misoprostol
- vaginal suppository or oral
- causes heavier bleeding, pain, vomiting, diarrhoea
What is surgical management of miscarriage?
- give misoprostol
- manual vacuum aspiration
- electric vacuum aspiration
How does manual vacuum aspiration work?
- local anaesthetic applied to cervix
- syringe inserted through
-<10 weeks gestation - more appropriate for parous women
How does electric vacuum aspiration work?
- traditional surgical management
- general anaesthetic
- cervix widened with dilators
- pregnancy removed with electric powered vacuum
How is incomplete miscarriage managed?
- retained products carry infection risk
- misoprostol or evacuation
- ERPC using vacuum aspiration and curettage (scraping)
- complication is endometriosis
What is hyperemesis gravidarum?
- vomiting a lot during pregnancy
What are the RCOG guidelines for hyperemesis?
- more than 5% weight loss compared with before pregnancy
- dehydration
- electrolyte imbalance
How is the severity of hyperemesis assessed?
- pregnancy-unique quantification of emesis (PUQE)
- <7 = mild
- 7-12 = moderate
- > 12 = severe
What is the management of hyperemesis?
- antiemetics
1. prochlorperazine
2. cyclizine
3. ondansetron
4. metoclopramide
How is severe hyperemesis managed?
- IV/IM antiemetics
- IV fluids
- KCl for hypokalaemia
- thiamine and folic acid to prevent Wernicke’s encephalopathy
- TED stockings and LmwH
When should admission be considered in hyperemesis?
- unable to tolerate antiemetics
- more than 5% weight loss vs prepregnancy
- ketones present (2+ is significant)
What is the definition of recurrent miscarriage?
- three or more miscarriages
What are the causes of recurrent miscarriage?
- smoking
- antiphospholipid syndrome
- hereditary thrombophilia
- uterine abnormalities
- chronic disease: diabetes, SLE, thyroid
- genetic factors
What is PPH?
- post partum haemorrhage
- bleeding after delivering baby and placenta
- most common cause of significant obstetric haemorrhage
How much blood loss is needed to be classified as PPH?
- 500ml after vaginal delivery
- 1000ml after c-section
What is the difference between major and minor PPH?
- Minor: under 1000ml
- Major: over 1000ml
How can major PPH be subclassified?
- Moderate: 1000-2000ml loss
- Severe >2000ml loss
What is the difference between primary and secondary PPH?
Primary: within 24hrs of birth
Secondary: between 24hrs - 12 weeks after birth
What are the causes of PPH (4 T’s)?
- tone (uterine atony)
- trauma (perineal tear)
- tissue (retained POC)
- thrombin (bleeding disorder)
What are risk factors for PPH?
- previous PPH
- retained placenta
- placenta accreta
- instrumental delivery
- multiple pregnancy
- macrosomia
- prolonged 3rd stage
- failure to progress from 2nd stage
What are some preventative measures for PPH?
- treating anaemia during antenatal period
- giving birth w empty bladder
- active management of 3rd stage
- IV tranexamic acid (in 3rd stage C-section in high risk pt)
What is mechanical treatment of PPH?
- rubbing uterus to stimulate contraction
- catheterisation (bladder distention prevents contractions)
What is medical treatment of PPH?
- oxytocin
- ergometrine (IV/IM) stimulates smooth muscle contraction
- carboprost/misprostol: prostaglandin analogues stimulating uterine contraction
- tranexamic acid: antifibrinolytic
What is surgical treatment of PPH?
- IU balloon tamponade: presses against bleeding
- B-lynch suture: suture around uterus to compress
- uterine artery ligation
- hysterectomy
What causes secondary PPH?
- most likely due to retained products of conception or infection
How is secondary PPH investigated?
- USS for RPOC
- endocervical and high vaginal swabs for infection
How is secondary PPH managed?
- surgical evacuation for RPOC
- Abx for infection
What is placental abruption?
when the placental separates from the uterine wall during pregnancy
What does placental abruption lead to?
