Obesity - Week 3 Flashcards

1
Q

How many people in world are obese?

A

2.1 billion

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2
Q

How many obesity deaths?

A

300k/yr in us

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3
Q

What is the cost of obesity?

A

147 millin

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4
Q

Who has the highest rates of obesity?

A

non hispanic blacks

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5
Q

Who has the lowest rates of obesity?

A

non-hispanic asain

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6
Q

How much does obesity increase risk of death from all causes?

A

50-100%

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7
Q

How much can obesity decrease life span?

A

2-13 yrs

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8
Q

What shape confers the highest risk?

A

apple shape

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9
Q

What does adipose tissue secrete?

A
inflammatory mediators
IL
TNF
resistin
adiponectin
leptin
"adipocytokines"
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10
Q

What is apple shape?

A

android

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11
Q

What is pear shape?

A

gynoid

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12
Q

What waist hip ratio give greatest risk?

A

> .85 women, >.9 men

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13
Q

What specific group has the highest rate of being overwt or obese?

A

AA women

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14
Q

What are medications associated with obesity?

A
atherosclerosis
DM type II
osteoarthritis
gout
obstructive sleep apnea
POS
incontinence
cancer
depression
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15
Q

How does atherosclerosis relate to obesity?

A

low fruit and veggies

red meat raises risk

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16
Q

What does higher fiber diet =

A

reduced risk of atherosclerosis and obesity

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17
Q

How much does red meat daily increase morality?

A

15-20%

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18
Q

What amount of DM is linked to obesity?

A

80%

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19
Q

What is the highest risk BMI for DM?

A

> 35

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20
Q

What waist circumference has higher risk of DM?

A

> 40 men and >35 women

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21
Q

What occurs with DM and obesity?

A
impaired ability of insulin to regulate gluconeogenesis
increase glucose
increase LDL
reduce HDL
Hyperinsulinemia
INFLAMMATION
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22
Q

How does obesity relate to osteoarthritis?

A

increase load –> articular cartilage
loss of skeletal muscles –> articular shock absorption
adipocytokines w/ synovial fluid

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23
Q

Is osteoarthritis just wear and tear?

A

no, also inflammatory

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24
Q

What is the most common type of osteoarthritis in obesity?

A

knee

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25
Q

What BMI range accounted for nearly half of 730 cases of gout over 12 yrs?

A

> 25

26
Q

What happens in insulin resistance?

A

increase urate and decrease excretion

27
Q

How can you improve gout?

A

wt loss

28
Q

What is the strongest risk factor for OSA?

A

obesity

29
Q

What are the two things in OSA?

A

neck and waist ratios

30
Q

10% wt increase =

A

6x OSA increase

31
Q

What happens in PCOS?

A

hirsutism, amenorrhea, infertility, polycystic ovaries

32
Q

What % of premenopausal women have PCOS?

A

6-10%

33
Q

What is a big issue for PCOS?

A

infertility

34
Q

Do all PCOS pt have obesity?

A

no

35
Q

What does a 5 point increase in BMI result in?

A

20-70% increase in incontinence

36
Q

What is the common type of incontinence?

A

stress incontinence

37
Q

What is incontinence due to?

A

intra admonial pressure and intravesicle pressure, increase urethral mobility

38
Q

acne inversa results in formation of follicular occlusion, probably induced by occlusion/shear stress and increased insulin like growth factors in high glycemic diets, can be difficult to cure, sometimes surgery is needed

A

Hidradenitis suppuritiva

39
Q

What causes interigo?

A

yeast

40
Q

What types of cancers does obesity make it hard to detect?

A

pelvic and breast

41
Q

How is cancer related to obesity?

A

Increased estrogen produced by adipose tissue
Insulin like growth factor increases = tumor development
Adipokines, such as leptin, promotes cell proliferation
Inflammation

42
Q

Cancer of endometrial lining of uterus?

A

endometrial cancer

43
Q

What % of endometrial cancer attributed to wt?

A

40%

44
Q

What are the risk factors for endometrial cancer?

A

elevated levels of androgens, estrogen, hyperinsulinema related to obesity and increased adipose tissue

45
Q

What is the relationship with breast cancer and premenopausal obese women?

A

less cases

46
Q

When does wt gain increase risk of breast cancer?

A

40

47
Q

How does wt loss after 40 yo affect breast cancer risk?

A

NO AFFECT

48
Q

What diet is linked to colon cancer?

A

sugar and low fiber

49
Q

High refined sugar diet → hyperinsulinemia and insulin resistance increased levels of free insulin-like growth factor 1 (IGF-1)→ results in decrease in apoptosis and increase in cellular growth → cancer development

A

Yeah

50
Q

What directly stimulates colon cancer?

A

insulin

51
Q

Who gets colon cancer more?

A

obese men and premenopausal women

52
Q

What cause RCC with obesity?

A

hypoxia + hormonal changes + inflammatory changes

53
Q

What cancers are associated with increase meat intake?

A

prostate, colorectal, pancreatic, esophageal cancer

54
Q

What is the USPST recommendation for adults who are overwt or obese and have CVD risk factors for treatment recommendations?

A

B

55
Q

USPST recommendation for General adult population without a known diagnosis of hypertension, diabetes, hyperlipidemia, or cardiovascular disease for diet and exercise

A

C

56
Q

What is the diet and exercise recommendation from USPST for ALL adults?

A

B, screen all for obesity BMI>30

57
Q

What is the recommendation for diet and exercise USPST in children 6-18 yo?

A

B, >6 yo for obesity

58
Q

What is the USPST recommendation for pharmacotherapy inteventions in adults?

A

IP

59
Q

What are the exercise goals of health people 2020?

A

Reduce the number of adults who do not engage in leisure-time physical activity
Increase number of adolescents and adults who meet federal physical activity guidelines
Increase physical education programs in public schools
Increase regularly scheduled recess in elementary school
Decrease computer/TV/video game screen time to

60
Q

What is the american college of sports medicine recommendation?

A

150 minutes of exercise per week can be broken into 3-5 days
Incorporate resistance training into regimen
Flexibility training 2-3 days per week
Neuromotor exercises 2-3 days per week that focus on balance or agility, such as tai chi or yoga