Obesity 2

Question 1

What is insulin resistance?

Answer 1

slow glucose disposal in a glucose tolerance test that measures the rate of glucose clearance at defined incline level

High fasting insulin level

Question 2

What is reduced in obese ppl that contributes to the accumulation of free fatty acids and insulin resistance?

Answer 2

adiponectin

Question 3

What does B-Oxidation do?

Answer 3

decreases Lipolysis

Question 4

What stimulates B-Oxidation?

Answer 4

adiponectin and leptin

Adiponectin low in obese ppl so no B-oxidation–so increased lipolysis–increased NEFA

Question 5

What does AMPK do?

Answer 5

Promotes phosphorylation of ACC which is inactive form—this prevents conversion of acetyl coa—->Malonyl coa (inhibits CPT1, which allows FA to enter mito for oxidation)

Basically blocks the blocker for B-oxidation and allows B-oxidation to occur

Question 6

What does AMPK do?

Answer 6

Promotes phosphorylation of ACC which is inactive form—this prevents conversion of acetyl coa—->Malonyl coa (inhibits CPT1, which allows FA to enter mito for oxidation)

Basically blocks the blocker for B-oxidation and allows B-oxidation to occur

Question 7

What does exercise promote?

Answer 7

increases B-oxidation
Decreases fat accumulation
Increases AMPK activity

Question 8

What is the target for Fibrates and what is there affect?

Answer 8

PPARa ligands– promotes up regulation of enzymes involved in B-Oxidation

Lowers TG and LDL-C
Raises HDL-C

Question 9

What is the target for Thiazolidinediones and what it there affect?

Answer 9

PPARg ligands– promotes insulin action and FA uptake–downregulates lipolysis

Decrease in circulating NEFA–which incases insulin sensitivity