BPH (Brand/Generic)

Question 1

Doxazosin

Answer 1

Cardura ®

Class: Non-selective alpha-blocker

Common SE: dizziness, fatigue, orthostatic hypotension

DI: Additive ↓ BP effect with anti-HTN

Question 2

Terazosin

Answer 2

Hytrin ®

Class: Non-selective alpha-blocker

Common SE: dizziness, weakness, orthostatic hypotension, somnolence (drowsy), nasal congestion

DI: Additive ↓ BP effect with anti-HTN

Question 3

Alfuzosin

Answer 3

Uroxatral ®

Class: Uroselective alpha-blocker

Common SE: dizziness, fatigue, HA, URI

DI: CI with potent CYP3A4 inhibitors

Question 4

Silodosin

Answer 4

Rapaflo ®

Class: Uroselective alpha-blocker

Common SE: retrograde ejaculation, dizziness, orthostatic hypotension, diarrhea, nasal congestion

DI: CI with potent CYP3A4 inhibitors. Not recommended with p-gp inhibitors (cyclosporine)

Question 5

Tamsulosin

Answer 5

Flomax ®

Class: Uroselective alpha-blocker

Common SE: dizziness, orthostatic hypotension, HA, rhinitis, abnormal ejaculation

DI: CI with potent CYP3A4 inhibitors. Caution with CYP2D6 inhibitors (cimetidine)

Question 6

Dutasteride

Answer 6

Avodart ®

Class: 5-alpha Reductase Inhibitor

Common SE: ED, ↓ libido, ejaculation disorders, gynecomastia

DI: Strong CYP3A4 inhibitors will ↑ concentrations

Question 7

Finasteride

Answer 7

Proscar ®

Class: 5-alpha Reductase Inhibitor

Common SE: ED, ↓ libido, ejaculation disorders, gynecomastia

DI: None!!!

Question 8

Tadalafil

Answer 8

Cialis ®

Class: PDE-5 Inhibitor

Administered po once daily for BPH indication