Obesity and T2D Flashcards
What type of diabetes is most common?
Type 2
What causes T1D?
Pancreas makes insufficient insulin
3 stages in the development on T2D
resistance to insulin
pancreas works overtime to make more insulin= hyperinsulinemia
this eventually results in beta cell function impairment
2 factors associated with T2D
Obesity
Abdominal adiposity
What does central obesity cause?
And what does this and _ result in
Increase in free fatty acids+ insulin resistance
increased lipase levels
What does an increase in lipase levels cause?
Increased triglycerides and LDLs
Fall in HDLs
Which 3 metabolic defects cause hyperglycaemia
- Insulin resistance
- Impaired insulin secretion
- Increased glucose production
What are the characteristics of adipose-KO mice?
Hyperphagia
Hyperglycaemia
Insulin resistance
T2D
What does adipose tissue secrete? And what is its primary target?
Leptin
The brain
Whats the Tbg transgenic line?
Reports the beta cells of the exocrine pancreas
What is EDU labelling ?
A way of analysing proliferation
EDU is an analog of thymidine- incorporated into the DNA during DNA synthesis
Which two developmental processes in the fish happen at the same time?
Pancreas grows its popultation of insulin producing beta cells
microbial population of the gut becomes established
What happens to zebrafish larvae grown in a microbe free envrionment ?
Number of insulin producing beta cells doesn’t increase- from the number before hatching
What protein does the microbes produce?
BefA
What confirmed that the pancreas has a regenerative capacity? And why is this significant information
If you ablate beta cells in adult mice, there is a recovery of the number of beta cells
T2D- low number of beta cells/ damaged cells- we can try and stimulate regeneration and use it therapeutically
