Obesity and Diabetes

Question 1

lethargy, syncope and diplopia are symptoms of what?

Answer 1

hypoglycemia

Question 2

Auto-immune mediated destruction of pancreatic beta cells results in type 1 diabetes, which is associated with HLA___ and HLA ____

Answer 2

HLA DR3 and HLA DR4

Question 3

Variable B cell numbers in the islets with amyloid deposits in patients >40 are usually seen in ____

Answer 3

Type 2 DBM

Question 4

polyuria, polydipsia, polyphageia, weightlosss are classically seen in ____

Answer 4

Type 1 diabetics, occasionally in type 2

Question 5

glutamic acid decarboxilase auto-antibodies are responsible for what?

Answer 5

death of pancreatic beta cells in type 1 diabetics

Question 6

D
K
A
D

Answer 6

Delerium/Psychosis
Kussmaul respirations (rapid/deep breathing)
Abdominal pain/nausea/vomiting
Dehydration

Question 7

What contributes to demyelination and sensory deficits in chronic diabetes melitus?

Answer 7

sorbitol deposition (aldose redcutase makes sorbitol from , sorbitol dehydrogenase eliminates it)

Sorbitol is an intermediate in glucose conversion to frucotose, which forms advanced glycosylation end products