Obs Flashcards

1
Q

What are the classifications of placenta accreta spectrum?

A

Placenta accreta – invasion of placenta beyond decidua basalis, not into myometrium

Placenta increta – invasion of placenta beyond endometrium into myometrium

Placenta percreta – invasion of placenta into serosa +/- invasion into surrounding organs e.g. bladder

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2
Q

What are risk factors for placenta accreta spectrum?

A
Previous CS  (RR 4.5, >/= 4CS RR 45)
Previous uterine surgery - STOP, MROP, Curette, 
Previous accreta
Previous placenta praevia
AMA
Multiparity
Smoking
ART
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3
Q

Name 11 USS features of placenta accreta

A
  1. Loss of hypo-echoic retroplacental clear zone
  2. Placental lacunae
  3. Abnormal myometrial/bladder interface
  4. Thinning <1mm or absence of myometrium beneath placenta
  5. Focal bulge of serosa
  6. Exophytic mass
  7. Hypervascularity between uterus/bladder
  8. Subplacental hypervascularity
  9. Bridging vessels from placenta across myometrium
  10. Placental lacunae feeding vessels
  11. Parametrial involvement
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4
Q

Management of placenta accreta spectrum

A

High level of diagnostic suspicion
MDT with tertiary centre input
Stay near to centre
Hb optimisation
MRI for operative planning - NOT diagnosis
Planned early delivery by caesarean section - RANZCOG does not given definite time (RCOG says 35-36+6). Alter if RFs for preterm birth.
Consider antenatal corticosteroids
Consent ahead of time including need for RBC transfusion, hysterectomy, higher risk renal tract injury
Have valid G&H, be prepared to activate MTP
Consider usage of cell saver
Aim regional anaesthesia - consider CSE
Delivery options
- CS, lower segment, attempt delivery of placenta, prepare for hysterectomy if not
- CS with incision away from placenta, delivery, closure of uterotomy and hysterectomy
- CS with incision away from placenta, delivery, trim short placenta cord and closure. Manage conservatively and/or plan hysterectomy at a later date
- CS with incision away from placenta, delivery, partial resection of uterine wall and repair
Conservative treatment - HIGH risk of infection, later emergency hysterectomy
Avoid ecbolic if not planning to separate placenta
Consider ureteric stents if percreta involving bladder, not routinely

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5
Q

What is the differential diagnosis for fetal hydrops?

A
Fetal anaemia
- Immune haemolytic disease
- parvovirus
- FMH
- Alpha thalassaemia - HbH
Fetal infection
- CMV
- Toxoplasmosis
- Syphilis
- Parvovirus (as aboev)
Fetal cardiac anomaly
Metabolic
Aneuploidy e.g. Turner's syndrome
TTTS
Fetal chylothorax
Idopathic
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6
Q

What are classes of obesity in pregnancy?

A

Obese Class I BMI 30-34.9

Obese Class II BMI 35-39.9

Obese Class III BMI >40

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7
Q

List complications associated with obesity in pregnancy

A

Fertility delay

Miscarriage

Fetal anomaly, neural tube defects

Excessive gestational weight gain

Gestational diabetes

Fetal macrosomia

Pregnancy induced hypertension and pre-eclampsia

Undetected intrauterine growth restriction - Limited fundal palpations – more reliant on USS for fetal growth surveillance

Preterm birth

Stillbirth

Venous thromboembolism

Labour dystocia

Shoulder dystocia

Post partum haemorrhage

Assisted vaginal birth

Caesarean section and emergency caesarean (and associated complications all higher – bleeding, infection, injury to viscera)

If obesity hypoventilation and sleep apnoea – chronic intrauterine hypoxia

More complicated anaesthesia – epidural and spinal difficult insertion, higher rate of aspiration with GA

Higher ICU admission

Lower breastfeeding

Infant more likely to become obese

Higher rate of maternal death

Higher obstructive sleep apnoea

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8
Q

What are the benefits of IOL before 39weeks for suspected fetal macrosomia?