- site of attachment can bleed
- significant cause of antepartum haemorrhage
What are risk factors for placental abruption?
- prev abruption
- pre-eclampsia
- trauma
- multiple pregnancy
- inc maternal age
- smoking/cocaine
- multiparity/gravida
How does placental abruption present?
- woody, hard uterus
- sudden onset, severe, continuous abdo pain
- vaginal bleeding
- hypovolaemic shock
- dec fetal movements and distress on CTG
How is the severity of antepartum haemorrhage defined?
- spotting: spots on underwear
- minor: <50ml blood loss
- major: 50-1000ml loss
- massive: >1000ml or signs of shock
What is a concealed abruption?
- cervical os remains closed
- bleeding remains within uterine cavity
When are steroids given in placental abruption?
- between 24 and 34+6 weeks
- mature fetal lungs
- in anticipation of preterm delivery
What is the management of abruption?
- FBC, U&Es, LFT, coagulation
- crossmatch 4 units
- CTG of foetus and monitor mother
- fluid and blood resus as required
- senior obstetrician, midwife, anaesthetist
What is placenta praevia?
- low lying placenta, potentially covering cervical os
- lower than presenting part (part of baby to be delivered first - head in cephalic presentation) of the fetus
What is the difference between low-lying placenta and placenta praevia?
- low-lying: within 20mm of os
- praevia: placenta is over os
What can placenta praevia cause?
- antepartum haemorrhage
- emergency c-section
- emergency hysterectomy
- maternal anaemia and transfusion
- preterm birth and low weight
- stillbirth
What are risk factors for placenta praevia?
- prev c-sections
- prev praevia
- older age
- smoking
- uterine abnormalities
- IVF
What are the grades of praevia?
- minor/grade 1: in lower uterus but not reaching os
- marginal/grade 2: reaching but not covering os
- partial/grade 3: partially covering os
- complete/grade 4: completely covering os
What is the presentation of placenta praevia?
- painless bright red vaginal bleeding
- occurs after 24 weeks
What is the management of placenta praevia?
- if diagnosed early:
- repeat TVUS at 32 and 36 weeks
- corticosteroids 34 - 35+6 weeks to mature fetal lungs
- planned delivery 36-37 weeks
- planned C-section
- emergency c-section if premature labour/antenatal bleeding
What is a perineal tear?
- when external vaginal opening is too narrow for baby
- tearing of skin and tissues
What are risk factors for perineal tears?
- first baby
- large baby (over 4kg)
- shoulder dystocia
- Asian ethnicity
- occipito-posterior position
- instrumental deliveries
How are perineal tears classified?
- 1st degree: frenulum of posterior labia minor and superficial skin
- 2nd: including perineal muscles
- 3rd: including anal sphincter
- 4th: including rectal mucosa
How are 3rd degree tears subcategorised?
- 3a: <50% of ext sphincter affected
- 3b: >50% ext sphincter affected
- 3c: ext and int sphincter affected
What are the short term complications of tears?
- pain
- infection
- bleeding
What are the long lasting complications of perineal tears?
- urinary incontinence
- anal incontinence/altered bowel habit (3rd/4th degree)
- rectovaginal fistula
- sexual dysfunction and dyspareunia
- psych and mental consequences
What is the management of tears?
- 1st: none
- 2nd: suture
- 3rd/4th: theatre + elective C-section for subsequent pregnancies
- antibiotics
- laxatives
- physio and followup
What is an episiotomy?
- cuts perineum before delivery - anticipation
- 45 degree diagonal from vagina, downwards and laterally
- mediolateral episiotomy
- sutured after delivery
What is perineal massage?
- reduces risk
- massaging skin and tissues
- from 34 weeks
What is shoulder dystocia?
- anterior shoulder becomes stuck behind pubic symphysis after head has been delivered
What is a cause of shoulder dystocia?
- macrosomia (large baby)
- secondary to gestational diabetes
- advanced maternal age
- short stature
- small pelvis
- gestation >42 weeks
How does shoulder dystocia present?
