Common drug side effects Flashcards
s/e of phenytoin
acne
coarse face
gum hypertrophy
hirsutism
how does phenytoin toxicity present
as a cerebellar syndrome
s/e of sodium valproate
‘valproate’
Valproate Appetite increase (wt gain) Liver failure (monitor LFTs during 1st 6m) Pancreatitis Reversible hair loss Oedema Ataxia Teratogenicity, Tremor, Thrombocytopenia Encephalopathy
s/e of lamotrigine
rash (SJS)
s/e of SSRI
nausea low libido withdrawal insomnia hyponatraemia
s/e of TCAs
anti-cholinergic effects: dilated pupils, blurred vision, dry mouth, flushed skin, urinary retention
arrhythmias
s/e of MAOIs
3H’s
hypertension
hepatocellular jaundice
hyperthermia
s/e of ACEi
dry cough
postural hypotension
renal failure in renal artery stenosis (check U&Es 2w before starting)
hyperkalaemia
s/e of B-blocker
diabetes risk
impotence
cold hands and feet
s/e of all diuretics
dehydration hyperuricaemia hypokalaemia (except K sparing) hyponatraemia hypomagnesaemia
s/e of loop diuretics
hypocalcaemia
s/e of thiazide diuretics
hypercalcaemia
s/e of sulfasalazine
myelosuppression oligospermia hepatitis rashes renal problems discoloured urine
s/e of gold
skin discolouration nephrotic sydnroem myelosuppression eryhtroderma thrombocytopenia
s/e of penicillamine
nephrotic syndrome
myelosuppression
s/e of chloroqine
retinopahty
tinnitus
myopathy
s/e of TNF antagonists
infection - TB reactivation
autoimmune reactions
s/e of cyclophosphamide
haemorrhagic cystitis
myelosuppression
alopecia
s/e of chlorpromazine
cholestatic jaundice
s/e of haloperidol
prolonged QT interval
s/e of amiodarone
thyroiditis pulmoanry fibrosis peripheral neuropathy myopathy blue-grey skin pigmentation hepatitis metallic taste int mouth
digoxin toxicity
yellow vision
GI distress
any arrhythmia
s/e of adenosinw
flushing
sense of impending doom
drugs causing hypokalaemi
salbutamol
insulin
diuretics
caffeine/theophylline
drugs causing hypercalcaemia
thiazide diuretics
drugs causing acute interstitial nephritis
NSAIDs
penicillins/cephalosporins
drugs causing acute tubular necrosis
lithium
contrast
gentamicin
amphotericin B
main drug class causing photosensitivity
tetracyclines
drugs causing gynaecomastia
‘DISCO MTV’
Digoxin Isoniazid Spironolactone Cimetidine Oestrogens Methyldopa TCAs Verapamil
s/e of lithium
diarrhoea
hypothyroidism
diabetes insipidus
worsens psoriasis
signs of lithium toxicity
tremor/ataxia/dysarthria -
leading to convulsions, coma and hypotension