A

Less shoulder dystocia - RR 0.6
Less boney fracture - RR 0.2, NNT 60
No change in CS birth
No change in assisted vaginal birth

BUT

No significant differences in brachial plexus injury (although very infrequent finding)

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9
Q

What are recommended measures to prevent fetal macrosomia?

A

Regular exercise - aerobic and strengthening, as long as not contra-indicated

Maintenance of near-normal BSLs in diabetic mothers

Pre-pregnancy weight optimisation, recommend discussion re bariatric surgery if class III obesity

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10
Q

What is the definition of GDM?

A

Evidence of impaired glucose tolerance first diagnosed or developed in pregnancy

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11
Q

What are the WHO 10 steps of breastfeeding?

A
  1. Have a written policy
  2. Train staff to have skills to implement policy
  3. Inform women about benefits
  4. Help mothers breastfeed within 30mins of birth
  5. Show mothers how to breastfeed and how to maintain this
  6. Don’t offer any alternatives unless indicated
  7. Practise rooming in
  8. Encourage breastfeeding on demand
  9. Give no artificial teats or pacifiers
  10. Foster support groups and refer mothers to them
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12
Q

What are advantages to breastfeeding?

A

Neonatal/paediatric:
↓ Reflux, respiratory illness, otitis media, SIDS, atopy, UTIs, T1 and T2DM, obesity
Effective pain relief for minor procedures

Maternal:
↓ ovarian and breast ca risk
↓ PPH as involutes faster
Lower cost
Provides amenorrhoea and contraception
↑ bonding
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13
Q

How are preterm births classified?

A

Gestation Classification Frequency
34-36 weeks Late preterm 32-36weeks 84% preterm births
32-34+ weeks Moderate preterm <34weeks 3% all births Aus
28-32weeks Very preterm 10% preterm births, <32weeks 1.2% all births NZ
<28weeks Extremely preterm 5% preterm births, 0.5% all births in NZ

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14
Q

What is the definition of a live birth?

A

Expulsion from the mother at any gestation and after separation shows signs of life - breathing, heart beating, definite movement of voluntary muscle, cord pulsating

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15
Q

What is the definition of a miscarriage?

A

Loss of a pregnancy <20weeks

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16
Q

What is the definition of a stillbirth?

A

Birth of a baby with no signs of life >/= 20weeks gestation or >/= 400g if gestation unknown

17
Q

What is the definition of neonatal mortality?

A

Death of a live-born baby from birth until midnight on 27th day of life

18
Q

What is the definition of perinatal mortality?

What is the rate in Aus/NZ?

A

Any loss of life from 20weeks until midnight 27th day of life (stillbirth and neonatal mortality)
(NZ go until midnight on 6th day of life)

Rate is per 1000 births

NZ 10/1000 = 1%
Australia 9.6/1000

19
Q

How is maternal morbidity defined?

A

Any short- or long-term outcome that results from pregnancy or birth with negative outcome on woman’s wellbeing

20
Q

Benefits of early epidural in women with PET

A

Reduces pre and afterload - BP treatment in labour
Adequate analgesia
Avoids fluctuations in BP if GA and intubation needed - also airway oedema so GA higher risk
Quicker block if OT needed in a hurry
May also improve renal and placental flow

21
Q

MSS1

A

Combined FTS 11+0 - 13+6/40
Serum - PAPP-A, BhCG
USS - NT if >3mm higher assoc with aneuploidy

Provides risk assessment for T21, T13, T18

Sensitivity 85%
Specificity 95%
PPV depends on maternal age - higher if >35y (as higher prevalence in this population)

Benefits:
Non-invasive - no miscarriage risk from the test
Screen at relatively early gestation, if leads to TOP earlier gestation makes safer
Biomarkers provide risk for IUGR, PET
Early USS - may show up to 50% of major anomalies, identify multiple pregnancy, confirm gestation, diagnose missed miscarriage
Performs well in an at-risk population
More accurate than MSS2

Disadvantages:
Resource dependent - bloods and skilled ultrasonographer
Time critical - some may not have booked yet
Detection of affected pregnancy that may have gone on to spontaneously miscarry (15% of T21 at 11-16weeks)
False positive may cause high anxiety, may affect screening participation in a future pregnancy
Need for invasive test to confirm - risks associated with this, potential for normal pregnancy to miscarry
Costs to the patient may vary

