ObGyn4 DM,HTN,PEC, other complications Flashcards
Chronic HTN (criteria)
- Dx’d prior to pregnancy, or
- Dx’d before 20wks
Mild PEC (criteria)
- 140/90
- 0.3g/24hr (1+/2+ dipstick)
- sxs absent (oliguria, LFTs, thrombocytopenia, HA, RUQ, vision, etc)
Severe PEC (criteria)
- 160/110
- 5g/24hr (3+/4+ dipstick)
- sxs present (oliguria, LFTs, thrombocytopenia, HA, RUQ, vision, etc)
PEC (time)
after 20 wks
PEC superimposed on chronic HTN (definition)
- chronic HTN w/o proteinuria w/ onset of proteinuria
- chronic HTN w/ proteinuria w/ onset of severe proteinuria, severe BP rise, thrombocytopenia, LFTs
Gestational HTN (criteria)
- HTN w/o proteinuria after 20wks
- If returns to nl, then “transient HTN”
PEC (path x2)
- Vasospasm (reduced perfusion)
- Capillary wall injury (leaky, coagulable)
Chronic HTN (monitoring)
- Monthly US for IUGR
- If IUGR (+), weekly NSTs/BPPs
Chronic HTN (tx)
- Methyldopa
- Labetalol
PEC/EC (tx)
- Mg first
- Then consider delivery (vaginal preferred; c/s for maternal/fetal distress); term is OK with mild PEC
RUQ pain (path)
Stretching of hepatic (Glisson’s) capsule
Reason for Mg administration
To prevent FUTURE seizures, not control current one
Mg side effects and antidote
- Depressed DTRs
- Respiratory depression
- Calcium gluconate
GDM (patho)
Insulin resistance d/t:
- Increased human placental lactogen (hPL)
- Increased insulinase
Class A1 vs A2 GDM
A1: managed by diet alone
A2: insulin
Class B DM
- onset >20yo WITH duration <10yrs
- no vascular complications
Class C DM
- onset 10-19 OR duration 10-19yrs
- no vascular complications
Class D DM
- onset < 10yo OR duration > 20yrs
- vascular complications present
Class F DM
Diabetic nephropathy
Class R DM
Proliferative retinopathy
Class T DM
Renal transplant
Class H DM
Arteriosclerotic heart disease
DM (antepartum complications)
- Polyhydramnios
- Increased risk for PEC
DM (intrapartum complications)
- Dysfunctional labor (overdistended uterus)
- Traumatic/operative/cesarean delivery (fetal macrosomia)
DM (fetal/neonatal complications)
- Hypoglycemia, hypocalcemia, polycythemia (hyperbili)
- NTDs, sacral agenesis, cardiac anomalies
- Macrosomia (shoulder dystocia, brachial plexus injury), IUGR, respiratory distress
Euglycemic goals for GDM and DM
- FBS: < 90 mg/dl
- 1hr: < 140 mg/dl
- 2hr: < 120 mg/dl
Oral hypoglycemic agents (use?)
Contraindicated d/t fetal nephrotoxicity
GDM (initial screening: step 1)
1hr, 50mg OGTT @ 24-28wks
-NL: <140 mg/dl
GDM (confirmatory test: step 2)
3hr, 100mg OGTT (2/3 for dx):
- FBS >95mg/dl
- 1hr: >180mg/dl
- 2hr: >155mg/dl
- 3hr: >140mg/dl
GDM/DM (monitoring)
-weekly NSTs and AFI @ 32wks