Gereral pharm questions

Question 1

What does this describe?

Polyuria
polydipsia
nausea
fatigue
dehydration
Kassmaul breathing
fruity breath

Answer 1

Diabetic ketoacidosis

treat with IV insulin, fluid/electrolyte replacement

fruity breath due to acetone

Question 2

T/F Glyburide has an active metabolite that requires decreased done with renal dysfunction

Answer 2

true

Question 3

What sulfonylurea should be dose decreased with hepatic function?

Answer 3

Glipizide

Question 4

What drug could you give just before meals as an adjunctive therapy in Type II diabetes?

Answer 4

Repaglinide - blocks K+ channels in pancreatic beta cells

Question 5

Where is Type 1 dioidinase primariliy expressed? What is their function?

Answer 5

Liver and kidney

converts T4 (prohormone) to T3

~24 percent off total circulating T3 due to Type 1 diodinase

Question 6

Where is Type 2 dioidinase primariliy expressed? Which type is responsible for more circulating T3?

Answer 6

central nervous
system, pituitary gland, thyroid, heart, brown
adipose tissue, and skeletal muscle.

60% of total T3