- difficulty delivering face and head
- failure of restitution (baby head remains downwards (occipito- anterior))
- turtle-neck sign: head is delivered then retracts back into vagina
What are complications of shoulder dystocia?
- fetal hypoxia (+ subsequent cerebral palsy)
- brachial plexus injury
- perineal tear
- PPH
Why should fundal pressure not be applied in shoulder dystocia?
- can lead to uterine rupture
- may exacerbate shoulder impaction
- discouraging maternal pushing
What is the 1st line manoeuvre for shoulder dystocia?
- McRobert’s manoeuvre
- hyperflexion of hip to provide posterior pelvic tilt
- knees to abdomen
- moves pubic symphysis out of way
What is the second line manoeuvre for shoulder dystocia?
- suprapubic pressure
- pressure on the posterior aspect of the anterior shoulder
- encourages it down and under the pubic symphysis
What is Rubins and Wood’s screw manoeuvre?
- Rubins: reaching into vagina to put pressure on posterior aspect of anterior shoulder to move under symphysis
- Wood’s: other hand reaches inside to put pressure on anterior aspect of posterior shoulder
- top shoulder pushed forwards and bottom pushed back
- rotates baby and helps delivery
- opposite can be tried
What is the last line manoeuvre for shoulder dystocia?
- Zavanelli manoeuvre
- pushing baby’s head back into vagina for emergency C-section
What is instrumental delivery?
- vaginal delivery with ventouse suction cup or forceps
What are key indications for instrumental delivery?
- failure to progress
- fetal distress
- maternal exhaustion
- control of head in various fetal positions
What are the risks to the mother with instrumental delivery?
- PPH
- episiotomy
- perineal tears
- injury to anal sphincter
- bladder/bowel incontinence
- obturator/femoral nerve injury
What are the key risks to the baby with instrumental delivery?
- cephalohaematoma with ventouse
- facial nerve palsy with forceps
What more serious risks are there to the baby with instrumental delivery?
- subgaleal haemorrhage
- intracranial haemorrhage
- skull fracture
- spinal cord injury
What is a cephalohaematoma?
- collection of blood between the skull and periosteum (membrane covering bones)
What is ventouse?
- a suction cup on a cord
- cup goes on baby’s head
- careful traction on cord to pull baby out
What are forceps?
- two pieces of curved metal allowing grip of baby’s head
- can cause facial nerve palsy or facial paralysis
- can cause bruising or fat necrosis
What occurs in femoral nerve compression?
- femoral nerve compressed against inguinal canal
- weakness of knee adduction
- loss of patella reflex
- numbness of anterior thigh and medial lower leg
What occurs in obturator nerve compression?
- weakness of hip adduction and rotation
- numbness of medial thigh
At how many weeks gestation is induction of labour offered?
- 41-42 weeks
When is induction of labour beneficial?
- pre labour ROM
- fetal growth restriction
- pre-eclampsia
- obstetric cholestasis
- existing diabetes
- IU fetal death
What criteria are assessed in the Bishop score?
- fetal station (0-3)
- cervical position (0-2)
- cervical dilatation (0-3)
- cervical effacement (0-3)
- cervical consistency (0-2)
- 8 or more predicts success
- <8 - cervical ripening needed
What is a balloon and how is it used to induce labour?
- cervical ripening balloon
- silicone balloon is inserted into cervix and gently inflated to dilate it
- used in multiparous women (≥3), prev c-section, vaginal prostaglandin failure
What is a membrane sweep?
- inserting finger into cervix to stimulate and begin labour
- should produce onset within 48hrs
- used from 40 weeks
What is ARM?
- artificial rupture of membranes
- oxytocin infusion
- can be used to progress labour
What are prostaglandins?
- vaginal prostaglandin E2 (dinoprostone)
- inserting gel, tablet or pessary into vagina
- similar to tampon, releases local prostaglandins over 24hrs
- simulates cervix and uterus
How is labour induced in IU fetal death?