22
Q

MSS2

A

Second trimester 15-20weeks
Serum - BhCG, AFP, Oestradiol, Inhibin A

Sensitivity 75%
Specificity 95%
PPV 3%

Benefits:
Non invasive
Easy to perform as single blood test
Suitable screening if pregnancy diagnosed/booked late
Performs better in a higher risk population
Biomarkers e.g. AFP can also provide a clue of other structural abnormalities if very high e.g. NTD

Disadvantages:
Less accurate than MSS1
Later gestation, if truely abnormal and TOP planned this may be getting close to viability
Not suitable for multiples as biomarkers confound
Biomarkers affected by other factors - IVF, weight, smoking
Relies on invasive test to confirm - could lead to healthy pregnancy miscarrying
Does not provide structural assessment of baby, confirm gestation, viability, multiple or not

23
Q

T21

A

1: 400 pregnancies
1: 1000 livebirths

Increasing maternal age is biggest predictor

1: 1000 at term if 30
1: 300 at term if 35
1: 100 at term if 40

Biomarkers: 
Low PAPP-A
High BhCG
Low inhibin-A
Low oestradiol

Features:
Wide nasal bridge, epicanthal folds, brachycephaly, webbed neck, upward slanting eyes, single palmar crease

Complications:
Cardiac defects, duodenal atresia, epilepsy, dementia, hypothyroidism, leukaemia, immune deficiency, intellectual impairment

Recurrence risk 1:100

24
Q

Parvovirus

A

Single stranded DNA virus
Transmitted respiratory secretions, hand to mouth
Targets P antigen on fetal RBCs and erythrocyte precursors. Leads to haemolytic anaemia and sometimes hydrops, fetal death.
Higher risks are infection <20weeks as erythropoiesis in liver and at most rapid.

50% risk fetal infection

  • asymptomatic - most likely
  • fetal anaemia - usually self limited
  • fetal hydrops ~3%, average onset 5weeks post infection
  • miscarriage 10% extra if <20weeks

Management:
Counsel about exposure risks
Offer serological testing (IgM, IgG +/- avidity)
No specific intervention to prevent or treat
Do not offer TOP - risk of adverse fetal outcome is low
USS 1-2weekly for 12 weeks - MCA PSV (>1.5MoM suggests anaemia), hydrops
Refer to FMed if signs of anaemia/hydrops - fetal blood sampling +/- IUT
FMed to confirm fetal infection if signs – Amnio and PCR (not if normal USS)
Normal cares if no anaemia - no evidence of longterm sequalae

Prevention
No vaccine
Hand hygiene
No need to stay at home in pandemic

25
Q

NIPT

A

Cell free fetal DNA from the placenta in maternal blood, does not last for long so is specific to this pregnancy
Perform reliably from 10weeks gestation
Screens for trisomy 21, 18, 13 and sex chromosomes (optional)
Massive parallel or shotgun sequencing, selective chromosomal analysis - detects proportion of T21 and reports if disproportionate.
Still is a screening test - provides a risk that if high risk would require an invasive test to confirm.
Requires sufficient fetal fraction. Low with: high BMI, multiples, IVF, early gestation, maternal LMWH, fetal aneuploidy.
Potential for no result 1-6% - low fetal, fraction, variance, assay failure. Maternal aneuploidy, maternal malignancy, fetal aneuploidy,

Benefits:
Non-invasive
Overall sensitivity of T21 is >99% and specificity 99%
More accurate so limits the normal pregnancies that have invasive procedures and miscarry
Informs re sex chromosomes - gender, implications for sex-linked genetic disorders, sex chromosomal disorders
May be used for single gene disorders and fetal Rh genotyping
Performs best in an at-risk population - useful 2nd screen if CFTS/MSS2 is high risk
Doesn’t require USS resource or skills of a sonographer
More flexibility about timing can be performed

