obesity endo

Question 1

anorexigenic peptides

Answer 1

CART (cocaine and amphetamine related transcript)

alpha MSH

Question 2

orexigenic peptides

Answer 2

agrp (agouti related peptide)

npy (neuropeptide y)

Question 3

affect of leptin on npy

Answer 3

decrease (dec feeding)

Question 4

affect of leptin on agrp

Answer 4

decrease (dec feeding) and lift inhibition of MC4R (dec feeding)

Question 5

affect of leptin on cart

Answer 5

inc - dec feeding

Question 6

affect of leptin on alpha msh

Answer 6

inc - dec feeding

Question 7

cb1 inverse agonist

Answer 7

acomplia (rimonabant) - suicide risk

Question 8

SSRI inducing satiety

Answer 8

reductil - inc cvs risk

side effects: dry mouth, insomnia, constipation

Question 9

pancreatic lipase inhibitor

Answer 9

alli/orlistat, xenical

side effects: diarrhoea

Question 10

Satiety inducing peptides (3) produced by L cells in small intestine

Answer 10

cck - acts on NTS
PPY - post prandial nasal spray?
GLP1 - destroyed by dpp4 - exenedin 4 is resistant

Question 11

Hunger inducing peptides (2) produced by x/a cells in stomach

Answer 11

Ghrelin - acts on arcuate nucleus and vm hypothalamus,
inc in Prader Willi Syndrome

Orexins A and B - lateral hypothalamus, narcolepsy

Question 12

roux en y gastric bypass effect

Answer 12

reduce ghrelin, inc glp1 and ppy

Question 13

sleeve gastrectomy effect

Answer 13

improve glycaemic control and weight loss