- oral mifepristone
- is an anti-progesterone
- plus misoprostol
How is induction of labour monitored?
- CTG for fetal HR and uterine contractions
- Bishop score
What are the criteria for uterine hyperstimulation?
- individual contractions lasting >2 mins in duration
- more than 5 contractions every 10 mins
What is the main complication of induction of labour?
- uterine hyperstimulation
- occurs with vaginal prostaglandins
- prolonged and frequent uterine contraction
- causes fetal distress and compromise
What are the consequences of uterine hyperstimulation?
- fetal compromise > hypoxia and acidosis
- emergency c-section
- uterine rupture
How is uterine hyperstimulation managed?
- removing vaginal prostaglandins
- stopping oxytocin infusion
- Tocolysis with terbutaline
What is cord prolapse?
- umbilical cord descends below presenting part of fetus, through cervix and into vagina after ROM
What is a risk factor for cord prolapse?
- abnormal lie after 37 weeks gestation
- unstable, transverse or oblique
- cephalic: head is in pelvis so no room for cord
How is cord prolapse diagnosed?
- fetal distress on CTG
- vaginal exam
- speculum to confirm
How is cord prolapse managed?
- emergency c-section
- NVD has high risk of cord compression and hypoxia to baby
- minimal handling otherwise vasospasm
What position can be used to manage baby compressing cord prolapse?
- presenting part pushed upwards
- woman lies in left lateral position or knee to chest on all fours
- terbutaline used to minimise contractions
What is the pathophysiology of rhesus?
- rhesus +ve baby’s blood may mix with mother’s
- blood mixes and mother’s body makes antibodies against Rh D antigen
- mother becomes sensitised affecting future pregnancies
What happens if a rhesus negative woman becomes pregnant again?
- anti Rh D antibodies cross placenta
- if placenta is Rh + then haemolysis of RBC occurs
- called haemolytic disease of newborn
How are rhesus negative women managed?
- IM anti-D injections into the women
- attaches itself to Rh D antigens in mother’s circulation
- destroys antigens and prevents mother becoming sensitised to Rh D antigen
When are anti-D injections given?
- 28 weeks
- birth (if baby’s blood is +ve)
- antepartum haemorrhage
- amniocentesis procedures
- abdo trauma
What is the Kleihauer test?
- how much fetal blood has passed into mother’s blood
- used after any sensitising event past 20 weeks gestation
- assesses whether further anti D needed
How does the Kleihauer test work?
- add acid to sample of mother’s blood
- fetal Hb is more resistant so protected from acidosis
- fetal Hb persists, mother’s Hb destroyed
- No of cells remaining is calculated
What is pre-eclampsia?
- new hypertension
- end-organ dysfunction
- proteinuria
When does pre-eclampsia occur and why?
- after 20 weeks
- spiral arteries of placenta form abnormally
- leads to high vascular resistance
Describe the pathophysiology of pre-eclampsia
- high vascular resistance in spiral arteries
- poor perfusion of placenta > oxidative stress
- release of inflammatory chemicals into systemic circulation
- systemic inflammation and impaired endothelial function
What is the triad featured in pre-eclampsia?
- hypertension
- proteinuria
- oedema
What are high-risk factors for pre-eclampsia?
- pre-existing hypertension
- prev hypertension in pregnancy
- existing autoimmune conditions
- diabetes
- CKD
What are moderate risk factors for pre-eclampsia?
- age >40
- BMI >35
- > 10yrs since prev pregnancy
- multiple pregnancy
- first pregnancy
- family history
What prophylaxis is offered for pre-eclampsia and when?
- 75-150mg aspirin from 12 weeks
- one high-risk factor
- two or more moderate-risk factors
What is HELLP syndrome?
- complication of pre-eclampsia and eclampsia
- haemolysis
- elevated liver enzymes
- low platelets
What is eclampsia?
- seizures associated with pre-eclampsia
How is eclampsia treated?