Limitations:
Not funded - costs ~$650 - barrier to access for many
Still recommended to have 12-13/40 anatomy USS as can detect 50% of major anomalies
Doesn’t provide PAPP-A and risk stratification
Failure rate or inconclusive - these pregnancies carry a higher risk of aneuploidy
Result turn around 7-10days

26
Q

Cardiac disease - factors affecting pregnancy tolerance

A

Presence of pulmonary HTN: poor! Consider TOP (still assoc with mortality but lower than continuation)
Haemodynamic significance of any lesion due to cardiovascular changes in pregnancy, labour
NYHA Functional class: I-II usually okay, III-IV consider TOP
Presence of cyanosis

27
Q

Pre-pregnancy counselling template

A

Pre-pregnancy counselling:

  • Observations BMI, BP, MSU dipstick, U+Es, Hb
  • Pre-pregnancy supplementation iodine + folic acid
  • Current medications + teratogenicity risk
  • Smear Hx, immunisations
  • Smoking cessation
  • Pre-pregnancy genetic counselling
  • Disease specific: e.g. echo, functional assessment, need for treatment prior to pregnancy, - Contraception: any reason to AVOID pregnancy e.g pulmonary HTN, dialysis, Marfan’s aortic root >40mm

Effect of disease on pregnancy

  • maternal
  • fetal

Effect of pregnancy on disease
- deterioration - short term or permanent

Antenatal care

  • MDT involvement
  • Serial monitoring (maternal and fetal)
  • delivery plan
28
Q

Skin changes in pregnancy

Underlying pathogenesis

A

Hyperaemia - vasodilation from lower total peripheral resistance
Striae - increased tension on skin (higher with multiples, obesity), breakdown of collagen and elastin
Pigmentation (melasma, linea nigra) - oestrogen stimulates melanocytes
PP hair loss = telogen effluvium - conversion from growth to resting phase
Palmar errythema - oestrogen
Spider naevia - oestrogen

29
Q

Pre-existing skin conditions and effect in pregnancy

A

Acne - may get better or worse
Eczema - often worse from higher Th2 immunity
Psoriasis - often better from higher Th2 immunity

30
Q

Fetal risks of warfarin
Percentage chance
Ways to reduce

A

Fetal warfarin syndrome - nasal hypoplasia, short proximal limbs, short phalanges, stipled epiphyses, scoliosis, cognitive impairment.
Miscarriage
ICH if given within 2weeks of birth

6%

Switch to LMWH from 6-12weeks and 2weeks prior to planned delivery
Switch to LMWH for entire pregnancy - must monitor antiXa levels (higher maternal VTE risk)
If anticoagulated and need delivery - prothrombinex, vitamin K, FFP

31
Q

TB in pregnancy

A

Treat active ASAP
Delay latent Rx - pregnancy does not exacerbate
Report
HIV test
ABx - multi agent due to resistance
Monitor - LFTs, vision
Birth - breastfeeding okay, contact trace, BCG vaccine to baby

32
Q

Dopplers - predictors for acidaemia and triggers for delivery

A

DV - moderate predictor of fetal acidaemia and morbidity. Strong marker of cardiac compromise
Use to time delivery in IUGR babies with abnormal UAPI <32weeks
Abnormal, late changes (reversed/absent a wave) <32weeks - deliver
Use of late changes TRUFFLE - no difference in survival without neurosensory impairment at 2 years, possible improvement at 2 years

UAPI - overall high predictor of fetal acidaemia, hypoxia (AREDF in particular)
Use of this in high risk pregnancies reduces morbidity and mortality by 29%, may reduce obstetric intervention
Abnormal <32weeks - use DV
Reversed EDF, even with normal DV - consider 30-32weeks
Absent EDF - consider 33-34weeks
Abnormal >34weeks - aim delivery by 37weeks

MCA - poor predictor of acidemia in preterm fetus, moderate predictor of fetal acidaemia at/near term
If IUGR, normal UAPI but abnormal MCA 55% risk EmCS for fetal distress
Abnormal - delivery by 37weeks (RCOG), 38weeks (NZMFM)

CPR - better prognostic accuracy than MCA, marker of intrapartum fetal compromise