Obstetrics Flashcards
What times should female hormone testing be done for fertility during her cycle
Serum LH and FSH on days 2-5
Serum progesterone on day 21 or 7 days before the end of the cycle
Anti-mullerian hormone - low level = low ovarian reserve
Thyroid function
Prolactin
What are the pre-testicular causes of infertility
Hypogonadotrophic hypogonadism- low LH and FSH causing low testosterone
Pituitary or hypothalamus issues
Suppression due to stress
Kallman syndrome(delay/ absent puberty with no smell)
What are some testicular causes of infertility
Mumps
Undescended testes
Trauma
Radiotherapy
Chemotherapy
Cancer
What investigations are done for a pregnancy of unknown location?
Serum hCG monitored over time- repeated after 48 hrs
Rise of over 63%- indicates intrauterine pregnancy- repeat USS in 1-2 weeks
Rise of less than 63%- ectopic pregnancy
Fall of more than 50%- miscarriage- pregnancy test again in 2 weeks
What is the criteria for management with methotrexate for an ectopic
-HCG level <5000 IU/L
-Confirmed absence of intrauterine pregnancy
-Follow up needed
-Ectopic mass enraptured
-Adenexal mass<35mm
-No visible heart beat
-No significant pain
How is methotrexate given in Ectopics
IM into bum
Can’t get pregnant for 3 months after
What is the surgical management for an ectopic and when is it used
Done if
-Pain -Adnexal mass>35mm -Visible heart beat -HCG>5000 IU
Can be laparoscopic salpingectomy- first line- removing affected tube
Laparoscopic salpinotomy- avoid removing the tube but remove the ectopic
Anti-D propylaxis is given to Rh -ve women
What are the USS findings in keeping with a miscarriage
CRL is >7mm but no fetal heart beat is found
Repeat this scan in one week to confirm miscarriage
What is the management of a patient less than 6 weeks with vaginal bleeding
Expectant - waiting - USS not helpful here as cannot see Heart beat anyway
Repeat pregnancy test 7-10 days and if negative miscarriage confirmed
What is the management of a patient more than 6 weeks with vaginal bleeding
Refer to early pregnancy
Transvaginal USS
Expectant management
If no risk factors or infection- give 1-2 weeks for miscarriage to occur
Medical
Misoprostal as a vaginal suppository or an oral dose
Surgical
Misoprostal given before
Manual vacuum aspiration - need to be less than 10 weeks
Electric vacuum aspiration
Anti-D given if rhesus positive
How is an incomplete miscarriage managed
Medical - misoprostal
Surgical- evacuation of retained products of conception
What is antiphospholipid syndrome
Antiphospholipid antibodies make the body prone to clotting - hyper coagulable state
Autoimmune condition can be secondary to SLE
Multiple miscarriage and DVT history
Treatment with aspirin and LMWH (enoxaparin)
What hereditary thrombophilias can cause miscarriage
Factor V leiden (most common)
Factor II (prothrombin) gene mutation
Protein S deficiency
When can an abortion before 24 weeks be carried out/ at any time
If continuing pregnancy is greater risk to physical or mental health or mum or baby
Abortion at any time if continuing will risk the woman’s life or substantial risk of physical/ mental abnormalities of child
What is used in medical abortion
Mifepristone- anti progesterone to halt pregnancy and relax cervix
Misoprostol- prostaglandin analogue to stimulate uterine contractions - from 10 weeks onwards additional misoprostal doses are added- every 3 hrs till explosion
Urine pregnancy test 3 weeks after to confirm
What are the two surgical abortion options
Cervical dilation and suction of contents up to 14 weeks
Cervical dilation and evacuation from 14-24 weeks
What is the criteria for hyperemesis gravidarum
-More than 5% weight loss compared with before pregnancy
-Dehydration
-Electrolyte imbalance
PUQE score will give score out of 15
<7- mild
>12- Severe
How is hyperemesis gravidarum management
Antiemetics
1. Prochlorperzine
2. Cyclizine
3. Ondansetron
4. Metoclopramide
Can use omeprazole if acid reflux
Consider admission if
Can’t take oral tablets/ keep anything down
Ketones in urine
>5% weight loss
How do you manage severe hyperemesis gravid arum
IV/IM antiemetics
IV fluids - Normal saline and K
Daily U&Es
Thiamine supplementation
Thromboprophylaxis
What is a complete mole
When two sperm cells fertilise an egg that has no genetic material - sperm combine genetic material
What is a partial mole
Two sperm cells fertilise a normal ovum at once and the ovum has 3 sets of chromosomes - some fetal material may form
What are the symptoms of molar pregnancy
-Severe morning sickness
-Vaginal bleeding
-Increased enlargement of uterus
-Abnormally high bHCG
-Thyrotoxicosis (HCG can mimic TSH and stimulate thyroid)
USS will show snowstorm appearance
How is a molar pregnancy managed
-Evacuation of uterus and histological examination