- IV magnesium sulphate
What is chronic hypertension?
- high blood pressure existing before 20 weeks gestation
- not caused by dysfunction in placenta
What is gestational hypertension?
- hypertension occurring after 20 weeks gestation
- without proteinuria
What are the symptoms of pre-eclampsia?
- headache
- visual disturbance/blurriness
- nausea and vomiting
- upper abdo/epigastric pain (liver swelling)
- oedema
- dec urine output
- brisk reflexes
What are the NICE criteria for diagnosis of pre-eclampsia?
- over 140 systolic or 90 diastolic
- PLUS
- proteinuria (1+ or more)
- organ dysfunction
- placental dysfunction
What indicates organ dysfunction in pre-eclampsia?
- raised creatinine
- elevated liver enzymes
- seizures
- thrombocytopenia
- haemolytic anaemia
What values indicate proteinuria in pre-eclampsia?
- protein:creatinine above 30mg/mmol
- albumin:creatinine above 8mg/mmol
What is medical management of pre-eclampsia?
- labetolol (antihypertensive)
- nifedipine
- methyldopa
- IV hydralazine in critical care
- fluid restriction during labour
How is gestational hypertension managed?
- aim for BP below 135/85
- admit if above 160/110
- urine dipstick + bloods weekly
- serial growth scans
- placental growth factor testing
How is pre-eclampsia managed after diagnosed?
- scoring system (fullPIERS or PREP-S)
- BP monitored at least every 48hrs
- USS monitoring of fetus, amniotic fluid and dopplers fortnightly
How is pre-eclampsia managed after delivery?
- BP monitored + returns to normal after placenta delivered
- enalapril
- nifedipine or amlodipine (black patients)
- labetolol
How is delivery managed for pre-eclampsia?
- planned early delivery if BP uncontrolled or complications
- corticosteroids for premature
What are the risk factors for gestational diabetes?
- prev gestational diabetes
- prev macrosomic baby <4.5kg
- BMI >30
- black Caribbean, Middle Eastern, South Asian
- FH of diabetes
What is gestational diabetes?
- diabetes triggered by pregnancy
- reduced insulin sensitivity during pregnancy
- resolves after birth
What complications are there of gestational diabetes?
- large for dates fetus
- macrosomia >shoulder dystocia
- long-term: higher risk of T2DM
When and how is gestational diabetes screened for?
- OGTT
- at booking if prev GD or 24-28 weeks
- large for dates fetus
- polyhydramnios
- glucose on urine dipstick
How is an OGTT performed?
- morning after a fast
- pt drinks 75g glucose
- blood sugar measured before drinking and 2hrs after
What results in an OGTT indicate gestational diabetes?
- fasting ≥5.6mmol/l
- at 2hrs ≥7.8 mmol/l
How is gestational diabetes monitored?
- joint diabetes and antenatal clinic
- dieticians
- monitoring BMs
- 4-weekly USS from 28-36 weeks for fetal growth and amniotic fluid vol
What is the medical management of gestational diabetes?
- fasting glucose <7mmol/l: trial diet and exercise for 1-2 weeks > metformin > insulin
- > 7mmol/l: insulin ± metformin
- > 6mmol/l + macrosomia: insulin ± metformin
What are the blood sugar targets in gestational diabetes?
- fasting: 5.3mmol/l
- 1hr post meal: 7.8mmol/l
- 2hr post meal: 6.4 mmol/l
- avoid levels of 4mmol/l or below
What alternative medication can be used for women declining insulin?
- glibenclamide
- sulfonylurea
- used if not tolerating metformin
How are women with pre-existing diabetes managed in pregnancy?
- 5mg folic acid from preconception - 12 weeks gestation
- aim for same insulin target levels
- metformin ± insulin - other diabetes medications stopped
How is labour altered for women with pre-existing diabetes?
- planned delivery 37-38+6 weeks
- gest diabetes can go up to 40+6
- sliding scale insulin: dextrose and insulin infusion
What screening is done for pre-existing diabetic women in pregnancy?
