Obesity Flashcards
Weight loss in obesity leads to reduced satiety by a number of mechanisms ?
Reduced leptin (satiety hormones)
Weight loss in obesity leads to reduced satiety by a number of mechanisms ?
Increased hunger hormones (ghrelin)
Weight loss in obesity leads to reduced satiety by a number of mechanisms ?
Increased neural activity associated with processing food- related stimuli
(Neurpeptide Y)
Weight loss in obesity leads to reduced satiety by a number of mechanisms ?
Decreased neural activity associated with retaining responses to food (cholecystokinin)
Leptin tell the brain?
You are full
Hungry hormone
Ghrelin
Ghrelin tells us we are…
Hungry
Where is leptin secreted from?
Adipose tissue
Ghrelin is located in the?
G cell / stomach
Where is insulin, amylin secreted from?
B cells/ pancreas
Where in the brain is the appetite centre?
Hypothalamus
Why is GLP-1 relevant to appetite and weight maintenance?
Has actions on the gastrointestinal tract, It regulates appetite directly. It delays gastric emptying & gut motility
Why is GLP-1 relevant to appetite and weight maintenance?
Regulates appetite & actions on the gastrointestinal tract
What are the appetite suppressing neurons?
Gut peptides: GLP-1, PYY, CCK
What does EOSS stand for?
Edmonton obesity staging system
What Tool do you use to assess obesity?
EOSS
Edmonton obesity staging system
How many stages has the eoss tool?
0, 1, 2, 3, 4
5
What biochemistry markers should we check in patients with obesity?
D, iron, B12, folate
What are the protein requirements for a person with obesity?
+1gm/kg/ IBW/day
Possible dietary factors to consider for therapeutic assessment ( hypertention)
Salt, alcohol
Possible dietary factors to consider for therapeutic assessment (NAFLD)
Alcohol, protein, salt, carb (quantity, quality), fluid restrictions
Possible dietary factors to consider for therapeutic assessment (sarcopenia)
Protein
Possible dietary factors to consider for therapeutic assessment (PCOS)
CHO (Q&Q), FAT type
Possible dietary factors to consider for therapeutic assessment (CKD)
Protein, potassium, phosphate, salt, fluid restrictions
Possible dietary factors to consider for therapeutic assessment (obstructive sleep apnoea)
Meal patterns, caffine
Possible dietary factors to consider for therapeutic assessment (GORD)
Alcohol, spice, caffeine, fat quantity/ type
Possible dietary factors to consider for therapeutic assessment (IBS)
Meal patterns, fibre type, probioics, caffeine influence
What are the ways to achieve or manage satiety/ appetite
Increase protein, fibre, water, food volume, reduce glycaemic index, non distracting eating, pace eating
When should liraglutite be discontinued?
D/c for patients who have not loss 5% r greater of initial body weight after 12 was on treatment at dose 3mg/ day
Semaglutide affects what receptor?
GLP-1
GLP-1 stands for ?
Glucagon like peptide 1
Semaglutide blinds to GLP-1 receptor and does what?
Increases insulin secretion, suppress glucagon secretion, slows gastric emptying *reduces appetite
Whay does orlistat do?
Reduces fat absorption by approx 30%.
It partially inhibits hydrolysis of triglycerides &reduces absorption of monoaclglycerides & free fatty acids
