Genes Flashcards
1
Q
BRCA-2
A
breast cancer
2
Q
CA19-9
A
pancreatic cancer tumour marker
3
Q
HLA-DR
A
Rheumatoid arthritis
4
Q
HLA-B27
A
ankylosing spondylitis
5
Q
anaplastic lymphoma kinase (ALK) tyrosine kinase - young patients, non-smokers
e-ROS oncogene 1 (ROS1) receptor tyrosine kinase - younger patients, non-smokers
BRAF (downstream cell-cycle signalling mediator) - esp in smokers
A
small cell lung cancer
6
Q
PDL-1
A
tumour cell marker for lung cancer that determines type of therapy. First line for metastatic NSCLC with no mutation and PDL >50% is immunotherapy using drugs such as
pembrolizumab, atezolizumab, nivolumab.