- retinopathy screening
- shortly after booking and at 28 weeks
- ophthalmologist referral to check for diabetic retinopathy
What happens to gestational diabetes postnatally?
- diabetes improves immediately after birth
- stop diabetic medications
- followup fasting glucose after 6 weeks
- if pre-existing: lower insulin dose and be wary of hypoglycaemia
- insulin sensitivity inc after birth and w breastfeeding
What risks of complications are there for babies of diabetic mothers?
- neonatal hypoglycaemia
- polycythaemia
- jaundice
- congenital heart disease
- cardiomyopathy
How is neonatal hypoglycaemia monitored?
- regular BM checks and frequent feeds
- aim to maintain above 2mmol/l
- If falling below then IV dextrose nasogastrically
What is obstetric cholestasis?
- intrahepatic cholestasis of pregnancy
- reduced outflow of bile acids from liver
What are the causes of obstetric cholestasis?
- resulting from inc oestrogen and progesterone levels
- genetics
- more common in south asians
What is the pathophysiology behind obstetric cholestasis?
- bile acids produced from breakdown of cholesterol
- flow from liver to hepatic ducts, past gallbladder and through bile duct into intestines
- outflow reduced causing buildup in blood
How does obstetric cholestasis present?
- third trimester
- pruritus of palms and soles
- fatigue
- dark urine
- pale, greasy stools
- jaundice
- NO rash
What are differentials for obstetric cholestasis?
- gallstones
- acute fatty liver
- autoimmune hepatitis
- viral hepatitis
What investigations are done for obstetric cholestasis?
- LFTs and bile acids
- abnormal LFTs: ALT, AST, GGT
- raised bile acids
How is obstetric cholestasis managed?
- emollients
- chlorphenamine (antihistamine)
- water-soluble vit K if clotting is deranged
- planned delivery if severely deranged bloods
What complication can occur from obstetric cholestasis?
- stillbirth (intrauterine death)
What is anaemia?
- low concentration of Hb in blood
When are women screened for anaemia in pregnancy?
- booking clinic
- 28 weeks gestation
What is the pathophysiology behind anaemia in pregnancy?
- plasma volume increase in pregnancy
- dec Hb conc
- blood is diluted
- must be treated so woman has reserves if significant blood loss in delivery
How does anaemia in pregnancy present?
- SOB
- fatigue
- dizziness
- pallor
What are the normal ranges for haemoglobin in pregnancy?
- booking bloods: >110g/l
- 28 weeks gestation: > 105g/l
- post partum: 100g/l
What screening for anaemia are women routinely offered at booking clinic?
- haemoglobinopathy screening
- for thalassaemia and sickle cell disease
How is iron deficiency in pregnancy managed?
- iron replacement e.g. ferrous sulphate
- 200mg 3x a day
- if not anaemic but low ferritin > supplementary iron
How is B12 deficiency managed?
- test for pernicious anaemia
- IM hydroxocobalamin
- oral cyanocobalamin
How is folate deficiency managed?
- should already be taking 400mcg/day
- started on 5mg daily
How are thalassaemia and sickle cell anaemia managed?
- managed jointly with specialist haematologist
- high dose folic acid (5mg)
- close monitoring
- transfusions
What is prematurity?
- birth before 37 weeks gestation
- <28 weeks: extreme preterm
- 28-32 weeks: very preterm
- 32-37 weeks: moderate-late preterm
Below what gestation are pregnancies considered non-viable?
- non-viable <23 weeks
- 23 weeks = 10% chance of survival
- > 24 weeks = inc chance and full resus offered
What is tocolysis?
- medication to stop uterine contractions
- nifedipine (CCB)
- used 24 - 33+6 weeks gestation
Why is tocolysis used?
- delays delivery
- allows for fetal development, maternal steroids or transfer to specialist unit
What is an alternative tocolytic?
- atosiban
- oxytocin receptor antagonist
What antenatal steroids are given and why?