HCG levels monitored until normal
What does gravida and para mean
Gravida- number of pregnancies
Para- number of times a woman has given birth past 24 weeks
What vaccines should a pregnant woman get
Whooping cough (Pertussis) from 16 weeks
Influenza (flu)
Avoid live vaccines (MMR)
What lifestyle advice is given to a pregnant woman
-Folic acid 400mg
-Vitamin D (10mcg)
-Avoid vit A
-No alcohol
-No smoking
What screening is done at booking
-Blood group, antibodies, Rhesus
-FBC (Anaemia)
-Thalassaemia/ sickle cell
-HIV, hep B, syphillis
-Urine- protein and bacteria
-BP
Risk assessment
-RH -ve
-Gestational diabetes
-FGR
-VTE (give enoxaparin if high risk)
-Pre-eclampsia (give aspirin if high risk)
How is hypothyroidism treated in pregnancy
Levothyroxine needs to be increased during pregnancy by 25-50mcg
As it can cross the placenta
How is hypertension treated in pregnancy
ACE, ARB and thiazide diuretics STOPPED
Labetalol used
CCBs (nifedipine) can be used
Alpha blockers can be used (Doxazosin)
How is epilepsy treated in pregnancy
Epilepsy should be controlled on a single anti-epileptic before pregnancy
Levetriacetam, lamotrigine and carbamazepine- safer in pregnancy
Sodium valproate avoided- neural tube
Phenytoin avoided- cleft lip/palate
How is rheumatoid arthritis treated in pregnancy
Methotrexate contraindicated
Hydroxychloroquine- safe and first line
Sufasalazine - safe
Can use steroids in flare ups
What medications should be avoided in pregnancy
NSAIDs- block prostaglandins - esp in 3rd trimester can cause premature closure of ductus arteriosus - also delay labour
Beta blockers- can use labetalol - FGR, Hypoglycaemia and bradycardia in neonate
ACE and ARB- affect foetal kidneys
Opiates- fetal withdrawn
Warfarin- fetal loss/ malformations
Sodium val- teratogenic neural tube
Lithium- congenital cardiac abnormalities
SSRI’s -Congenital heart defects and withdrawal
Roaccutane- teratogenic
What infections must be avoided in pregnancy
Rubella- maternal infection before 20 weeks - congenital deafness, cataracts, heart disease, learning disability
Chickenpox- fetal varicella syndrome, more severe infection in mother
Exposure to chicken pox - if woman has had chickenpox- safe
If they are not sure- immunity tested and if IgG levels positive- safe
If not immune treat with IV varicella immunoglobulins within 10 days
Listeria - unpasteurised dairy products
CMV/ Congenital toxoplasmosis- this will cause hearing loss, low birth weight, petechial rash, microcephaly and seizure- hepatosplenomegaly
Parovirus B19 - Slapped cheek - miscarriage, hydrops fetalis, maternal preeclampsia
Women with suspected infection
IgM- acute infection
IgG - previous immunity
Rubella antibodies
Zika virus
When are anti-D injections given and what is their purpose
28 weeks and then at birth if baby is rhesus positive
Also given in
Antepartum haemorrhage, amniocentesis and abdo trauma
Kleinhauer test shows how much fetal blood passed into mother circulation
Anti-D injection will destroy foetal RBC to prevent mother’s immune system making her own antibodies against the antigen
What are the risk factors for Small gestational age
Previous SGA baby
Obesity, smoking, diabetes, exisiting HTN, pre-eclampsia, mother over 36, multiple pregnancies, antepartum haemorrhage, antiphospholipid synd
What is the management for a foetus that is SGA
Low risk women- symphysis fundal height measured from 24 weeks
High risk women- serial growth scans with umbilical artery doppler and amniotic fluid volume
Identify underlying cause
When growth is static on growth chart- early delivery with corticosteroids and planned C-section
What are the causes and risks associated with a baby that is LGA. What is the management
Causes: Constitutional, maternal diabetes, macrosomia, maternal obesity/ rapid weight gain, overdue, male baby
Risks: Shoulder dystocia, failure to progress, perineal tears, instrumental/Csection, postpartum haemorrhage, uterine rupture
Neonatal hypoglycaemia, obesity in childhood, type 2 diabetes in adulthood
Management: USS to exclude polyhydraminos, OGTT for gest Diabetes
What is the management of a UTI in pregnancy
7 days of nitrofurantoin 1st and 2nd trimester
Amoxicillin or cefalexin
Avoid trimethoprim in first semester - folate antagonist
What is the management for anaemia in pregnancy
Iron supplementation - ferrous sulphate 200mg 3x daily
B12 deficiency - test for pernicious anaemia (intrinsic factor antibodies), Give IM hydroxycobalamin or oral cyanocobalamin
Folate deficiency- folic acid 5mg
When is VTE prophylaxis given to a pregnant woman
at 28 weeks if there are 3 risk factors
First trimester if there are four or more risk factors
Given enoxaparin
Risk factors- smoking, parity >3, over 35, BMI>30, low mobility, pre-eclampsia, varicose veins, fam history, thrombophilia, IVF