Obs & Gynae Flashcards
how many hrs post LH surge does ovulation occur
24-36h
proliferative phase of uterine cycle runs alongside what part of the menstrual cycle
follicular phase
secretory phase of the uterine cycle runs alongside what part of the menstrual cycle
luteal phase
normal menstrual loss
10-80ml
metorrhagia
intermenstrual bleeding
amenorrhoea
absence periods >6m
oligomenorrhoea
intervals > 35d
Mx DUB
- Mirena IUS
cOCP
POP
Non-hormonal - Tranexamic acid
normal vaginal pH
3-4
bacteria causing BV
gardnerella vaginosis
Ix BV
clinical Dx
or
HVS
clue cells on microscopy
BV
Mx vaginal candida if preg
only Topical Mx
no oral fluconazole
what is trichomonas vaginalis
PARASITE (got this wrong in CAP)
presentation trichomonas
strawberry cervix
musty smelling
frothy discharge
Ix trichomonas vaginalis
HVS
cause of chlamydia
chlamydia trachomatis
presentation chlamydia
asymptomatic (70% women, 50% men)
or
urethritis (M), discharge (F)
Ix chlamydia
F - endocervical swab
M - first pass urine
for PCR/NAAT (always do gonorrhea test too)
why is PCR/NAAT the test for chlamydia
chlamydia doesn’t stain with gram stain
Mx chlamydia
either:
doxycycline 7d
or
azithromycin 1g oral single dose
both are 1st line, using doxy more now
Ix gonorrhoea
F - endocervical swab
M - first pass urine
for PCR/NAAT (always do chlamydia test too)
disadvantage of PCR/NAAT
doesn’t give sensitivities
what is gonorrhoea
gram negative diplococcus
cause of syphilis
treponema pallidum
shape of syphilis
spirochaete
stages of syphilis
- painless chancre
- “the great imitator” - lymphadenopathy, rash on palms, soles, trunk
- gummas - small lesions on skin and bones, cardio + neuro complications
Ix syphilis
swab for dark ground microscopy
Screening: ELISA test (combined IgM and IgG)
TPPA: specific
VDRL: non-specific, used for monitoring
Mx syphilis
IM penicillin
HPV causing genital warts
6+11
Mx genital warts
- solitary - cryotherapy, multiple - podophyllotoxin cream
2. Imiquimod (aldara)
Ix genital herpes
swab of ulcer for PCR
Mx pubic lice (crabs)
malathion lotion
RF for endometrial Ca
obesity
unopposed oestrogen
nulliparity
protective factors for endometrial Ca
smoking
combined pill
genetic predisposition to endometrial Ca
Lynch syndrome
- autosomal dominant
- also colon ca
Mx endometrial Ca
total hysterectomy + bilateral salpingo-oophrectomy
presentation fibroids
bulky uterus
menorrhagia
subfertility
Ix fibroids
TVUs
Mx fibroids if fertility desired
Medical:
leuprorelin (GHRH agonist)
IUS
Surgical:
myomectomy
Mx fibroids if fertility not desired
Endometrial ablation
Uterine artery embolization
Hysterectomy
complication of fibroids
red degeneration:
haemorrhage into the tumour, most commonly happens in pregnancy
what is adenomyosis
presence of endometrial tissue in the myometrium
presentation adenomyosis
menorrhagia
dysmenorrhea
boggy, tender uterus
Mx adenomyosis
Hormonal Tx:
GNRH agonists, POP, Mirena, COC
Only definitive Tx: hysterectomy
presentation endometriosis
cyclical abdo pain dyspareunia dysmenorrhea menorrhagia subfertility
Ix endometriosis
laparoscopy
Mx endometriosis
cOCP, IUS
laser ablation
cOCP and increased discharge - Dx?
ectropion
meigs syndrome
adenoma + ascites + pleural effusion
HPV types cervical Ca
16 & 18
if a womas has symp suspicious of cervical Ca - Ix?