- 2 doses IM betamethasone
- develop fetal lungs
- reduce resp distress syndrome
- used in suspected preterm labour <36 weeks gestation
Why is magnesium sulphate used?
- IV
- protects fetal brain in premature delivery
- reduces risk and severity of cerebral palsy
When is magnesium sulphate given?
- within 24hrs of delivery of preterm babies
- <24 weeks gestation
What are key signs of magnesium toxicity?
- 4hrly obs
- reduced RR
- reduced BP
- absent reflexes
How does vaginal progesterone prevent preterm labour?
- gel or pessary
- maintains pregnancy and decreases myometrial activity
- prevents cervical remodelling
What is P-PROM?
- preterm prelabour ROM
- amniotic sac ruptures before labour and in preterm pregnancy
How is P-PROM diagnosed?
- speculum for pooling of amniotic fluid in vagina
- IGFBP-1 testing
- PAMG-1 testing
How is P-PROM managed?
- prophylactic Abx to prevent chorioamionitis
- erythromycin 250mg QDS for 10 days
- induction of labour offered from 34 weeks
What is placenta accreta?
- placenta implants deep
- through and past endometrium
- difficult to separate placenta after baby delivered
What is superficial placenta accreta?
- placenta implants in surface of myometrium
What is placenta increta?
- placenta attaches deeply into myometrium
What is placenta percreta?
- placenta invades past myometrium, reaching other organs
Where does the placenta usually attach?
- to the endometrium
What are risk factors for placenta accreta?
- previous accreta
- previous endometrial curettage
- previous C-section
- multigravida
- increased maternal age
- low-lying/placenta praevia
How is abortion accessed?
- self-referral, GP, GUM or family planning clinic
- doctors who object should pass on the referral
Which 2 acts constitute the legal framework for an abortion?
- 1967 abortion act
- 1990 human fertilisation and embryology act
What does the 1990 HFEA act say?
- expanded the criteria for abortion
- reduced latest age from 28 to 24 weeks
What are the criteria for abortion before 24 weeks?
- continuing pregnancy involves greater risk to physical or mental health of the woman or existing children of the family
- threshold is a matter of clinical judgement
Which factors allow an abortion to be performed after 24 weeks?
- continuing pregnancy risks woman’s life
- terminating prevents ‘grave permanent injury’ to woman
- substantial risk that the child would suffer physical/mental abnormalities > severe handicap
What are the legal requirements for abortion (who agrees/carries it out)?
- 2 registered medical practitioners must sign to agree
- must be carried out by registered medical practitioner in an NHS hospital or approved premise
Which symptoms may be experienced post-abortion?
- vaginal bleeding
- abdominal cramps for up to 2 weeks
- UPT performed 3 weeks after to confirm complete
What are the treatments used in a medical abortion?
- mifepristone
- misoprostol 1-2 days later
- additional misoprostol doses every 3hrs until expulsion
What is the action of mifepristone?
- anti-progestogen
- blocks action of progesterone
- halts pregnancy
- relaxes cervix
What is the action of misoprostol?
- prostaglandin analogue
- activates receptors
- softens cervix
- stimulates uterine contractions
What types of anaesthetic are used in surgical abortion?
- local
- local + sedation
- general
What are complications of an abortion?
- bleeding
- pain
- infection
- failure of abortion
- damage to cervix, uterus or other structures
Which medications are used prior to surgical abortion?
- cervical priming
- misoprostol
- mifepristone
- osmotic dilators
What are the options for surgical abortion?
- cervical dilatation and suction of contents (<14 weeks)
- cervical dilatation and evacuation with forceps (14-24 weeks)
How are pregnant women protected against chickenpox?
- if not immune: given varicella zoster immunoglobulins
- protection post exposure
What is the risk of chickenpox in pregnancy before 28 weeks?
- developmental problems in fetus
- congenital varicella syndrome
What is the risk of chickenpox during delivery?
- can lead to neonatal infection
- treated with VZ immunoglobulins and Aciclovir