Obesity (Brand/Generic)

Question 1

Phentermine

Answer 1

Adipex-P ®, Ionamin ®

NA/DA agent
Approved for short-term use (12 wks)
4 kg loss @ 6 months
CI: moderate-severe HTN, unstable CV function, substance abuse, glaucoma

Question 2

Diethylpropion

Answer 2

Tenuate ®

NA/DA agent
Approved for short-term use (12 wks)
4 kg loss @ 6 months
CI: moderate-severe HTN, unstable CV function, substance abuse, glaucoma

Question 3

Phendimetrazine

Answer 3

Bontril ®

NA/DA agent
Approved for short-term use (12 wks)
4 kg loss @ 6 months
CI: moderate-severe HTN, unstable CV function, substance abuse, glaucoma

Question 4

Lorcaserin

Answer 4

Belviq ®

Selective 5-HT 2C receptor agonist
4.8 kg loss in 2 yrs
CI: pregnancy and in combination with other SSRI’s

Question 5

Orlistat

Answer 5

Alli ®, Xenical ®

Lipase inhibitor
Take 3x/day 1 hr prior to meals
3kg loss (XENDOS study 5.8kg loss in 4 yrs)
CI: Pregnancy, malabsorption (Crohns, IBS)
Interacts with warfarin

Question 6

Phentermine + Topiramate

Answer 6

Qsymia ®

NA/DA agent + anti-epileptic
12kg loss, 6.7-8.9%
CI: récent hx of MI or stroke, pregnancy, hyperthyroidism, glaucoma, depression

Question 7

Which of the following are CI in pregnancy?

A. Lorcaserin
B. Qsymia ®
C. Xenical ®
D. Belviq ®
E. All of the above

Answer 7

(E) All of the above

Lorcaserin (Belviq ®)

Question 8

Which obesity med is taken 3x/day 1 hr prior to meals?

Answer 8

Orlistat (Alli ®, Xenical ®)

Question 9

Which obesity med(s) is CI in patients with moderate-severe HTN?

Answer 9

All the NA/DA agents:

1. Phentermine (Adipex-P ®)
2. Diethylpropion (Tenuate ®)
3. Phendimetrazine (Bontril ®)
4. Phentermine + Topiramate (Qsymia ®)

Question 10

Which of the following meds with an FDA approved indication for obesity carries a risk of serotonin syndrome?

A. Fluoxetine
B. Alli ®
C. Belviq ®
D. Bontril ®
E. Both A & C

Answer 10

(C) Belviq ® (Lorcaserin) is an FDA approved selective 5-HT agonist to treat obesity

A - Fluoxetine is an SSRI that does have a risk of serotonin syndrome, but is not FDA approved to treatment obesity (used in depression)

B - Alli ® (Orlistat) is a lipase inhibitor
D - Bontril ® (Phendimetrazine) is a NA/DA agent approved for short-term (12wk) Tx of obesity

Question 11

Which obesity med yields the largest decrease in weight?

Answer 11

Phentermine + Topiramate (Qsymia ®) - 12kg, 6.7-8.9%