straight for colposcopy
smear shows mild dyskaryosis - what do you do
rpt smear 6m
smear shows moderate dyskaryosis - what do you do
refer colposcopy
smear shows severe dyskaryoisis - what do you do
urgent refer colposcopy
Mx CIN 1
observe
Mx CIN II
LLETZ
Mx CIN III
LLETZ
woman has had Tx for CIN - what do you do next
rpt smear and HPV test in 6m
- if -ve, go back to routine recall every 3y
if +ve, another colposcopy and follow up yrly for 5y
presentation of cervical ca
abnormal bleeding
- post-coital
- post-menopausal
- brownish or blood stained discharge
- contact bleeding
Mx cervical ca
radical hysterectomy
+
radiotherapy/chemotherapy
radical hysterectomy
removal of uterus, cervix and upper vag
hysterectomy
removal of uterus and cervix
cell type of cervical ca
SCC
risk factors ovarian ca
nulliparity
many cycles (early menarche, late menopause)
BRCA 1 and 2
increased age
protective factors for ovarian ca
COC pill
ovarian tumours arising from serous epithelium
serous
endometroid
mucinoid
clear cell
ovarian tumours arising from germ cells
teratoma (dermoid cyst) - BENIGN
choriocarcinoma
yolk sac - MALIGNANT
ovarian tumours arising from stroma
these are the hormone secreting tumours
granulosa - oestrogen
theca - androgen
fibroma (benign) - meig’s syndrome
most common cancers to mets to ovary
breast
pancreas
stomach
GI
tumour marker ovarian ca
CA125
Ix ovarian Ca
- CA125
- USS/CT
- CEA (to exclude GI primary)
risk of malignany index - ovarian Ca
menopausal status x US score x CA125
RMI > 250, refer to gynae
Mx ovarian ca
total hysterectomy + bilateral salpingoophrectomy + omental removal
chemo
pathophysiology of PCOS
Excess LH
- stimulates over production of androgens
and
Insulin Resistance
- suppresses hepatic production of SHBG which increase amount of circulating free androgens
presentation PCOS
oligomenorrhoea or amenorrhoea
hirsutism or acne
obesity
insulin resistance
Rotterdam criteria
must meet 2/3 for Dx of PCOS:
1 .oligo- or amenorrhoea
- clinical or biochemical signs of ++ androgens
- polycystic ovaries on US
Mx PCOS
- wt loss, metformin
- if pt doesn’t desire pregnancy: OCP, dianette
- if pt does want pregnancy: clomifene +/- metformin
- for hirsutism: eflornithine cream/laser
location of Bartholin’s glands
4 and 8 oclock positions
- deep to the posterior aspect of the labia majora
difference in presentation of Bartholin’s cyst and Bartholin’s abscess
cyst - soft, fluctuant, non-tender
abscess - hard, non-fluctuant, tender, surrounding cellulitis
Mx Bartholin’s cyst or abscess
marsupialisation
lichen sclerosis presentation
atrophic white patches
itch
fusion of clitoral hood, vaginal opening
Mx lichen sclerosis
topical steroids
Mx urge incontinence
reduce caffeine/alcohol
bladder training
muscarinic antagonists - oxybutynin, solifenacin, tolteridine
oestrogen pessary
Mx stress incontinence
lifestyle changes
pelvic floor training
duloxetine
rarely surgery
urethrocele
prolapse: urethra into vagina
rectocele
prolapse: rectum into vagina
enterocele
prolapse: small bowel into vagina
cystocele
prolapse: bladder into vagina
Mx of prolapse if incidental finding
pelvic floor work
Mx prolapse if old lady, multi morbidity and procidentia
pessary
grades of uterine prolapse
- into vagina
- at vaginal orifice
- outside vagina
- procidentia - entirely outside vagina
vaginal vault
vaginal prolapse
Mx vaginal vault prolapse
sacrospinous fixation
or
hysterectomy
what cancers does cOCP increase risk of
breast
cervical
what cancers does cOCP decrease risk of
endometrial
ovarian
UKMEC4 for cOCP
>35 and smoking >15/day uncontrolled HTN migraine with aura Hx of VTE/stroke/IHD breast ca breastfeeding and <6w post-partum
mode of action of cOCP
inhibits ovulation
effect of epilepsy medicines on cOCP
reduce function of cOCP, as they are CytP450 inducers,
mode of action of POP
thickens cervical mucus
how many hrs is the window for a missed POP
3h
if missed POP pill >3h ago - what do you do
take asap and advise condom using until pill-taking been re-established for 48h
mode of action of implant
inhibits ovulation
mode of action of IUS
prevents endometrial proliferation/implantation
s/e of IUD
heavier periods
s/e of depo
prolonged return of fertility
increases appetite
mode of action of depo
inhibits ovulation
premature menopause
<40y
early menopause
<45y
late menopause
> 54 y
criteria for menopause
> 1y amenorrhoea
FSH >30 IU/L
who gets oestrogen only HRT
post-menopausal women
NO UTERUS
who gets combined sequential HRT
any of: peri-menopausal women <54y <1y amenorrhoea and WITH A UTERUS