Obesity

Question 1

How does orlistat work

Answer 1

Derivative of an endogenous lipstatin produced by Streptomyces toxytricini.

Gastric and pancreatic lipase inhibitor

Reduces dietary fat absorption by around 30%.

Question 2

Leptin deficiency causes

Answer 2

Infertility.
Stunted linear growth.
Decreased body temperature.
Decreased energy expenditure.
Decreased immune function.

Question 3

What is leptin produced by

Answer 3

adipose cells

Question 4

What does leptin do

Answer 4

Helps regulate synthesis of thyroid hormones
Decreases glucose-stimulated insulin secretion
Increases heart rate
Regulates bone mass, menstrual cycle, appetite
Activates immune cells
Increases BP

Question 5

What does GLP-1 do

Answer 5

Stimulates insulin secretion and inhibits glucagon secretion
Delays gastric emptying and increases gastric volumes - reducing appetite
Lowers plasma lipids

Question 6

Liraglutide/Saxenda

Answer 6

Long-acting glucagon-like peptide-1 receptor agonist from Novo Nordisk.
Daily injection.
Double the dose used for T2DM.
4-5% weight loss

Question 7

Semaglutide

Answer 7

Long-acting glucagon-like peptide-1 (GLP-1) receptor agonist.

Question 8

Tirzepatide

Answer 8

Long-acting glucagon-like peptide-1 (GLP-1) receptor and glucose-dependent insulinotropic Polypeptide (GIP) receptor co-agonist.